自然杀伤细胞及其受体与血吸虫病肝纤维化

摘要/Abstract

摘要：

日本血吸虫病是一种广泛流行的人兽共患寄生虫病。血吸虫感染后虫卵可沉积于宿主的肝脏,引起肝纤维化,严重者发展成肝硬化,严重影响患者的生活质量并成为重要的公共卫生问题。自然杀伤（NK）细胞是重要的天然免疫细胞,该细胞无需预先致敏即可对靶标产生即时反应。肝星状细胞（HSCs）是形成血吸虫病肝纤维化的肌成纤维细胞的主要来源。近年来研究发现,NK细胞可通过杀伤HSC来缓解肝纤维化,肝纤维化的发展与NK细胞活化状态密切相关。而NK细胞的功能状态取决于它表面抑制型或活化型受体的表达。本文就NK细胞及其受体的研究进展进行综述,对NK细胞抗血吸虫病肝纤维化研究进行展望。

关键词: 血吸虫病, 自然杀伤细胞, 表面受体, 肝纤维化, 肝星状细胞

Abstract:

Schistosomiasis japonica is a widespread zoonotic parasitic disease. The parasite eggs can deposit in the host liver after infection, causing hepatic fibrosis, which further progresses into cirrhosis. Schistosomiasis severely impairs the life quality of patients and has become a major public health problem. Natural killer (NK) cells are important innate immune cells, which can respond to the target without prior sensitization. Hepatic stellate cells (HSCs) are the major source of myofibroblasts that cause liver fibrosis in schistosomiasis. Recent studies showed that the NK cells can alleviate hepatic fibrosis by killing HSCs. The development of hepatic fibrosis is closely related to the status of NK cell activation, while the latter depends on the expression of their inhibitory or activating surface receptors. In this paper, recent research advances on NK cells and their surface receptors are reviewed, which provides a perspective of studies on the roles of NK cells against schistosomiasis liver fibrosis.

Key words: Schistosomiasis, Natural killer cell, Receptor, Hepatic fibrosis, Hepatic stellate cell

中图分类号:

R532.21

王晓玲, 胡媛, 曹建平. 自然杀伤细胞及其受体与血吸虫病肝纤维化[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(5): 504-509.

Xiao-ling WANG, Yuan HU, Jian-ping CAO. Associations of natural killer cells and their receptors with liver fibrosis in schistosomiasis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2018, 36(5): 504-509.

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