中国寄生虫学与寄生虫病杂志 ›› 2007, Vol. 25 ›› Issue (2): 15-149.

• 现场研究 • 上一篇    下一篇

移民新建镇人群血吸虫抗体水平变化的观察

闻礼永1;陆绍红1;陈军虎1;张剑锋1;俞丽玲1;丁建祖1;严晓岚1;沈丽英1;郑伟2;高璐璐2;汪天平3;张世清3;陈更新4;叶昀5;周晓农6;郑江6

  

  1. 1 浙江省医学科学院寄生虫病研究所,世界卫生组织蠕虫病研究合作中心, 杭州 310013; 2 浙江省卫生厅疾病控制处,杭州 310006; 3 安徽省血吸虫病防治研究所,芜湖 241000; 4 安徽省贵池区血防站, 贵池 247100; 5 安徽省东至县血防站, 东至 247200; 6 中国疾病预防控制中心寄生虫病预防控制所, 世界卫生组织疟疾、血吸虫病和丝虫病合作中心, 上海 200025
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-04-30 发布日期:2007-04-30
  • 通讯作者: 闻礼永

Observation on the Change of Anti-S.japonicum Antibody Level inPopulation Migrated from Outside Embankment to New Town

WEN Li-yong1;LU Shao-hong1;CHEN Jun-hu1;ZHANG Jian-feng1;YU Li-ling1;DING Jian-zu1;YAN Xiao-lan1;SHEN Li-ying1;ZHENG Wei2;GAO Lu-lu2;WANG Tian-ping3;ZHANG Shi-qing3;CHEN Geng-xin4;YE Yun5;ZHOU Xiao-nong6;ZHENG Jiang6   

  1. 1 Institute of Parasitic Diseases, Zhejiang Academy of Medical Sciences, WHO Collaborating Center for Research on Helminthiasis, Hangzhou 310013, China; 2 Department of Disease Control, Health Bureau of Zhejiang Province, Hangzhou 310006, China; 3 Anhui Institute of Parasitic Diseases, Wuhu 241000, China; 4 Guichi District Station of Schistosomiasis Control, Guichi 247100, China; 5 Dongzhi County Station of Schistosomiasis Control, Dongzhi 247200, China; 6 Institute of Parasitic Diseases, National Center for Disease Prevention and Control, Shanghai 200025, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-30 Published:2007-04-30
  • Contact: WEN Li-yong1

摘要: 目的 通过血清学方法观察移民新建镇人群血吸虫抗体水平的变化。 方法 2002-2005年选择长江安徽段血吸虫病流行区退人又退耕的双退点、退人不退耕的单退点和未退人退耕的对照点各1个为试点,采用斑点金免疫渗滤法(DIGFA)与ELISA法纵向平行检测各试点人群血吸虫抗体水平。 结果 双退点DIGFA、ELISA测得的人群血吸虫抗体阳性率分别从2002年的6.63%、7.26%下降到2005年的3.52%和3.71%,差异均有统计学意义(χ2=5.2625,P<0.05;χ2=6.3296,P<0.05);单退点和对照点人群的血吸虫抗体阳性率无显著变化。ELISA纵向检测3个试点人群血清血吸虫抗体的吸光度(A450值)水平,经单因素方差分析,单退点2005年A450均值为0.147,较2003年的0.182有显著下降(P<0.01)。双退点、对照点人群的血吸虫抗体均值无显著变化。 结论 移民新建镇人群血吸虫抗体阳性率及抗体水平呈不同程度的下降。

关键词: 移民, 日本血吸虫, 抗体

Abstract: Objective To detect the change of the anti-S.japonicum antibody level after people migrated from outside embankment to newly established town. Methods Three pilot spots were established for the investigation: one spot that both inhabitancy and cultivation disused (A), one spot that only inhabitancy disused but farming continued (B) and the third one served as control (C). DIGFA and ELISA were used to detect the antibody level in the populations from 2002 to 2005. Results The positive rate of anti-S. japonicum antibody declined significantly from 6.63% to 3.52% by DIGFA and from 7.26% to 3.71% by ELISA at spot A (χ2=5.2625, P<0.05; χ2=6.3296, P<0.05, respectively). There was no significant difference on the positive rate of antibody in spots B and C. The average A450 value of ELISA in the three spots was statistically analyzed by One-Way ANOVA. It was only in spot B that the average A450 value declined from 0.182 in 2003 to 0.147 in 2005 (P<0.01). Conclusion The anti-S.japonicum antibody level in human population has decreased at certain degree after they migrated from outside embankment to new town.

Key words: Migration, Schistosoma japonicum, Antibody