中国寄生虫学与寄生虫病杂志 ›› 2010, Vol. 28 ›› Issue (1): 16-71.

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宿主树突状细胞与血吸虫感染

李小红, 汤林华*, 曹建平   

  1. 中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病与媒介生物学重点实验室,世界卫生组织疟疾、血吸虫病和丝虫病合作中心,上海 200025
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-02-28 发布日期:2010-02-28

Dendritic Cell Function in Response to Schistosome Infection

LI Xiao-hong,TANG Lin-hua*,CAO Jian-ping   

  1. National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention;Laboratory of Parasite and Vector Biology,MOH;WHO Collaborating Centre for Malaria,Schistosomiasis and Filariasis,Shanghai 200025,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-02-28 Published:2010-02-28

摘要: 树突状细胞是目前已知的功能最强的一类抗原呈递细胞,是连接固有免疫和获得性免疫的桥梁,近年来研究进展显著。在血吸虫病领域的研究发现,宿主树突状细胞经血吸虫感染刺激后的表型与常规成熟的表型不同。研究血吸虫感染与宿主树突状细胞之间的相互作用将有助于丰富该类细胞的生物学研究,也将为血吸虫病的疫苗和治疗研究提供支撑。

关键词: 树突状细胞, 血吸虫

Abstract: Dendritic cells (DC) are uniquely specialised for both antigen acquisition and presentation, linking innate and adaptive immunity. Great progress has been made in DC biology and function recently. In the field of schistosomiasis,studies have revealed that a DC phenotype is quite distinct to that of conventional activation. Understanding the interaction between schistosomes and DC is therefore not only addressing fundamental questions of DC biology and immunity to multicellular parasites but also opening the way to therapeutic manipulation of the immune system.

Key words: Dendritic cell, Schistosome