媒介蚊虫的嗅觉发生和性别决定

doi:10.12140/j.issn.1000-7423.2021.01.001

中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (1): 1-7.doi: 10.12140/j.issn.1000-7423.2021.01.001

媒介蚊虫的嗅觉发生和性别决定

刘通(), 吴恙, 刘培文, 杨文强, 金彬彬, 顾金保, 陈晓光^*()

南方医科大学公共卫生学院热带医学研究所,广州 510515

收稿日期:2020-12-07 修回日期:2021-01-08 出版日期:2021-02-28 发布日期:2021-03-10
通讯作者: 陈晓光
作者简介:刘通（1989-）,博士后,从事蚊虫及其传染病的防控研究。E-mail： 729987610@qq.com
基金资助:
国家重点研发计划资助(2020YFC1200100);国家自然科学基金(31830087);国家自然科学基金(81829004);美国国家卫生研究所资助项目(AI136850);广州市科技计划项目(201807010005);广州市科技计划项目(201803040006)

Olfactory perception and sex determination of vector mosquitoes

LIU Tong(), WU Yang, LIU Pei-wen, YANG Wen-qiang, JIN Bin-bin, GU Jin-bao, CHEN Xiao-guang^*()

Institute of Tropical Medicine, Southern Medical University, Guangzhou 510515, China

Received:2020-12-07 Revised:2021-01-08 Online:2021-02-28 Published:2021-03-10
Contact: CHEN Xiao-guang
Supported by:
National Key R&D Program of China(2020YFC1200100);National Natural Science Foundation of China(31830087);National Natural Science Foundation of China(81829004);National Institutes of Health, USA(AI136850);Guangzhou Synergy Innovation Key Program for Health(201807010005);Guangzhou Synergy Innovation Key Program for Health(201803040006)

摘要/Abstract

摘要：

蚊虫是一类重要的媒介生物,雌蚊可以通过吸血传播多种疾病,如疟疾、登革热、流行性乙型脑炎等。蚊虫嗅觉发生和雌雄性别的决定对蚊虫的生存繁衍、疾病传播至关重要,往往也是控制蚊虫种群密度、防治蚊媒传染病的关键所在。本文综述了媒介蚊虫的嗅觉发生和性别决定的基本功能、作用机制及研究进展,以期为蚊虫种群密度控制、蚊媒传染病防治等提供参考依据。

关键词: 蚊虫, 嗅觉, 性别决定, 防制

Abstract:

Mosquitoe is a type of important vector organism. Female mosquitoes can transmit various infectious diseases such as malaria, dengue fever, and epidemic encephalitis B, through sucking blood. Mosquito olfactory perception and sex determination are essential for reproducing and transmitting pathogens and often critical for control of mosquito population density and mosquito-borne diseases. Herein, we review the basic functions, mechanisms, and research advances on olfactory perception and sex determination of vector mosquitoes, in order to provide reference for controlling mosquito population density and mosquito-borne diseases.

Key words: Mosquito, Olfactory perception, Sex determination, Vector control

中图分类号:

R384.11

刘通, 吴恙, 刘培文, 杨文强, 金彬彬, 顾金保, 陈晓光. 媒介蚊虫的嗅觉发生和性别决定[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(1): 1-7.

LIU Tong, WU Yang, LIU Pei-wen, YANG Wen-qiang, JIN Bin-bin, GU Jin-bao, CHEN Xiao-guang. Olfactory perception and sex determination of vector mosquitoes[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2021, 39(1): 1-7.

图/表 2

参考文献 81

[1]	Liu C, Pitts RJ, Bohbot JD, et al. Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae[J]. PLoS Biol, 2010,8(8):e1000467. doi: 10.1371/journal.pbio.1000467 pmid: 20824161
[2]	Lutz EK, Lahondère C, Vinauger C, et al. Olfactory learning and chemical ecology of olfaction in disease vector mosquitoes: a life history perspective[J]. Curr Opin Insect Sci, 2017,20:75-83. doi: 10.1016/j.cois.2017.03.002 pmid: 28602240
[3]	Chadee DD, Sutherland JM, Gilles JRL. Diel sugar feeding and reproductive behaviours of Aedes aegypti mosquitoes in Trinidad: with implications for mass release of sterile mosquitoes[J]. Acta Trop, 2014,132:S86-S90. doi: 10.1016/j.actatropica.2013.09.019
[4]	Barredo E, DeGennaro M. Not just from blood: mosquito nutrient acquisition from nectar sources[J]. Trends Parasitol, 2020,36(5):473-484. doi: 10.1016/j.pt.2020.02.003 pmid: 32298634
[5]	Vargo AM, Foster WA. Responsiveness of female Aedes aegypti (Diptera : Culicidae) to flower extracts[J]. J Med Entomol, 1982,19(6):710-718. doi: 10.1093/jmedent/19.6.710
[6]	Mauer DJ, Rowley WA. Attraction of Culex pipiens pipiens (Diptera : Culicidae) to flower volatiles[J]. J Med Entomol, 1999,36(4):503-507. doi: 10.1093/jmedent/36.4.503 pmid: 10467780
[7]	Otienoburu PE, Ebrahimi B, Phelan PL, et al. Analysis and optimization of a synthetic milkweed floral attractant for mosquitoes[J]. J Chem Ecol, 2012,38(7):873-881. doi: 10.1007/s10886-012-0150-6
[8]	Nyasembe VO, Torto B. Volatile phytochemicals as mosquito semiochemicals[J]. Phytochem Lett, 2014,8:196-201. doi: 10.1016/j.phytol.2013.10.003
[9]	Yu BT, Hu Y, Ding YM, et al. Feeding on different attractive flowering plants affects the energy reserves of Culex pipiens pallens adults[J]. Parasitol Res, 2018,117(1):67-73. doi: 10.1007/s00436-017-5664-y pmid: 29177970
[10]	Gouagna LC, Kerampran R, Lebon C, et al. Sugar-source preference, sugar intake and relative nutritional benefits in Anopheles arabiensis males[J]. Acta Trop, 2014,132:S70-S79. doi: 10.1016/j.actatropica.2013.09.022
[11]	Hapairai LK, Joseph H, Sang MA, et al. Field evaluation of selected traps and lures for monitoring the filarial and arbovirus vector, Aedes polynesiensis (Diptera : Culicidae), in French Polynesia[J]. J Med Entomol, 2013,50(4):731-739. doi: 10.1603/me12270 pmid: 23926770
[12]	Li Y, Su X, Zhou G, et al. Comparative evaluation of the efficiency of the BG-Sentinel trap, CDC light trap and Mosquito-oviposition trap for the surveillance of vector mosquitoes[J]. Parasit Vectors, 2016,9(1):446. doi: 10.1186/s13071-016-1724-x pmid: 27519419
[13]	Takken W, Costantini C, Dolo G, et al. Mosquito mating behaviour[M] //Bridging laboratory and field research for genetic control of disease vectors. Dordrecht: Springer Netherlands, 2006: 183-188.
[14]	Pitts RJ, Mozūraitis R, Gauvin-Bialecki A, et al. The roles of kairomones, synomones and pheromones in the chemically-mediated behaviour of male mosquitoes[J]. Acta Trop, 2014,132:S26-S34. doi: 10.1016/j.actatropica.2013.09.005
[15]	Cabrera M, Jaffe K. An aggregation pheromone modulates lekking behavior in the vector mosquito Aedes aegypti (Diptera : Culicidae)[J]. J Am Mosq Control Assoc, 2007,23(1):1-10. doi: 10.2987/8756-971X(2007)23[1:AAPMLB]2.0.CO;2 pmid: 17536361
[16]	Fawaz EY, Allan SA, Bernier UR, et al. Swarming mechanisms in the yellow fever mosquito: aggregation pheromones are involved in the mating behavior of Aedes aegypti[J]. J Vector Ecol, 2014,39(2):347-354. doi: 10.1111/jvec.12110
[17]	Anton S, van Loon JJ, Meijerink J, et al. Central projections of olfactory receptor neurons from single antennal and palpal sensilla in mosquitoes[J]. Arthropod Struct Dev, 2003,32(4):319-327. doi: 10.1016/j.asd.2003.09.002
[18]	Seenivasagan T, Sharma KR, Shrivastava A, et al. Surface morphology and morphometric analysis of sensilla of Asian tiger mosquito, Aedes albopictus (Skuse): an SEM investigation[J]. J Vector Borne Dis, 2009,46(2):125-135. pmid: 19502692
[19]	Matthews BJ, McBride CS, DeGennaro M, et al. The neurotranscriptome of the Aedes aegypti mosquito[J]. BMC Genom, 2016,17:32. doi: 10.1186/s12864-015-2239-0
[20]	Yan H, Jafari S, Pask G, et al. Evolution, developmental expression and function of odorant receptors in insects[J]. J Exp Biol, 2020, 223(pt suppl 1): jeb208215. doi: 10.1242/jeb.208215 pmid: 32034042
[21]	Gomez-Diaz C, Martin F, Garcia-Fernandez JM, et al. The two main olfactory receptor families in drosophila, ORs and IRs: a comparative approach[J]. Front Cell Neurosci, 2018,12:253. doi: 10.3389/fncel.2018.00253 pmid: 30214396
[22]	Leal WS. Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes[J]. Annu Rev Entomol, 2013,58:373-391. doi: 10.1146/annurev-ento-120811-153635
[23]	Carey AF, Wang GR, Su CY, et al. Odorant reception in the malaria mosquito Anopheles gambiae[J]. Nature, 2010,464(7285):66-71. doi: 10.1038/nature08834 pmid: 20130575
[24]	Carraher C, Dalziel J, Jordan MD, et al. Towards an understanding of the structural basis for insect olfaction by odorant receptors[J]. Insect Biochem Mol Biol, 2015,66:31-41. doi: 10.1016/j.ibmb.2015.09.010 pmid: 26416146
[25]	Wang GR, Carey AF, Carlson JR, et al. Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae[J]. Proc Natl Acad Sci USA, 2010,107(9):4418-4423. doi: 10.1073/pnas.0913392107 pmid: 20160092
[26]	Chen XG, Jiang X, Gu J, et al. Genome sequence of the Asian tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution[J]. Proc Natl Acad Sci USA, 2016,113(4):E489. doi: 10.1073/pnas.1524968113 pmid: 26787860
[27]	Matthews BJ, Dudchenko O, Kingan SB, et al. Improved reference genome of Aedes aegypti informs arbovirus vector control[J]. Nature, 2018,563(7732):501-507. doi: 10.1038/s41586-018-0692-z pmid: 30429615
[28]	Liu H, Liu T, Xie L, et al. Functional analysis of Orco and odorant receptors in odor recognition in Aedes albopictus[J]. Parasit Vectors, 2016,9(1):363. doi: 10.1186/s13071-016-1644-9 pmid: 27350348
[29]	Xu PX, Choo YM, de la Rosa A, et al. Mosquito odorant receptor for DEET and methyl jasmonate[J]. Proc Natl Acad Sci USA, 2014,111(46):16592-16597. doi: 10.1073/pnas.1417244111 pmid: 25349401
[30]	Jones PL, Pask GM, Rinker DC, et al. Functional agonism of insect odorant receptor ion channels[J]. Proc Natl Acad Sci USA, 2011,108(21):8821-8825. doi: 10.1073/pnas.1102425108 pmid: 21555561
[31]	DeGennaro M, McBride CS, Seeholzer L, et al. Orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET[J]. Nature, 2013,498(7455):487-491. doi: 10.1038/nature12206 pmid: 23719379
[32]	Raji JI, Melo N, Castillo JS, et al. Aedes aegypti mosquitoes detect acidic volatiles found in human odor using the IR8a pathway[J]. Curr Biol, 2019, 29(8): 1253-1262.e7. doi: 10.1016/j.cub.2019.02.045 pmid: 30930038
[33]	Hallem EA, Nicole Fox A, Zwiebel LJ, et al. Olfaction: mosquito receptor for human-sweat odorant[J]. Nature, 2004,427(6971):212-213. doi: 10.1038/427212a pmid: 14724626
[34]	Pitts RJ, Derryberry SL, Zhang Z, et al. Variant ionotropic receptors in the malaria vector mosquito Anopheles gambiae tuned to amines and carboxylic acids[J]. Sci Rep, 2017,7:40297. doi: 10.1038/srep40297 pmid: 28067294
[35]	Thireou T, Kythreoti G, Tsitsanou KE, et al. Identification of novel bioinspired synthetic mosquito repellents by combined ligand-based screening and OBP-structure-based molecular docking[J]. Insect Biochem Mol Biol, 2018,98:48-61. doi: 10.1016/j.ibmb.2018.05.001 pmid: 29751047
[36]	Kröber T, Koussis K, Bourquin M, et al. Odorant-binding protein-based identification of natural spatial repellents for the African malaria mosquito Anopheles gambiae[J]. Insect Biochem Mol Biol, 2018,96:36-50. doi: 10.1016/j.ibmb.2018.03.008 pmid: 29656020
[37]	Deng Y, Yan H, Gu J, et al. Molecular and functional characterization of odorant-binding protein genes in an invasive vector mosquito, Aedes albopictus[J]. PLoS One, 2013,8(7):e68836. doi: 10.1371/journal.pone.0068836 pmid: 23935894
[38]	McBride CS, Baier F, Omondi AB, et al. Evolution of mosquito preference for humans linked to an odorant receptor[J]. Nature, 2014,515(7526):222-227. doi: 10.1038/nature13964
[39]	Wu Q, Li CX, Liu QM, et al. RNA interference of odorant receptor CquiOR114/117 affects blood-feeding behavior in Culex quinquefasciatus[J]. Acta Trop, 2020,204:105343. doi: 10.1016/j.actatropica.2020.105343 pmid: 31954135
[40]	Pelletier J, Guidolin A, Syed Z, et al. Knockdown of a mosquito odorant-binding protein involved in the sensitive detection of oviposition attractants[J]. J Chem Ecol, 2010,36(3):245-248. doi: 10.1007/s10886-010-9762-x
[41]	Yin J, Choo YM, Duan H, et al. Selectivity of odorant-binding proteins from the southern house mosquito tested against physiologically relevant ligands[J]. Front Physiol, 2015,6:56. doi: 10.3389/fphys.2015.00056 pmid: 25774136
[42]	Wang Y, Li TT, Gong MQ. Advances in research on olfactory receptors of mosquitoes[J]. Chin J Parasitol Parasit Dis, 2020,38(5):647-652. (in Chinese)
	( 王洋, 李婷婷, 公茂庆. 蚊虫嗅觉受体研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020,38(5):647-652.)
[43]	Schorkopf DL, Spanoudis CG, Mboera LE, et al. Combining attractants and larvicides in biodegradable matrices for sustainable mosquito vector control[J]. PLoS Negl Trop Dis, 2016,10(10):e0005043. doi: 10.1371/journal.pntd.0005043 pmid: 27768698
[44]	Wondwosen B, Birgersson G, Tekie H, et al. Sweet attraction: sugarcane pollen-associated volatiles attract gravid Anopheles arabiensis[J]. Malar J, 2018,17(1):90. doi: 10.1186/s12936-018-2245-1 pmid: 29466989
[45]	Xie L, Yang W, Liu H, et al. Enhancing attraction of the vector mosquito Aedes albopictus by using a novel synthetic odorant blend[J]. Parasit Vectors, 2019,12(1):382. doi: 10.1186/s13071-019-3646-x pmid: 31362759
[46]	Batista EPA, Ngowo H, Opiyo M, et al. Field evaluation of the BG-Malaria trap for monitoring malaria vectors in rural Tanzanian villages[J]. PLoS One, 2018,13(10):e0205358. doi: 10.1371/journal.pone.0205358 pmid: 30296287
[47]	MacKay AJ, Amador M, Barrera R. An improved autocidal gravid ovitrap for the control and surveillance of Aedes aegypti[J]. Parasit Vectors, 2013,6:225. doi: 10.1186/1756-3305-6-225 pmid: 23919568
[48]	Stanczyk NM, Brookfield JF, Ignell R, et al. Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function[J]. Proc Natl Acad Sci USA, 2010,107(19):8575-8580. doi: 10.1073/pnas.1001313107 pmid: 20439757
[49]	Verhulst EC, van de Zande L, Beukeboom LW. Insect sex determination: it all evolves around transformer[J]. Curr Opin Genet Dev, 2010,20(4):376-383. doi: 10.1016/j.gde.2010.05.001
[50]	Day J. Mosquito oviposition behavior and vector control[J]. Insects, 2016,7(4):65. doi: 10.3390/insects7040065
[51]	Hall AB, Qi YM, Timoshevskiy V, et al. Six novel Y chromosome genes in Anopheles mosquitoes discovered by independently sequencing males and females[J]. BMC Genom, 2013,14:273. doi: 10.1186/1471-2164-14-273
[52]	Krzywinska E, Dennison NJ, Lycett GJ, et al. A maleness gene in the malaria mosquito Anopheles gambiae[J]. Science, 2016,353(6294):67-69. doi: 10.1126/science.aaf5605 pmid: 27365445
[53]	Criscione F, Qi Y, Tu Z. GUY1 confers complete female lethality and is a strong candidate for a male-determining factor in Anopheles stephensi[J]. Elife, 2016,5. doi: 10.7554/eLife.19706 pmid: 28009253
[54]	Qi Y, Wu Y, Saunders R, et al. Guy1, a Y-linked embryonic signal, regulates dosage compensation in Anopheles stephensi by increasing X gene expression[J]. Elife, 2019,8. doi: 10.7554/eLife.51163 pmid: 31868589
[55]	Hall AB, Basu S, Jiang X, et al. Sex determination. A male-determining factor in the mosquito Aedes aegypti[J]. Science, 2015,348(6240):1268-1270. doi: 10.1126/science.aaa2850 pmid: 25999371
[56]	Aryan A, Anderson MAE, Biedler JK, et al. Nix alone is sufficient to convert female Aedes aegypti into fertile males and myo-sex is needed for male flight[J]. Proc Natl Acad Sci USA, 2020,117(30):17702-17709. doi: 10.1073/pnas.2001132117 pmid: 32661163
[57]	Gomulski LM, Mariconti M, Di Cosimo A, et al. The Nix locus on the male-specific homologue of chromosome 1 in Aedes albopictus is a strong candidate for a male-determining factor[J]. Parasit Vectors, 2018,11(suppl 2):647. doi: 10.1186/s13071-018-3215-8 pmid: 30583734
[58]	Liu PW, Jin BB, Li XC, et al. Nix is a male-determining factor in the Asian tiger mosquito Aedes albopictus[J]. Insect Biochem Mol Biol, 2020,118:103311. doi: 10.1016/j.ibmb.2019.103311 pmid: 31901476
[59]	Jost E, Laven H. Meiosis in translocation heterozygotes in the mosquito Culex pipiens[J]. Chromosoma, 1971,35(2):184-205. doi: 10.1007/BF00285736 pmid: 5131761
[60]	Baker RH, Sakai RK. Triploids and male determination in the mosquito, Anopheles culicifacies[J]. J Hered, 1979,70(5):345-346. doi: 10.1093/oxfordjournals.jhered.a109271 pmid: 43343
[61]	Ferdig MT, Taft AS, Severson DW, et al. Development of a comparative genetic linkage map for Armigeres subalbatus using Aedes aegypti RFLP markers[J]. Genome Res, 1998,8(1):41-47. doi: 10.1101/gr.8.1.41 pmid: 9445486
[62]	Newton ME, Southern DI, Wood RJ. X and Y chromosomes of Aedes aegypti (L.) distinguished by Giemsa C-banding[J]. Chromosoma, 1974,49(1):41-49. doi: 10.1007/BF00284986 pmid: 4141301
[63]	Toups MA, Hahn MW. Retrogenes reveal the direction of sex-chromosome evolution in mosquitoes[J]. Genetics, 2010,186(2):763-766. doi: 10.1534/genetics.110.118794 pmid: 20660646
[64]	Motara MA, Rai KS. Chromosomal differentiation in two species of Aedes and their hybrids revealed by Giemsa C-banding[J]. Chromosoma, 1977,64(2):125-132. doi: 10.1007/BF00327052
[65]	Mori A, Tomita T, Hidoh O, et al. Comparative linkage map development and identification of an autosomal locus for insensitive acetylcholinesterase-mediated insecticide resistance in Culex tritaeniorhynchus[J]. Insect Mol Biol, 2001,10(3):197-203. doi: 10.1046/j.1365-2583.2001.00255.x pmid: 11437911
[66]	Malcolm CA, Bourguet D, Ascolillo A, et al. A sex-linked Ace gene, not linked to insensitive acetylcholinesterase-mediated insecticide resistance in Culex pipiens[J]. Insect Mol Biol, 1998,7(2):107-120. doi: 10.1046/j.1365-2583.1998.72055.x pmid: 9535157
[67]	Reidenbach KR, Cook S, Bertone MA, et al. Phylogenetic analysis and temporal diversification of mosquitoes (Diptera : Culicidae) based on nuclear genes and morphology[J]. BMC Evol Biol, 2009,9:298. doi: 10.1186/1471-2148-9-298 pmid: 20028549
[68]	Krzywinski J, Grushko OG, Besansky NJ. Analysis of the complete mitochondrial DNA from Anopheles funestus: an improved dipteran mitochondrial genome annotation and a temporal dimension of mosquito evolution[J]. Mol Phylogenetics Evol, 2006,39(2):417-423. doi: 10.1016/j.ympev.2006.01.006
[69]	Wang J, Na JK, Yu Q, et al. Sequencing Papaya X and Yh chromosomes reveals molecular basis of incipient sex chromosome evolution[J]. Proc Natl Acad Sci USA, 2012,109(34):13710-13715. doi: 10.1073/pnas.1207833109 pmid: 22869747
[70]	Hall AB, Papathanos PA, Sharma A, et al. Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes[J]. Proc Natl Acad Sci USA, 2016,113(15):E2114-E2123. doi: 10.1073/pnas.1525164113 pmid: 27035980
[71]	Criscione F, Qi Y, Saunders R, et al. A unique Y gene in the Asian malaria mosquito Anopheles stephensi encodes a small lysine-rich protein and is transcribed at the onset of embryonic development[J]. Insect Mol Biol, 2013,22(4):433-441. doi: 10.1111/imb.12034
[72]	Salz H, Erickson JW. Sex determination in Drosophila: the view from the top[J]. Fly, 2010,4(1):60-70. doi: 10.4161/fly.4.1.11277 pmid: 20160499
[73]	Biedler JK, Tu Z. Sex determination in mosquitoes[J]. Adv Insect Physiol, 2016,51:37-66.
[74]	Salvemini M, D’Amato R, Petrella V, et al. The orthologue of the fruitfly sex behaviour gene fruitless in the mosquito Aedes aegypti: evolution of genomic organisation and alternative splicing[J]. PLoS One, 2013,8(2):e48554. doi: 10.1371/journal.pone.0048554 pmid: 23418412
[75]	Scali C, Catteruccia F, Li Q, et al. Identification of sex-specific transcripts of the Anopheles gambiae doublesex gene[J]. J Exp Biol, 2005,208(pt 19):3701-3709. doi: 10.1242/jeb.01819 pmid: 16169947
[76]	Zheng X, Zhang D, Li Y, et al. Incompatible and sterile insect techniques combined eliminate mosquitoes[J]. Nature, 2019,572(7767):56-61. doi: 10.1038/s41586-019-1407-9 pmid: 31316207
[77]	Hammond A, Galizi R, Kyrou K, et al. A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae[J]. Nat Biotechnol, 2016,34(1):78-83. doi: 10.1038/nbt.3439 pmid: 26641531
[78]	Eckhoff PA, Wenger EA, Godfray HC, et al. Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics[J]. Proc Natl Acad Sci USA, 2017,114(2):E255-E264. doi: 10.1073/pnas.1611064114 pmid: 28028208
[79]	Crawford JE, Clarke DW, Criswell V, et al. Efficient production of male Wolbachia-infected Aedes aegypti mosquitoes enables large-scale suppression of wild populations[J]. Nat Biotechnol, 2020,38(4):482-492. doi: 10.1038/s41587-020-0471-x pmid: 32265562
[80]	Mains JW, Brelsfoard CL, Rose RI, et al. Female adult Aedes albopictus suppression by Wolbachia-infected male mosquitoes[J]. Sci Rep, 2016,6:33846. doi: 10.1038/srep33846 pmid: 27659038
[81]	Kyrou K, Hammond AM, Galizi R, et al. A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes[J]. Nat Biotechnol, 2018,36(11):1062-1066. doi: 10.1038/nbt.4245 pmid: 30247490

蚊种	基因家族	基因名称	相关行为	参考文献
冈比亚按蚊	ORs	Or1	人体气味	[33]
	IRs	Ir75k	含羧酸的化合物	[34]
	IRs	Ir76b	丁胺探测	[34]
	OBPs	Obp1	驱避剂	[35]
	OBPs	Obp1、3、4、5、20、47	植物驱避剂	[36]
白纹伊蚊	ORs	Or7、Or10、Or88	宿主偏好性	[28]
	OBPs	Obp37、39	气味分子转导	[37]
埃及伊蚊	ORs	Or4	宿主偏好性	[38]
	IRs	Ir8a	乳酸探测	[32]
致倦库蚊	ORs	Or114、117	吸血行为	[39]
	ORs	Or136	驱避剂DEET与茉莉酸甲酯探测	[29]
	OBPs	Obp1	产卵地选择	[40]
	OBPs	Obp5	产卵信息素	[41]

物种	性别决定系统（雌性/雄性）	雄性决定因子	参考文献
冈比亚按蚊	XX/XY	gYG2/Yob^a	[51-52]
斯氏按蚊	XX/XY	Guy1^a	[53-54]
埃及伊蚊	mm/Mm	Nix	[55-56]
白纹伊蚊	mm/Mm	Nix^a	[57-58]
致倦库蚊	mm/Mm	未知	[59]
三带喙库蚊	mm/Mm	未知	[60]
骚扰阿蚊	mm/Mm	未知	[61]

媒介蚊虫的嗅觉发生和性别决定

Olfactory perception and sex determination of vector mosquitoes

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 2

参考文献 81

相关文章 15

编辑推荐

Metrics

本文评价

[1]	张虹, 程功. 人体挥发物对蚊虫行为影响的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(1): 10-14.
[2]	郭红霞, 赵腾, 吴家红, 李春晓. 人皮肤微生物对蚊虫嗅觉行为影响的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(1): 94-98.
[3]	谷真毓, 赵腾, 李春晓. 蚊虫气味结合蛋白和气味受体研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(6): 753-757.
[4]	王洋, 李婷婷, 公茂庆. 蚊虫嗅觉受体研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(5): 647-652.
[5]	周洁, 李春晓, 兰策介, 高剑, 刘钦梅, 孙爱娟, 赵彤言. 淡色库蚊与骚扰库蚊触角嗅觉基因表达分析[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(4): 453-457.
[6]	郭玉燕, 罗雷, 宋璋瑶, 郑学礼. 我国部分地区28种蚊虫的线粒体COⅠ基因序列分析[J]. 中国寄生虫学与寄生虫病杂志, 2017, 35(3): 280-287.
[7]	郭玉燕, 罗雷, 郑学礼. DNA条形码技术在蚊虫分类鉴定中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2017, 35(1): 93-98.
[8]	俞明明1，徐文岳2 *. 昆虫气味受体及其介导的嗅觉信号转导途径[J]. 中国寄生虫学与寄生虫病杂志, 2011, 29(2): 14-147-150,153.
[9]	杨频. 转基因蚊最新研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2011, 29(2): 15-151-153.
[10]	瞿逢伊. 我国蚊虫种质资源现状及其共享利用[J]. 中国寄生虫学与寄生虫病杂志, 2006, 24(增刊): 3-s16.
[11]	朱淮民. 蚊虫采集、保存及标本制作[J]. 中国寄生虫学与寄生虫病杂志, 2006, 24(增刊): 16-s75.
[12]	张昕;刘相萍;闫歌;甄天民;王新国;孙传红;王怀位. 苏云金杆菌以色列亚种晶体蛋白CryIVD基因的克隆及表达产物的效果测定[J]. 中国寄生虫学与寄生虫病杂志, 2002, 20(5): 5-277.
[13]	李凤舞;牛春;叶炳辉;诸欣平;陈佩惠. 套式PCR检测蚊体内疟原虫的敏感性与特异性[J]. 中国寄生虫学与寄生虫病杂志, 1998, 16(3): 164-167.
[14]	包怀恩,苏晓庆,郎书源,邹复珍. 大链壶菌对蚊幼虫作用的组织学观察[J]. 中国寄生虫学与寄生虫病杂志, 1996, 14(4): 303-306.
[15]	袁本聪. 云南省无血吸虫病有钉螺地区的情况[J]. 中国寄生虫学与寄生虫病杂志, 1993, 11(3): 236-236.