中国寄生虫学与寄生虫病杂志 ›› 1983, Vol. 1 ›› Issue (2): 99-101.
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易有云,程眉荪,邹万忠
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摘要: 用Chang氏培养基繁殖福氏纳格勒阿米巴滋养体,经鼻腔接种3只小鼠,1鼠不接种作为对照。观察4周,其中2只接种鼠分别于第13、19天发病,1只接种鼠未发病。于第14天剖杀2只实验鼠和1只对照鼠,取脑作病理及病原学检查,发现接种鼠均有典型的病变,涂片及切片中均有大量吞噬红细胞的滋养体。对照鼠无何异常发现。本文从病理及病原学等结果证实本实验接种的小鼠可作为福氏纳格勒阿米巴原发性脑膜脑炎的动物模型。
关键词: 原发性阿米巴脑膜脑炎, 小鼠模型, 阿米巴滋养体, 动物模型, 病原学检查, 红细胞, 铁苏木素染色, 中性白细胞, 棘阿米巴, 鼻腔接种
Abstract: A strain of axenic Naegleria fowleri was proliferated massively in Chang's medium and was introduced 'intranasally into 3 mice which were closely observed for 2-3 weeks. On the 13th day mouse 1 developed primary amoebic meningoencephalitis (PAME) symptoms, but mouse 2 had no signs of PAME at all at that time. On the 19th day, mouse 3 developed the same symptoms as mouse 1. Mice 1,2 and 4 were killed and autopsied for pathological examination. Mouse 3 was fixed in toto to keep the spasmodic posture.According to the typical manifestation, pathological findings and etiological characteristics, these mice were proved to be suitable models of Naegleria fowleri PAME.
易有云,程眉荪,邹万忠. 福氏纳格勒阿米巴原发性脑膜脑炎小鼠模型的建立[J]. 中国寄生虫学与寄生虫病杂志, 1983, 1(2): 99-101.
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