华支睾吸虫致胆管癌发生发展的研究进展

doi:10.12140/j.issn.1000-7423.2020.02.019

中国寄生虫学与寄生虫病杂志 ›› 2020, Vol. 38 ›› Issue (2): 250-254.doi: 10.12140/j.issn.1000-7423.2020.02.019

华支睾吸虫致胆管癌发生发展的研究进展

李潇¹, 王江畅², 管磊², 顾畦², 董纪泽², 吴琛耘², 严敏¹, 王兆军²^,³^,^*()

1 昆明医科大学基础医学院病原生物学与免疫学系,昆明 650500
2 上海交通大学医学院病原生物学与免疫学系,上海 200025
3 上海交通大学医学院-国家热带病研究中心全球健康学院,上海 200025

收稿日期:2019-07-29 出版日期:2020-04-30 发布日期:2020-05-11
通讯作者: 王兆军
作者简介:李潇（1995-）,女,硕士研究生,主要从事感染与免疫方向的研究。E-mail： lixiaoo1995@163.com
基金资助:
上海市自然科学基金(19ZR1428500);国家自然科学基金面上项目(81971486)

Advances in the pathogenesis of cholangiocarcinoma caused by Clonorchis sinensis

Xiao LI¹, Jiang-chang WANG², Lei GUAN², Qi GU², Ji-ze DONG², Chen-yun WU², Min YAN¹, Zhao-jun WANG²^,³^,^*()

1 Department of Microbiology and Immunology, Kunming Medical University, Kunming 650500, China
2 Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
3 School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2019-07-29 Online:2020-04-30 Published:2020-05-11
Contact: Zhao-jun WANG
Supported by:
Supported by the Natural Science Foundation of Shanghai(19ZR1428500);the National Natural Science Foundation of China(81971486)

摘要/Abstract

摘要：

华支睾吸虫是一种食源性寄生虫,其感染可导致宿主肝胆管病变,甚至诱发胆管癌。本文结合近年来的相关研究,从虫体的毒性作用、宿主的异常免疫反应以及其他病原体共感染等方面对华支睾吸虫导致胆管癌发生发展的致病机制进行阐述。

关键词: 华支睾吸虫, 胆管癌, 排泄分泌物, 免疫因素

Abstract:

Clonorchis sinensis is a food-borne parasite that can cause hepatobiliary lesions and even cholangiocarcinoma. This review summarizes recent progress in the pathogenesis of cholangiocarcinoma caused by C. sinensis, from perspectives of toxicity of worms, abnormal immune responses of hosts and co-infection with other pathogens.

Key words: Clonorchis sinensis, Cholangiocarcinoma, Excretory/secretory products, Immune factors

中图分类号:

R383.22

李潇, 王江畅, 管磊, 顾畦, 董纪泽, 吴琛耘, 严敏, 王兆军. 华支睾吸虫致胆管癌发生发展的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(2): 250-254.

Xiao LI, Jiang-chang WANG, Lei GUAN, Qi GU, Ji-ze DONG, Chen-yun WU, Min YAN, Zhao-jun WANG. Advances in the pathogenesis of cholangiocarcinoma caused by Clonorchis sinensis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2020, 38(2): 250-254.

图/表 1

参考文献 40

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华支睾吸虫致胆管癌发生发展的研究进展

Advances in the pathogenesis of cholangiocarcinoma caused by Clonorchis sinensis

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