广东省华支睾吸虫病综合防治项目防治成效评价

doi:10.12140/j.issn.1000-7423.2025.06.008

中国寄生虫学与寄生虫病杂志 ›› 2025, Vol. 43 ›› Issue (6): 800-805.doi: 10.12140/j.issn.1000-7423.2025.06.008

广东省华支睾吸虫病综合防治项目防治成效评价

张官婷¹()(), 张贤昌¹, 张启明¹, 罗乐², 曾庆生³, 方悦怡¹, 廖宇煌¹, 毛强¹, 刘佳慧¹, 邓卓晖¹, 吴德¹, 陈经雕¹^,^*()()

¹ 广东省疾病预防控制中心，广东省新发突发传染病防治工作站，广东广州 511430
² 中山市疾病预防控制中心，广东中山 528403
³ 江门市新会区疾病预防控制中心，广东江门 529100

收稿日期:2025-10-09 修回日期:2025-11-21 出版日期:2025-12-30 发布日期:2025-12-29
通讯作者: *陈经雕（ORCID：0009-0005-3311-7891），男，硕士，主任技师，从事传染病防控研究。E-mail：1400137369@qq.com
作者简介:张官婷（ORCID：0009-0009-7720-585X），女，硕士，主管医师，从事寄生虫病防治研究。E-mail：zhanggt3@qq.com
基金资助:
广东省疾病预防控制中心人才支持项目(2024D351);广东省新发传染病应急检测技术研究与应用重点实验室（2023年度）(2023B1212010010)

Evaluation of the effectiveness of the integrated clonorchiasis control programme in Guangdong Province

ZHANG Guanting¹()(), ZHANG Xianchang¹, ZHANG Qiming¹, LUO Le², ZENG Qingsheng³, FANG Yueyi¹, LIAO Yuhuang¹, MAO Qiang¹, LIU Jiahui¹, DENG Zhuohui¹, WU De¹, CHEN Jingdiao¹^,^*()()

¹ Guangdong Provincial Center for Disease Control and Prevention, Guangdong Provincial Workstation for Emerging Infectious Disease Control and Prevention, Guangzhou 511430, Guangdong, China
² Zhongshan Municipal Center for Disease Control and Prevention, Zhongshan 528403, Guangdong, China
³ Xinhui District Center for Disease Control and Prevention, Jiangmen City 529100, Guangdong, China

Received:2025-10-09 Revised:2025-11-21 Online:2025-12-30 Published:2025-12-29
Contact: *E-mail：1400137369@qq.com
Supported by:
Talent Support Program of Guangdong Provincial Center for Disease Control and Prevention(2024D351);Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response(2023B1212010010)

摘要/Abstract

摘要：

目的评价广东省华支睾吸虫病高流行区（中山市和江门市新会区）实施的综合防治措施，为其他地区提供可复制、可推广的综合防控经验。方法 2019—2023年中山市和江门市新会区实施华支睾吸虫病综合防治措施。采用线上线下结合的方式开展健康教育；结合新农村建设进行环境改造，普及卫生厕所和安全用水；对阳性感染者派发阿苯达唑进行药物治疗；通过培训和实操提升专业能力进行防治队伍建设。2个项目点在综合防治措施干预后，分别选取东、西、南、北、中5个方位各1个乡（镇、街道）的1个行政村（社区），整群抽取3周岁以上居民200人开展华支睾吸虫病人群感染调查，并以项目开始前的最近一次人群感染调查结果作为基线数据进行对比。在2019年防治项目开始前和2023年终期评估时，分别从调查人群中随机抽取150人进行人群健康行为问卷调查。结果 2019—2023年，中山市和新会区开展华支睾吸虫防治健康教育的行政村分别为277个和224个，覆盖率均达100%。2023年中山市和新会区的人群防治知识知晓率分别达96.0%（261/272）和98.0%（245/250），分别比2019年项目开展前的60.0%（150/250）和70.0%（105/150）升高了60.0%和40.0%。环境改造方面，中山市新建卫生厕所89 850所，新增安全卫生用水户数89 850户；新会区新建卫生厕所17 094所，新增安全卫生用水户数16 968户，两地卫生厕所和安全用水覆盖率均达100%。中山市和新会区通过社区人群感染调查和医疗机构的规范门诊分别发现华支睾吸虫阳性感染者10 424人和22 427人，派发药物10 185人和16 821人，驱虫覆盖率达97.71%和75.00%。专业人员培训率显著提升，中山市从91.67%（66/72）上升至100%（103/103），新会区从52.94%（90/170）上升至98.05%（201/205）。经过5年防治，中山市和新会区的华支睾吸虫感染率分别从基线调查的37.28%（400/1 073）和34.18%（499/1 460）下降至终期评估调查的11.52%（131/1 137）和10.20%（102/1 000），差异有统计学意义（χ² = 625.24、188.35，均P < 0.05）。结论广东省中山市和江门市新会区通过实施包括健康教育、环境改造、药物治疗、防治队伍建设在内的综合防治措施，显著降低了人群华支睾吸虫感染率，提高了防治知识知晓率和环境卫生水平，可向其他地区进行推广。

关键词: 华支睾吸虫病, 综合防治, 广东省

Abstract:

Objective To investigate the effectiveness of the integrated clonorchiasis control programme in hyperendemic areas of Guangdong Province (Zhongshan City and Xinhui District of Jiangmen City), so as to provide reproducible and scalable integrated control experiences in other disease-affected regions. Methdos Integrated clonorchiasis control measures were implemented in Zhongshan City and Xinhui District of Jiangmen City during the period from 2019 to 2023, including online and offline health education, environmental improvements focusing on construction of sanitary toilets and provision of safe water in the text of new rural construction, albendazole given to Clonorchis sinensis-infected individuals, improvements of professional capabilities among disease control teams by means of training and hands-on practices. An administrative village (community) was selected from each township (street) in eastern, western, southern, northern and central parts according to geographical locations in two implementation areas after implementation of the integrated control measures. A total of 200 residents at ages of over 3 years were sampled using the cluster sampling method for detection of the prevalence of human clonorchiasis. And use the findings from the most recent population infection survey conducted prior to the project’s initiation as baseline data for comparison. In addition, a total of 150 individuals were randomly sampled from residents subjected to surveys of the prevalence of C. sinensis human infections in 2019 prior to the programme and 2023 at the final evaluation for questionnaire surveys of healthy human behaviors. Results There were 227 administrative villages received health education pertaining to clonorchiasis control knowledge in Zhongshan City, and 224 in Xinhui District, with a coverage rate of 100% in both areas from 2019 to 2023. The awareness of human clonorchiasis control knowledge was 96.0% (261/272) in Zhongshan City and 98.0% (245/250) in Xinhui District in 2023, which increased by 60.0% and 40.0% relative to 2019 before implementation of the programme [60.0% (150/250) and 70.0% (105/150)], respectively. In terms of environmental improvements, 89 850 new sanitary toilets were built and 89 850 households with access to safe water were provided in Zhongshan City, and 17 094 new sanitary toilets were built and 16 968 households with access to safe water were provided in Xinhui District, with 100% coverage rates of sanitary toilets and safe water supply in both areas. There were 10 424 and 22 427 C. sinensis-infected individuals identified through community-based surveys on human infections and standardized clonorchiasis clinics in medical institutions in Zhongshan City and Xinhui District, and 10 185 and 16 821 individuals given deworming chemicals, with deworming coverage rates of 97.71% and 75.00%, respectively. The proportion of professionals receiving training increased from 91.67% (66/72) to 100% (103/103) in Zhongshan City and from 52.94% (90/170) to 98.05% (201/205) in Xinhui District. The prevalence of C. sinensis infections reduced from 37.28% (400/1 073) at baseline to 11.52% (131/1 137) at the final evaluation in Zhongshan City (χ² = 625.24, P < 0.05) and from 34.18% (499/1 460) to 10.20% (102/1 000) in Xinhui District following implementation of 5-year integrated control programmes (χ² = 188.35, P < 0.05), respectively. Conclusion Through systematic interventions, Zhongshan City and Xinhui District in Guangdong Province significantly reduced the infection rate of C. sinensis, enhanced public awareness of prevention knowledge, and improved environmental sanitation, providing replicable and scalable experiences for comprehensive control in other regions.

Key words: Clonorchiasis, Integrated control, Guangdong Province

中图分类号:

R532.23

张官婷, 张贤昌, 张启明, 罗乐, 曾庆生, 方悦怡, 廖宇煌, 毛强, 刘佳慧, 邓卓晖, 吴德, 陈经雕. 广东省华支睾吸虫病综合防治项目防治成效评价[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(6): 800-805.

ZHANG Guanting, ZHANG Xianchang, ZHANG Qiming, LUO Le, ZENG Qingsheng, FANG Yueyi, LIAO Yuhuang, MAO Qiang, LIU Jiahui, DENG Zhuohui, WU De, CHEN Jingdiao. Evaluation of the effectiveness of the integrated clonorchiasis control programme in Guangdong Province[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2025, 43(6): 800-805.

图/表 1

参考文献 17

[1]	Lai DH, Hong XK, Su BX, et al. Current status of Clonorchis sinensis and clonorchiasis in China[J]. Trans R Soc Trop Med Hyg, 2016, 110(1): 21-27.
[2]	邓卓晖, 方悦怡. 广东省华支睾吸虫病流行态势与防控策略[J]. 中国血吸虫病防治杂志, 2016, 28(3): 229-233.
	Deng ZH, Fang YY. Epidemic situation and prevention and control strategy of clonorchiasis in Guangdong Province, China[J]. Chin J Schisto Control, 2016, 28(3): 229-233. (in Chinese)
[3]	许隆祺, 陈颖丹, 孙凤华, 等. 全国人体重要寄生虫病现状调查报告[J]. 中国寄生虫学与寄生虫病杂志, 2005, 23(增刊): 332-340.
	Xu LQ, Chen YD, Sun FH, et al. Report on the national survey of the current status of important human parasitic diseases in China[J]. Chin J Parasitol Parasit Dis, 2005, 23 (S1): 332-340. (in Chinese)
[4]	王曼, 罗乐, 李雷, 等. 中山市居民华支睾吸虫感染情况及影响因素分析[J]. 中华疾病控制杂志, 2018, 22(11): 1189-1191.
	Wang M, Luo L, Li L, et al. Analysis of the infection status and influencing factors of Clonorchis sinensis among residents in Zhongshan City[J]. Chin J Dis Control Prev, 2018, 22(11): 1189-1191. (in Chinese)
[5]	王可艺, 舒黄芳, 方悦怡, 等. 2016—2020年广东省华支睾吸虫病高流行地区人群感染监测分析[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(5): 629-634.
	Wang KY, Shu HF, Fang YY, et al. Surveillance and analysis of Clonorchis sinensis infection in populations in highly endemic areas of Guangdong Province from 2016 to 2020[J]. Chin J Parasitol Parasit Dis, 2022, 40(5): 629-634. (in Chinese)
[6]	张伟坚. 2015年佛山市顺德区人群肝吸虫感染状况及其流行因素[J]. 职业与健康, 2016, 32(12): 1662-1664.
	Zhang WJ. The infection status of liver flukes and its epidemiological factors among the population in Shunde District, Foshan City in 2015[J]. Occup and Health, 2016, 32(12): 1662-1664. (in Chinese)
[7]	李来德, 曾庆生, 梁健华, 等. 江门市新会区人群华支睾吸虫病感染现状调查分析[J]. 热带医学杂志, 2015, 15(7): 998-999.
	Li LD, Zeng QS, Liang JH, et al. Investigation and analysis of the current infection status of clonorchiasis sinensis among the population in Xinhui District, Jiangmen City[J]. J Trop Med, 2015, 15(7): 998-999. (in Chinese)
[8]	陈家旭, 蔡玉春, 艾琳, 等. 我国重要人体寄生虫病防控现状与挑战[J]. 检验医学, 2021, 36(10): 993-1000.
	Chen JX, Cai YC, Ai L, et al. Current status and challenges in the prevention and control of major human parasitic diseases in China[J]. Lab Med, 2021, 36(10): 993-1000. (in Chinese)
[9]	葛军, 姜唯声, 袁长红, 等. 江西省信丰县华支睾吸虫病综合防治示范区3年防治成效[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(5): 554-560.
	Ge J, Jiang WS, Yuan CH, et al. Three-year effectiveness of comprehensive prevention and control in a demonstration area for clonorchiasis sinensis in Xinfeng County, Jiangxi Province[J]. Chin J Parasitol Parasit Dis, 2020, 38(5): 554-560. (in Chinese)
[10]	文怡力, 黄友良, 王巍洁, 等. 新媒体环境下我国居民健康素养提升路径研究[J]. 医学信息学杂志, 2024, 45(6): 63-67.
	Wen YL, Huang YL, Wang WJ, et al. Research on the pathways to improve health literacy among Chinese residents in the context of new media[J]. J Med Inf, 2024, 45(6): 63-67. (in Chinese)
[11]	黄新华, 李志奇, 方悦怡, 等. 2006—2009年阳山县华支睾吸虫病示范区综合防治效果[J]. 中国血吸虫病防治杂志, 2011, 23(5): 569-570.
	Huang XH, Li ZQ, Fang YY, et al. Comprehensive prevention and control effects in a demonstration area for clonorchiasis sinensis in Yangshan County from 2006 to 2009[J]. Chin J Schisto Control, 2011, 23(5): 569-570. (in Chinese)
[12]	Deng Z, Fang Y, Zhang Q, et al. The control of clonorchiasis in Guangdong Province, southern China[J]. Acta tropica, 2020, 202: 105246.
[13]	黄哲, 黄家娣, 陈明, 等. 阿苯达唑两种用药方案治疗华支睾吸虫感染的疗效比较[J]. 广东医学, 2019, 40(13): 1928-1931.
	Huang Z, Huang JD, Chen M, et al. Comparative efficacy of two albendazole treatment regimens for Clonorchis sinensis infection[J]. Guangdong Med J, 2019, 40(13): 1928-1931. (in Chinese)
[14]	方悦怡, 阮彩文, 高向雄, 等. 华支睾吸虫病不同流行程度地区化疗措施的探索[J]. 中国血吸虫病防治杂志, 2014, 26(3): 300-302.
	Fang YY, Ruan CW, Gao XX, et al. Exploration of chemotherapy measures in areas with different levels of clonorchiasis sinensis endemicity[J]. Chin J Schisto Control, 2014, 26(3): 300-302. (in Chinese)
[15]	Li Z, Xin H, Qian M, et al. Clonorchis sinensis reinfection rate and reinfection determinants: A prospective cohort study in Hengxian County, Guangxi, China[J]. J Infect Dis, 2022, 225(3): 481-491.
[16]	Fang Y, Wang J, He G, et al. Long-term trend analysis of major human helminth infections: Guangdong Province, China, 1988-2021[J]. China CDC wkly, 2022, 4(41): 912-919.
[17]	袁爽, 唐磊, 葛涛, 等. 2020年黑龙江省肝吸虫感染状况分析[J]. 医学动物防制, 2023, 39(2): 195-197.
	Yuan S, Tang L, Ge T, et al. Analysis of liver fluke infection status in Heilongjiang Province in 2020[J]. J Med Pest Control, 2023, 39(2): 195-197. (in Chinese)

特征 Feature	中山市 Zhongshan City						新会区 Xinhui District
	基线调查^a Baseline investigation^a			终期评估调查 Final evaluation investigation			基线调查^a Baseline investigation^a			终期评估调查 Final evaluation investigation
	检查人数 No. exam’d	感染人数 No. infected	感染率/% Infection rate/%	检查人数 No. exam’d	感染人数 No. infected	感染率/% Infection rate/%	检查人数 No. exam’d	感染人数 No. infected	感染率/% Infection rate/%	检查人数 No. exam’d	感染人数 No. infected	感染率/% Infection rate/%
性别 Gender
男性 Male	547	228	41.68	504	86	17.06	770	344	44.68	478	62	12.97
女性 Female	526	172	32.70	633	45	7.11	690	155	22.46	522	40	7.66
年龄组/岁 Age Group/years
≤ 10	120	14	11.67	265	1	0.38	104	13	12.50	75	4	5.33
11~20	98	25	25.51	31	0	0	155	20	12.90	98	6	6.12
21~30	169	51	30.18	100	4	4.00	116	34	29.31	51	4	7.84
31~40	198	64	32.32	300	36	12.00	275	80	29.09	158	22	13.92
41~50	168	81	48.21	224	43	19.20	333	124	37.24	148	23	15.54
51~60	167	80	47.90	149	32	21.48	278	127	45.68	144	15	10.42
61~70	116	70	60.34	44	11	25.00	140	64	45.71	182	18	9.89
> 70	37	15	40.54	24	4	16.67	59	37	62.71	144	10	6.94
P（χ²）			< 0.05(88.42)^b			< 0.05(77.83)^c			< 0.05(104.67)^d			> 0.05(12.64)

广东省华支睾吸虫病综合防治项目防治成效评价

Evaluation of the effectiveness of the integrated clonorchiasis control programme in Guangdong Province

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[11]	葛军, 姜唯声, 袁长红, 诸廷俊, 陈喆, 杨玉华, 蓝明兴, 戴坤教, 李东, 曾小军, 陈颖丹. 江西省信丰县华支睾吸虫病综合防治示范区3年防治成效[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(5): 554-560.
[12]	陈喆, 叶斌, 姜唯声, 杨玉华, 赖博文, 曾小军, 周长海. 2016年江西省信丰县人群华支睾吸虫病知信行及影响因素分析[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(5): 567-573.
[13]	诸廷俊, 钱门宝, 陈颖丹, 陈喆, 葛军, 曾小军, 袁长红, 蓝明兴, 李石柱. 江西省信丰县小学华支睾吸虫病健康教育效果评价[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(5): 574-579.
[14]	王心, 王本贺, 王姝雅, 尹强, 徐长喜. 2015年吉林省人群华支睾吸虫感染现状调查[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(3): 291-295.
[15]	钱门宝, 蒋智华, 葛涛, 王心, 邓卓晖, 周长海, 朱慧慧, 陈颖丹, 周晓农. 生食淡水鱼行为传播华支睾吸虫病的效应分析[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(3): 296-301.