弓形虫类锥体结构、功能及调控机制的研究进展

doi:10.12140/j.issn.1000-7423.2021.06.016

中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (6): 832-835.doi: 10.12140/j.issn.1000-7423.2021.06.016

弓形虫类锥体结构、功能及调控机制的研究进展

张小涵(), 冯颖, 陈冉, 桑晓宇, 杨娜^*()

沈阳农业大学畜牧兽医学院,沈阳 110866

收稿日期:2021-04-28 修回日期:2021-07-31 出版日期:2021-12-30 发布日期:2021-12-05
通讯作者: 杨娜
作者简介:张小涵（1996-）,女,硕士研究生,主要从事兽医寄生虫学研究。E-mail： 437415205@qq.com
基金资助:
国家自然科学基金面上项目(31672546);国家自然科学基金面上项目(32072891)

Advances in research of structure, function and regulatory mechanism of Toxoplasma gondii conoid

ZHANG Xiao-han(), FENG Ying, CHEN Ran, SANG Xiao-yu, YANG Na^*()

College of Animal Husbandry and Veterinary Medicine, Shengyang Agricultural University, Shengyang 110866, China

Received:2021-04-28 Revised:2021-07-31 Online:2021-12-30 Published:2021-12-05
Contact: YANG Na
Supported by:
General Project of National Natural Science Foundation of China(31672546);General Project of National Natural Science Foundation of China(32072891)

摘要/Abstract

摘要：

顶复合体是顶复门原虫特有的结构,由分泌型细胞器和细胞骨架元素件构成,其显著特征是具有一个由微管蛋白纤维组成的类锥体。弓形虫由于具备相对完整的类锥体,为剖析类锥体结构、组成和功能提供了一个成功模型。类锥体的稳定性和相关活动与弓形虫滑行运动、微线体蛋白分泌等生理过程密切相关,对弓形虫入侵宿主细胞至关重要。本文针对类锥体的结构稳定性、相关的蛋白功能以及调控机制展开综述。

关键词: 弓形虫, 类锥体, 滑行运动, 入侵, 钙调控

Abstract:

The apical complex is the typical structure of phylum Apicomplexa which consists secretory organelles and cytoskeletal elements, of which a marked feature is the conoid formed by tubulin fibers. Toxoplasma gondii has a relatively intact conoid, thus, it provides a successful model for analyzing the structure, composition and function of conoid. The stability and relevant activities of conoid are closely related to gliding motility and microneme secretion in of Toxoplasma, and are critical for host cell invasion. In this paper, the structure stability, protein function and regulatory mechanism of conoid are reviewed.

Key words: Toxoplasma gondii, Conoid, Gliding motility, Invasion, Calcium regulation

中图分类号:

R382.5

张小涵, 冯颖, 陈冉, 桑晓宇, 杨娜. 弓形虫类锥体结构、功能及调控机制的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(6): 832-835.

ZHANG Xiao-han, FENG Ying, CHEN Ran, SANG Xiao-yu, YANG Na. Advances in research of structure, function and regulatory mechanism of Toxoplasma gondii conoid[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2021, 39(6): 832-835.

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弓形虫类锥体结构、功能及调控机制的研究进展

Advances in research of structure, function and regulatory mechanism of Toxoplasma gondii conoid

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