IL-33/ST2信号通路在感染性疾病中的研究进展

中国寄生虫学与寄生虫病杂志

IL-33/ST2信号通路在感染性疾病中的研究进展

姜纯杰，关飞，雷家慧*

华中科技大学同济医学院基础医学院，武汉 430030

出版日期:2018-06-30 发布日期:2018-07-02

Research progress on the role of IL-33/ST2 axis in infectious diseases

JIANG Chun-jie, GUAN Fei, LEI Jia-hui*

School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Online:2018-06-30 Published:2018-07-02

摘要/Abstract

摘要：

白细胞介素33（IL-33）是2005年新发现的IL-1家族细胞因子。IL-33通过与其受体肿瘤发生抑制蛋白2（ST2）特异性结合发挥生物学作用，这一过程通常被称为IL-33/ST2信号通路。在不同感染性疾病中，IL-33/ST2信号通路因病原体种类、涉及器官、感染阶段（急、慢性）和免疫微环境等不同而发挥不同的作用。本文综述了IL-33/ST2信号通路在细菌、病毒、真菌和寄生虫等所致感染性疾病中的作用。

关键词: 感染性疾病, 白细胞介素33, 肿瘤发生抑制蛋白2

Abstract:

The interleukin-33(IL-33) is a IL-1 family cytokine newly discovered in 2005, and it functions by specifically binding to its receptor suppression of tumorigenicity 2(ST2), forming the IL-33/ST2 axis. The IL-33/ST2 axis plays different roles in different infectious diseases, depending on the type of infectious agents, organ involved, infection stage (acute or chronic), and cellular and cytokine microenvironments. In this review, we focus on recent research progress on diverse roles of the IL-33/ST2 axis in various infectious diseases caused by bacteria, viruses, fungi and parasites.

Key words: Infectious disease, Interleukin-33, ST2

姜纯杰，关飞，雷家慧*. IL-33/ST2信号通路在感染性疾病中的研究进展[J]. 中国寄生虫学与寄生虫病杂志.

JIANG Chun-jie, GUAN Fei, LEI Jia-hui*. Research progress on the role of IL-33/ST2 axis in infectious diseases[J]. Chinese Journal of Parasitology and Parasitic Diseases.