肝多房棘球蚴病免疫微环境异质性及其对疾病进展的影响

doi:10.12140/j.issn.1000-7423.2025.04.020

中国寄生虫学与寄生虫病杂志 ›› 2025, Vol. 43 ›› Issue (4): 581-587.doi: 10.12140/j.issn.1000-7423.2025.04.020

肝多房棘球蚴病免疫微环境异质性及其对疾病进展的影响

石大林¹^,²^,³()(), 庞明泉¹^,², 毋德芳¹^,², 许晓磊¹^,², 王成¹^,², 樊海宁¹^,²^,^*()()

1 青海大学附属医院，青海西宁 810001
2 青海省棘球蚴病研究重点实验室，青海西宁 810001
3 青海大学高原医学研究中心，青海西宁 810001

收稿日期:2024-12-11 修回日期:2025-02-25 出版日期:2025-08-30 发布日期:2025-10-09
通讯作者: *樊海宁（ORCID：0000-0001-5313-5732），男，博士，主任医师，从事肝胆胰外科临床与基础研究。E-mail：fanhaining@medmail.com.cn
作者简介:石大林（ORCID：0009-0005-4067-4944），男，博士，检验技师，从事棘球蚴病临床与基础研究工作。E-mail: dalin_shi@126.com
基金资助:
青海科技厅2022年科技计划项目（青海省棘球蚴病研究重点实验室）;青海大学附属医院肝胆外科（棘球蚴病）国家临床重点专科建设项目（青卫健办-125号）;青海大学附属医院中青年科研基金一般项目(ASRF-2023-YB-03)

Heterogeneity of the immune microenvironment in hepatic alveolar echinococcosis and its impact on disease progression

SHI Dalin¹^,²^,³()(), PANG Mingquan¹^,², WU Defang¹^,², XU Xiaolei¹^,², WANG Cheng¹^,², FAN Haining¹^,²^,^*()()

1 Qinghai University Affiliated Hospital, Xining 810001, Qinghai, China
2 Qinghai Province Key Laboratory of Hydatid Disease Research, Xining 810001, Qinghai, China
3 Research Center for High Altitude Medicine, Qinghai University, Xining 810001, Qinghai, China

Received:2024-12-11 Revised:2025-02-25 Online:2025-08-30 Published:2025-10-09
Contact: *E-mail: fanhaining@medmail.com.cn
Supported by:
Qinghai Science and Technology Department 2022 Science and Technology Project (Qinghai Key Laboratory of Echinococcosis Research);National Clinical Key Specialty Construction Project for Hepatobiliary Surgery (Hydatid Disease) at the Affiliated Hospital of Qinghai University (Qinghai Health Commission No. 125);Qinghai University Affiliated Hospital Young and Middle-Aged Research Fund General Project(ASRF-2023-YB-03)

摘要/Abstract

摘要：

肝多房棘球蚴病（HAE）是一种由多房棘球绦虫幼虫感染肝脏引发的严重寄生虫病，具有高致残率和病死率，严重威胁人类和动物的健康。近年来的研究发现HAE的免疫微环境具有显著的异质性，不仅影响了宿主对寄生虫的免疫应答，也对病程的发展和临床表现产生重要影响。本文从免疫微环境异质性的角度综述了HAE免疫微环境的最新研究进展，探讨其对疾病进展的影响，并展望未来的研究方向。

关键词: 肝多房棘球蚴病, 免疫微环境, 异质性, 疾病进展

Abstract:

Hepatic alveolar echinococcosis (HAE), a severe parasitic disease caused by Echinococcus multilocularis larvae infections in the liver, is characterized by high rates of disability and mortality and poses a great threat to both human and animal health. It has been recently found that the immune microenvironment in HAE exhibits considerable heterogeneity, which not only influences host immune responses to parasites, but also poses important impacts on disease progression and clinical manifestations. This article reviews the latest advances in the immune microenvironment of HAE from the perspective of immune microenvironment heterogeneity, discusses the impact on disease progression and proposes future research directions.

Key words: Hepatic alveolar echinococcosis, Immune microenvironment, Heterogeneity, Disease progression

中图分类号:

R532.32

石大林, 庞明泉, 毋德芳, 许晓磊, 王成, 樊海宁. 肝多房棘球蚴病免疫微环境异质性及其对疾病进展的影响[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(4): 581-587.

SHI Dalin, PANG Mingquan, WU Defang, XU Xiaolei, WANG Cheng, FAN Haining. Heterogeneity of the immune microenvironment in hepatic alveolar echinococcosis and its impact on disease progression[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2025, 43(4): 581-587.

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肝多房棘球蚴病免疫微环境异质性及其对疾病进展的影响

Heterogeneity of the immune microenvironment in hepatic alveolar echinococcosis and its impact on disease progression

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