The interplay between Toxoplasma gondii infection and autophagy in host cells

doi:10.12140/j.issn.1000-7423.2021.04.019

Abstract

Abstract:

Toxoplasma gondii is an important obligate intracellular pathogenic protozoan with worldwide distribution that may cause zoonotic toxoplasmosis, severely impacting the human health and the economy of animal husbandry. Studies have shown that the type I strain of T. gondii can escape from the killing effect of autophagy in host cells by changing the expression of autophagy-related proteins in the host, while the type Ⅱ and Ⅲ strains of T. gondii can be effectively cleared up or suppressed by the autophagy system of host cells. This review provides an update on the interplay between T. gondii infection and host cell autophagy system and the related molecular mechanisms.

Key words: Toxoplasma gondii, Infection, Host cell, Autophagy, Interplay

CLC Number:

R382.5

HOU Yong-heng, LV Fang-li. The interplay between Toxoplasma gondii infection and autophagy in host cells[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(4): 537-542.

Figures/Tables 1

References 46

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