关键词: 缓控释传递系统, 寄生虫, 瘤胃巨丸剂, 长效注射剂, 原位固化植入剂, 微粒, 纳米粒子

Abstract:

Parasitic infections， especially the gastrointestinal and lung nematode infections， are most common in livestock in temperate areas， and it is the major constraints affecting livestock production. In grazing season， outdoor activities of animals cause inconvenience to the application of antiparasitic drugs. Therefore， controlled drug delivery systems can prolong the effect time and reduce the difficulty of drug administration. This review summarizes several types of long-term delivery devices and dosage forms including intraruminal devices， long-acting injectables， in-situ forming implants， novel microparticles and nanoparticles. Their advantages and drawbacks are dicussed.

Key words: Controlled drug release, Parasite, Intraruminal device, Long-acting injectable, In situ forming implant, Microparticle, Nanoparticle