Th17/Treg免疫失衡在血吸虫病肝纤维化中的作用

摘要/Abstract

摘要：

血吸虫病肝纤维化是宿主感染血吸虫后发生免疫反应所致的一种严重病理性损害。肝脏的免疫应答状态决定了肝纤维化的进程。近期研究发现,Th17和Treg细胞是CD4⁺T细胞的2个亚群。Th17细胞主要参与炎症反应;Treg细胞主要介导负向调控。Th17/Treg细胞的分化相互抑制、功能反向调节,在正常状况下两者保持平衡。Th17、Treg细胞及其免疫平衡在维持机体内环境的稳定、参与炎症反应、组织损伤、纤维化及多种疾病的发生发展方面发挥着重要的作用。本文就Th17/Treg细胞及其免疫失衡在血吸虫病肝纤维化中的作用进行综述。

关键词: 血吸虫病, 肝纤维化, 辅助性Th17细胞, 调节性Treg细胞, 免疫平衡

Abstract:

Liver fibrosis in schistosomiasis is a serious pathological consequence from immune reactions to schistosome infection. The progression of liver fibrosis depends on the state of immune response. Recent studies have found that Th17 and Treg cells are two subsets of CD4⁺T cells. The Th17 cells are mainly involved in inflammatory responses, while the Treg cells mainly mediate downregulation of the responses. Under normal conditions, the differentiations of the two subsets are inhibited by each other, and they function oppositely. The balance between Th17 and Treg cells, as well as the balance between them, play an important role in the maintenance of homeostasis and are involved in inflammatory responses, tissue trauma, fibrosis and development of many diseases. This paper reviews the role of Th17/Treg cells and their imbalance in liver fibrosis in schistosomiasis.

Key words: Schistosomiasis, Hepatic fibrosis, Helper T cell 17, Regulatory T cell, Immunological balance

中图分类号:

R532.21

周永华, 杨莹莹, 范小琳, 赛雪. Th17/Treg免疫失衡在血吸虫病肝纤维化中的作用[J]. 中国寄生虫学与寄生虫病杂志, 2017, 35(1): 89-93.

Yong-hua ZHOU, Ying-ying YANG, Xiao-lin FAN, Xue SAI. The role of Th17/Treg imbalance in liver fibrosis in schistosomiasis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2017, 35(1): 89-93.

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