2021—2022年山东省土源性线虫感染监测结果分析

doi:10.12140/j.issn.1000-7423.2024.04.018

中国寄生虫学与寄生虫病杂志 ›› 2024, Vol. 42 ›› Issue (4): 537-541.doi: 10.12140/j.issn.1000-7423.2024.04.018

2021—2022年山东省土源性线虫感染监测结果分析

王龙江(), 许艳, 孙慧, 李曰进, 卜灿灿, 吕文祥, 张本光, 孔祥礼, 闫歌, 王用斌^*()

山东省寄生虫病防治研究所，山东第一医科大学（山东省医学科学院），山东济宁 272033

收稿日期:2024-01-31 修回日期:2024-05-19 出版日期:2024-08-30 发布日期:2024-06-25
通讯作者: *王用斌（1979—），男，硕士，副研究员，从事寄生虫病防治研究。E-mail：aveo226@163.com
作者简介:王龙江（1988—），男，硕士，助理研究员，从事寄生虫病防治研究。E-mail：ljwang880108@163.com
基金资助:
山东省医药卫生科技发展计划项目(202201050165);山东省医药卫生科技发展计划项目(202301050242)

Analysis on surveillance of soil-transmitted nematode infections in Shandong Province from 2021 to 2022

WANG Longjiang(), XU Yan, SUN Hui, LI Yuejin, BU Cancan, LV Wenxiang, ZHANG Benguang, KONG Xiangli, YAN Ge, WANG Yongbin^*()

Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jining 272033, Shandong, China

Received:2024-01-31 Revised:2024-05-19 Online:2024-08-30 Published:2024-06-25
Contact: *E-mail: aveo226@163.com
Supported by:
Shandong Medical and Health and Science and Technology Development Project(202201050165);Shandong Medical and Health and Science and Technology Development Project(202301050242)

摘要/Abstract

摘要：

为了解山东省人体土源性线虫感染现状，为优化防控策略提供科学依据，2021—2022年采取整群抽样方法随机抽取山东省27个县（市、区）作为监测点，各监测点按地理方位划分为东、西、南、北、中5个片区，每片区随机抽取1个乡镇的1个行政村，每行政村3周岁以上常住人口抽取不少于200人作为监测对象。收集监测对象的基本信息及粪便样品，用改良加藤厚涂片法（Kato-Katz法，一粪二检）检测蠕虫卵并计数，试管滤纸培养法鉴别钩虫虫种，透明胶纸肛拭法检查3~9岁儿童蛲虫感染情况。建立数据库，利用SPSS 26.0软件进行统计分析，计算感染率、感染度，感染率间的比较采用卡方检验。2021—2022年共检测29 622人，土源性线虫总感染率为0.55%（162/29 622）。钩虫、蛔虫、鞭虫的感染率分别为0.02%（7/29 622）、0.02%（6/29 622）、0.51%（152/29 622），钩虫经培养鉴定均为十二指肠钩虫。152名鞭虫感染者中，重度感染2人，中度感染6人，其余均为轻度感染；6名蛔虫感染者和7名钩虫感染者均为轻度感染。鲁南、鲁东、鲁西北、鲁中地区土源性线虫感染率分别为0.97%（118/12 208）、0.84%（43/5 117）、0.01%（1/7 140）、0（0/5 157）。男性、女性土源性线虫感染率分别为0.55%（79/14 362）和0.54%（83/15 260）（χ² = 0.005，P > 0.05）；各年龄组中，60~99岁组土源性线虫感染率最高，为1.11%（107/9 612）（χ² = 86.274，P < 0.05）；各职业中，农民土源性线虫感染率最高，为0.78%（148/18 863）（χ² = 54.078，P < 0.05）；不同文化程度人群中，文盲/半文盲人群土源性线虫感染率最高，为2.43%（60/2 468）（χ² = 175.458，P < 0.05）。共检测2 584名儿童，蛲虫感染率为1.16%（30/2 584）。男童、女童蛲虫感染率分别为1.60%（22/1 375）、0.66%（8/1 209）（χ² = 4.936，P < 0.05）；各年龄中7岁组儿童感染率最高，为4.50%（15/333）（χ² = 39.798，P < 0.05）。山东省土源性线虫感染呈现地区、人群分布不均衡的特征，提示今后应在土源性线虫病监测的基础上，加强重点地区的防治，做好重点人群健康宣教，持续降低人群感染率。

关键词: 土源性线虫, 感染率, 监测, 山东省

Abstract:

In order to understand the current situation of soil-transmitted nematode infections in humans in Shandong Province and provide the scientific basis for optimizing prevention and control strategies, from 2021 to 2022, 27 counties in Shandong Province were randomly selected as surveillance sites. Each surveillance site was divided into five regions (east, west, south, north, and central) based on geography, and one administrative village from one township was randomly selected in each region. A total of 200 permanent residents with an age of over 3 years were taken as the surveillance object from each village by cluster sampling method. Basic information and the fecal samples were collected, and the worm eggs were examined in duplicates using the modified Kato-Katz thick smear method (one sample, two slide-readings) and counted. Hookworm species were identified using the tube filter paper culture technique. Children aged 3-9 years old were tested for Enterobius termicularis by anal transparent tape. A database was established, and SPSS 26.0 software was used to perform the statistical analysis. The infection rate and Infectivity were calculated. The infection rates were analyzed using the Chi-square test. A total of 29 622 people were detected in the province in 2021-2022, and the total infection rate of soil-transmitted nematode was 0.55% (162/29 622). The infection rates of hookworm, Ascaris lumbricoides and Trichuris trichiura were 0.02% (7/29 622), 0.02% (6/29 622) and 0.51% (152/29 622), respectively. The hookworm samples were all identified as Ancylostoma duodenale. Among the 152 trichuriasis patients, 2 were severely infected, 6 were moderately infected, and the rest were slightly infected. Six A. lumbricoides infections and seven hookworm infections were mild infections. The prevalence of soil-transmitted nematode was 0.97% (118/12 208), 0.84% (43/5 117), 0.01% (1/7 140), 0 (0/5 157) in southern, eastern, northwestern and central Shandong. The infection rate of soil-transmitted nematode was 0.55% (79/14 362) in males and 0.54% (83/15 260) in females (χ² = 0.005, P > 0.05). The age group of 60-99 had the highest infection rate among all age groups accounting for 1.11% (107/9 612) (χ² = 86.274, P > 0.05). Farmers had the highest infection rate among different occupational groups, accounting for 0.78% (148/18 863) (χ² = 54.078, P < 0.05). The illiterate or semi-illiterate group had the highest infection rate among different education levels, accounting for 2.43% (60/2 468) (χ² = 175.458, P < 0.05). A total of 2 584 children were examined, and the infection rate of E. vermicularis was 1.16% (30/2 584). The infection rate in boys and girls was 1.60% (22/1 375), 0.66% (8/1 209) (χ² = 4.936, P < 0.05). The highest rate was found in 7-year-old children, accounting for 4.50% (15/333) (χ² = 39.798, P < 0.05). The distribution of soil-transmitted nematode in Shandong Province was unbalanced among regions and populations, which indicated that the prevention and control of soil-transmitted nematode should be strengthened in key areas and carry out effective health education for key populations to reduce the infection rate continuously.

Key words: Soil-transmitted nematode, Infection rate, Surveillance, Shandong Province

中图分类号:

R532.1

王龙江, 许艳, 孙慧, 李曰进, 卜灿灿, 吕文祥, 张本光, 孔祥礼, 闫歌, 王用斌. 2021—2022年山东省土源性线虫感染监测结果分析[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(4): 537-541.

WANG Longjiang, XU Yan, SUN Hui, LI Yuejin, BU Cancan, LV Wenxiang, ZHANG Benguang, KONG Xiangli, YAN Ge, WANG Yongbin. Analysis on surveillance of soil-transmitted nematode infections in Shandong Province from 2021 to 2022[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2024, 42(4): 537-541.

图/表 3

表1

表2

图1

参考文献 22

[1]	Zhu YG, Zhao ZP, Kou JX, et al. Human parasite distribution in Shandong Province[J]. Chin J Parasitol Parasit Dis, 1994, 12(S1): 54-58. (in Chinese)
	(朱育光, 赵中平, 寇景轩, 等. 山东省人体寄生虫分布调查[J]. 中国寄生虫学与寄生虫病杂志, 1994, 12(S1): 54-58.)
[2]	Wan GQ, Liu X, Wang LL, et al. Present condition and characteristics of human intestinal parasites in Shandong Province[J]. Chin J Schisto Control, 2006, 18(5): 381-383. (in Chinese)
	(万功群, 刘新, 王利磊, 等. 山东省人体肠道寄生虫感染现状及特点[J]. 中国血吸虫病防治杂志, 2006, 18(5): 381-383.)
[3]	Liu X, Miao F, Deng XL, et al. Control strategy and practice of soil-transmitted parasitic diseases in Shandong Province[J]. Chin J Schisto Control, 2013, 25(1): 76-79. (in Chinese)
	(刘新, 缪峰, 邓绪礼, 等. 山东省土源性线虫病防控策略和实践[J]. 中国血吸虫病防治杂志, 2013, 25(1): 76-79.)
[4]	Wan GQ, Fu B, Li DJ, et al. Analysis of epidemic factors of clonorchiasis in Shandong Province[J]. Endem Dis Bull China, 2002, 17(1): 27-30. (in Chinese)
	(万功群, 傅斌, 李登俊, 等. 山东省华支睾吸虫病及流行因素分析[J]. 地方病通报, 2002, 17(1): 27-30.)
[5]	Xu Y, Bu XQ, Zhang DB, et al. Current status of intestinal parasite infections in rural areas of Shandong Province, China in 2015[J]. Chin J Parasitol Parasit Dis, 2019, 37(3): 260-265. (in Chinese)
	(许艳, 卜秀芹, 张佃波, 等. 2015年山东省农村地区人体肠道寄生虫感染现状调查[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(3): 260-265.) doi: 10.12140/j.issn.1000-7423.2019.03.004
[6]	Li YM, Li R, Yu T, et al. Formation and significance of literature on prevention and control of parasitic diseases in Shandong Province[J]. Chin J Zoonoses, 2018, 34(9): 839-844. (in Chinese)
	(李玉民, 李冉, 于涛, 等. 山东省寄生虫病防治文献资料的形成及意义[J]. 中国人兽共患病学报, 2018, 34(9): 839-844.)
[7]	Zhu HH, Zhou CH, Chen YD, et al. SWOT analysis of the national survey on current status of major human parasitic diseases in China[J]. Chin J Parasitol Parasit Dis, 2015, 33(5): 377-381. (in Chinese)
	(朱慧慧, 周长海, 陈颖丹, 等. 全国人体重点寄生虫病现状调查SWOT分析[J]. 中国寄生虫学与寄生虫病杂志, 2015, 33(5): 377-381.)
[8]	Zhu HH, Huang JL, Chen YD, et al. Analysis on endemic status of soil-transmitted nematode infection in China in 2019[J]. Chin J Parasitol Parasit Dis, 2021, 39(5): 666-673. (in Chinese)
	(朱慧慧, 黄继磊, 陈颖丹, 等. 2019年全国土源性线虫感染状况分析[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(5): 666-673.) doi: 10.12140/j.issn.1000-7423.2021.05.015
[9]	Wang YB, Xu Y, Kong XL, et al. Survey of intestinal parasitic infections and related knowledge and behavior of residents in Jiaodong Area of Shandong Province[J]. Chin J Schisto Control, 2014, 26(4): 376-381. (in Chinese)
	(王用斌, 许艳, 孔祥礼, 等. 山东省胶东地区居民肠道寄生虫感染及相关认知行为状况调查[J]. 中国血吸虫病防治杂志, 2014, 26(4): 376-381.)
[10]	Zhang HW, Xu BL, Zhao XD, et al. Investigation on intestinal parasitism and its socioeconomic factors in Henan Province[J]. Int J Med Parasit Dis, 2006, 33(4): 174-176. (in Chinese)
	(张红卫, 许汴利, 赵旭东, 等. 河南省肠道寄生虫感染及其社会经济因素调查[J]. 国际医学寄生虫病杂志, 2006, 33(4): 174-176.)
[11]	Zhu TJ, Chen YD, Xu LQ. Prevention and treatment of ascariasis in demonstration plots of integrated control from 2006 to 2009[J]. Chin J Schisto Control, 2011, 23(5): 490-494. (in Chinese)
	(诸廷俊, 陈颖丹, 许隆祺. 我国寄生虫病综合防治示范区蛔虫病3年防治效果[J]. 中国血吸虫病防治杂志, 2011, 23(5): 490-494.)
[12]	Zhang WP, Liu MX, Yin WH, et al. Evaluation of a long term effect on improving drinking water and lavatories in rural areas for prevention of diseases[J]. Chin J Dis Control Prev, 2000, 4(1): 76-78. (in Chinese)
	(张文平, 刘明欣, 尹文和, 等. 农村改水改厕远期卫生防病效果评价[J]. 疾病控制杂志, 2000, 4(1): 76-78.)
[13]	Zhu HH, Huang JL, Zhu TJ, et al. National surveillance of soil-transmitted helminth infections in 2017[J]. Chin J Parasitol Parasit Dis, 2019, 37(1): 12-17. (in Chinese)
	(朱慧慧, 黄继磊, 诸廷俊, 等. 2017年全国土源性线虫感染监测数据分析[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(1): 12-17.) doi: 10.12140/j.issn.1000-7423.2019.01.003
[14]	Xu Y, Miao F, Kong XL, et al. Survey of infections of intestinal parasites and related factors in north-west Shandong Province[J]. Chin J Schisto Control, 2014, 26(5): 534-537, 546. (in Chinese)
	(许艳, 缪峰, 孔祥礼, 等. 鲁西北地区居民肠道寄生虫感染及相关因素调查[J]. 中国血吸虫病防治杂志, 2014, 26(5): 534-537, 546.)
[15]	Zhang Q, Chen YD, Xu LQ, et al. Application and evaluation on five health education patterns of integrated control for parasitic diseases[J]. Chin J Schisto Control, 2011, 23(5): 510-514. (in Chinese)
	(张倩, 陈颖丹, 许隆祺, 等. 寄生虫病综合防治5种健康教育传播方式的应用与效果[J]. 中国血吸虫病防治杂志, 2011, 23(5): 510-514.)
[16]	Li BF, Wu FW, Yan XL, et al. Survey of human Trichuristrichiura infection in Yunnan[J]. China Trop Med, 2021, 21(3): 259-263. (in Chinese)
	(李奔福, 吴方伟, 严信留, 等. 云南省人体鞭虫感染状况调查[J]. 中国热带医学, 2021, 21(3): 259-263.) doi: 10.13604/j.cnki.46-1064/r.2021.03.14
[17]	Wang WZ, Liu X, Deng XL, et al. Investigation on soil-transmitted nematode and liver fluke infections of Shandong receiving water regions by South-to-North Water Diversion[J]. China Trop Med, 2009(1): 34-36. (in Chinese)
	(王文志, 刘新, 邓绪礼, 等. 南水北调山东受水区人体重要寄生虫感染基线调查[J]. 中国热带医学, 2009(1):34-36.)
[18]	Zeng XJ, Li ZJ, Jiang WS, et al. Survey of epidemic status of principal human parasites in Jiangxi Province in 2014[J]. Chin J Schisto Control, 2015, 27(6): 595-599. (in Chinese)
	(曾小军, 李召军, 姜唯声, 等. 2014年江西省人体重点寄生虫感染现状[J]. 中国血吸虫病防治杂志, 2015, 27(6): 595-599.)
[19]	Li SS, Luo F, Xie J, et al. Survey and analysis of major human parasitic diseases in Chongqing City[J]. Chin J Schisto Control, 2018, 30(2): 194-199. (in Chinese)
	(李珊珊, 罗飞, 谢君, 等. 重庆市人体重点寄生虫病现状调查与分析[J]. 中国血吸虫病防治杂志, 2018, 30(2): 194-199.)
[20]	Li XM, Chen YD, Xu LQ, et al. Study on a new prevention and control model on soil-borne parasitic diseases in rural areas of China[J]. Chin J Schisto Control, 2011, 23(6): 719-721. (in Chinese)
	(黎学铭, 陈颖丹, 许隆祺, 等. 我国农村土源性寄生虫病防治新模式探讨[J]. 中国血吸虫病防治杂志, 2011, 23(6): 719-721.)
[21]	Zhang MZ, Huang JL, Zhu HH, et al. Epidemiological analysis of soil-transmitted nematode infections in China in 2020[J]. Chin J Parasitol Parasit Dis, 2023, 41(3): 331-335, 343. (in Chinese)
	(张米禛, 黄继磊, 朱慧慧, 等. 2020年全国人体土源性线虫感染情况分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(3): 331-335, 343.) doi: 10.12140/j.issn.1000-7423.2023.03.011
[22]	Zhang J, Lin DD. Health education for major parasitic diseases in rural community of China: current status and future development[J]. Chin J Schisto Control, 2013, 25(4): 333-336. (in Chinese)
	(张晶, 林丹丹. 我国农村地区重点寄生虫病健康教育现状及发展方向的思考[J]. 中国血吸虫病防治杂志, 2013, 25(4): 333-336.)

地区	市	县（市、区）	感染率/%（感染人数/调查人数）
鲁中	济南市	槐荫区	0(0/1 018)
	济南市	历下区	0(0/1 120)
	淄博市	桓台县	0(0/1 009)
	潍坊市	坊子区	0(0/1 009)
	潍坊市	潍城区	0(0/1 001)
鲁南	临沂市	莒南县	1.74(35/2 017)
		罗庄区	0.20(2/1 009)
		平邑县	0.20(2/1 020)
	济宁市	兖州区	0.10(1/1 043)
	济宁市	鱼台县	0.05(1/2 055)
	菏泽市	成武县	0(0/1 013)
	菏泽市	定陶区	0(0/1 036)
	日照市	岚山区	7.61(77/1 012)
	枣庄市	山亭区	0(0/1 002)
	枣庄市	滕州市	0(0/1 001)
鲁东	青岛市	崂山区	0.30(3/1000)
	青岛市	西海岸新区	0(0/1 000)
	威海市	乳山市	1.96(20/1 022)
	烟台市	福山区	0.18(2/1 083)
	烟台市	海阳市	1.78(18/1 012)
鲁西北	滨州市	博兴县	0(0/1 033)
	滨州市	无棣县	0.10(1/1 007)
	德州市	德城区	0(0/1 025)
	德州市	宁津县	0(0/1 011)
	东营市	河口区	0(0/1 010)
	聊城市	高唐县	0(0/1 042)
	聊城市	冠县	0(0/1 012)

2021—2022年山东省土源性线虫感染监测结果分析

Analysis on surveillance of soil-transmitted nematode infections in Shandong Province from 2021 to 2022

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 3

参考文献 22

相关文章 15

编辑推荐

Metrics

本文评价

特征	调查人数	感染人数	感染率/%	χ²	P
性别
男	14 632	79	0.55	0.005	> 0.05
女	15 260	83	0.54	0.005	> 0.05
年龄组/岁
3~9	3 676	6	0.16	86.274	< 0.05
10~19	3 493	6	0.17
20~59	12 841	43	0.33
60~99	9 612	107	1.11
职业
农民	18 863	148	0.78	54.078	< 0.05
学生	7 512	11	0.15
其他	3 247	3	0.09
文化程度
学龄前儿童	2 113	3	0.14	175.458	< 0.05
小学	9 515	42	0.44
初中	10 772	45	0.42
高中、中专	3 161	12	0.38
大专及以上	1 593	0	0
文盲或半文盲	2 468	60	2.43

[1]	柴应植, 陈华良, 余可根, 张轩, 王笑笑, 张家祺, 徐文婕, 阮卫. 2013—2022年浙江省华支睾吸虫感染监测结果分析[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(4): 469-474.
[2]	甘立勤, 李媛, 刘武艺, 梁享生, 黄达娜, 高世同. 2018—2023年深圳市龙岗区输入性疟疾疫情特征[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(4): 533-536.
[3]	许艳, 王龙江, 孔祥礼, 李曰进, 卜灿灿, 闫歌, 张本光, 王用斌. 2017—2022年山东省输入性疟疾流行病学特征[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(2): 140-146.
[4]	严信留, 杜尊伟, 杨亚明, 汪丽波, 吴方伟, 李奔福, 李鸿斌, 陈然, 字金荣, 彭佳, 蔡璇, 保雪莹, 唐小英, 杨恒林. 单次和双次阿苯达唑治疗土源性线虫感染的疗效观察[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(2): 204-210.
[5]	朱民, 张浩, 吴立明, 张宸罡, 张耀光, 王真瑜, 陈健, 吴寰宇, 陈昕. 上海市消除疟疾后输入性疟疾监测响应系统实施与成效分析[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(1): 91-97.
[6]	吴方伟, 彭佳, 字金荣, 李奔福, 严信留, 蔡璇, 王正青, 徐倩, 李建雄, 杨亚明. 2016—2022年云南省土源性线虫感染监测结果分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(6): 718-724.
[7]	李琳, 朱爱娅, 蔡玉春, 俞铖航, 陈木新, 田利光. 黔东南地区侗族人群芽囊原虫感染情况及影响因素分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(6): 725-732.
[8]	段承丽, 何冬梅, 杨舒, 张妍黎, 罗自荣, 雄碧才, 字金荣, 彭佳, 吴方伟. 2016—2021年云南省贡山县人群土源性线虫感染监测结果分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(6): 766-771.
[9]	郑玉华, 帖萍, 白永飞, 闫昌福, 王婷, 王晶莹, 田晓东, 代培芳. 2021—2022年山西省内脏利什曼病流行区家犬感染情况及白蛉密度调查[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(4): 470-475.
[10]	王威, 蔡辉霞. 2020年青海省棘球蚴病监测结果[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(3): 319-324.
[11]	张米禛, 黄继磊, 朱慧慧, 周长海, 诸廷俊, 钱门宝, 陈颖丹, 李石柱. 2020年全国人体土源性线虫感染情况分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(3): 331-335.
[12]	陈朱云, 欧阳榕, 肖丽贞, 林耀莹, 谢汉国, 张山鹰. 福建省疟疾消除后基层监测响应系统现况分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(2): 170-175.
[13]	罗静雯, 田洪春, 铁磊, 张丽萍, 谢红, 龚希, 吴小红, 邓秀. 2016—2021年四川省人群土源性线虫感染情况分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(2): 192-197.
[14]	操治国, 汪天平, 金伟, 郭见多, 朱磊, 刘道华, 汪敏, 李启扬, 呼明闯. “十三五”期间安徽省人群土源性线虫感染监测结果分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(1): 44-51.
[15]	陈喆, 葛军, 姜唯声, 邱婷婷, 温琪, 曾小军. 2015—2021年江西省人群土源性线虫感染流行趋势分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(1): 59-67.