三氯苯达唑治疗片形吸虫病耐药现状与研究进展

doi:10.12140/j.issn.1000-7423.2025.05.018

摘要/Abstract

摘要：

片形吸虫病是由肝片形吸虫和巨片形吸虫感染引起的一种人兽共患寄生虫病，该病不仅影响人类健康，还对以食草动物为主的其他哺乳动物造成严重危害。三氯苯达唑（TCBZ）是治疗片形吸虫病的首选药物，但卫生经济学数据监测提示TCBZ耐药威胁已对流行区动物健康带来挑战，并产生了巨大的经济损失；同时，临床上报道的可能与TCBZ耐药相关的治疗失败情况，为片形吸虫病的防治带来风险。本文重点阐述了TCBZ治疗片形吸虫病失败和/或耐药现状、TCBZ耐药风险因素、耐药机制、新药研发及新的治疗手段探索的进展，以期为片形吸虫病防治的进一步研究提供参考。

关键词: 片形吸虫病, 三氯苯达唑, 耐药, 研究进展

Abstract:

Fascioliasis, which caused by Fasciola hepatica and F. gigantica, is a zoonotic parasitic disease that not only affects human health but also poses a serious threat to other mammals, especially herbivores. Triclabendazole (TCBZ) is the first choice for fascioliasis treatment. However, economic data monitoring in health care indicates that the threat of TCBZ resistance has brought challenges to the health of animals in endemic areas and caused huge economic losses. At the same time, clinical reports have also documented treatment failures possibly related to TCBZ resistance, posing risks to the prevention and control of fascioliasis. This article focuses on the current situation of TCBZ treatment failure and/or resistance in fascioliasis, risk factors for TCBZ resistance, resistance mechanisms, progress in new drug development and exploration of new treatment methods, with the aim of providing references for further research on the prevention and control of fascioliasis.

Key words: Fascioliasis, Triclabendazole, Drug resistance, Research progress

中图分类号:

R532.29

陈冲, 朱爱红, 黄琴. 三氯苯达唑治疗片形吸虫病耐药现状与研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(5): 718-722.

CHEN Chong, ZHU Aihong, HUANG Qin. Current status and research progress of triclabendazole resistance in fascioliasis treatment[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2025, 43(5): 718-722.

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