寄生虫胞外囊泡蛋白质组学研究进展

doi:10.12140/j.issn.1000-7423.2021.04.017

摘要/Abstract

摘要：

胞外囊泡（EV）是一种由多种细胞分泌的内含蛋白质、核酸和脂质的磷脂双分子层囊泡,是参与细胞间相互作用的重要介质。寄生虫在入侵、生存和繁殖过程中利用EV向外界分泌蛋白质,调节宿主免疫反应,有利于自身寄生。本文对近年来寄生蠕虫、原虫EV蛋白质组学方面的研究进展进行综述,为描述寄生虫-宿主互作机制提供思路。

关键词: 寄生虫, 胞外囊泡, 蛋白质组学, 互作机制

Abstract:

Extracellular vesicles are lipid-bilayer vesicles containing proteins, nucleic acids and lipids, secreted by a variety of cells, and are important mediators involving in intercellular interactions. Parasites use extracellular vesicles to secrete proteins during invasion, survival and reproduction, thereby regulating the host immune response to benefit parasitism. This review summarizes the recent research progress on extracellular vesicle proteomics of parasitic helminths and protozoan, in order to provide clues for characterizing the mechanisms of host-parasite interplay.

Key words: Parasite, Extracellular vesicles, Proteomics, Interaction mechanism

中图分类号:

徐枫雁, 杨勇, 高欣, 刘晓雷, 王洋, 刘明远, 张媛媛, 白雪. 寄生虫胞外囊泡蛋白质组学研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(4): 526-532.

XU Feng-yan, YANG Yong, GAO Xin, LIU Xiao-lei, WANG Yang, LIU Ming-yuan, ZHANG Yuan-yuan, BAI Xue. Advances in research on parasite proteomics of extracellular vesicles[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2021, 39(4): 526-532.

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