中国寄生虫学与寄生虫病杂志 ›› 2013, Vol. 31 ›› Issue (6): 12-473-476.

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间日疟原虫裂殖子表面蛋白3α基因多态性的研究进展

徐超, 徐秀来, 黄炳成   

  1. 山东省医学科学院山东省寄生虫病防治研究所,济宁 272033
  • 出版日期:2013-12-30 发布日期:2014-02-28

Research Progress on Polymorphism in the Merozoite Surface Protein-3α Gene of Plasmodium Vivax

XU Chao,XU Xiu-lai,HUANG Bing-cheng   

  1. Shandong Academy of Medical Sciences,Shandong Institute of Parasitic Diseases, Jining 272033, China
  • Online:2013-12-30 Published:2014-02-28

摘要: 间日疟原虫裂殖子表面蛋白3α(Plasmodium vivax merozoite surface protein-3α, PvMSP-3α)是红内期间日疟原虫裂殖子形态的一种表面蛋白。PvMSP-3α基因在世界范围内具有高度基因多态性,是对间日疟原虫进行基因分型和流行病学研究较合适的分子标记物,为开发抗疟疫苗提供了重要候选抗原。本文就PvMSP-3α的分子结构、基因多态性和基因分型作一综述。

关键词: 间日疟原虫, 分子标记物, 裂殖子表面蛋白3&alpha, 多态性, 基因分型

Abstract: The merozoite surface protein-3α of Plasmodium vivax(PvMSP-3α) is a surface protein that is expressed during the asexual blood stages. With a high polymorphism,  PvMSP-3α gene has been used as a suitable epidemiology and genotype marker. Moreover, it might be an important malaria vaccine candidate. This paper summarizes the research progress on the molecular structure, gene polymorphism and genotypes of PvMSP-3α.

Key words:  , Plasmodium vivax;Molecular marker;Merozoite surface protein-3&alpha, ;Polymorphism;Genotyping