关键词: 卡氏肺孢子虫肺炎（PCP）, 补骨脂, 鸦胆子, IL-2, NK细胞

Abstract: SD rat model of PCP was established by subcutaneous injection with dexamethasone. The treatment groups received Fructus psoraleae（FP， 10.0 mg/kg）， Brucea javanica（BJ， 1.2 mg/kg） and a mixture of the two Chinese herbs（FP 5mg/kg， BJ 0.6 mg/kg） respectively. By means of detecting the level of IL-2 in sera and NK cells in spleens， the effect of FP and BJ on the level of IL-2 and NK cells in rats with Pneumocystis carinii pneumonia （PCP） was observed， with SMZco treatment group （TMP 50 mg/kg， SMZ 250 mg/kg） and groups of infected and normal rats as controls. Compared with the infected group， the level of IL-2（526.1±5.5） pg/ml and NK cells（27.1%±0.8%） significantly increased in the FP group（P<0.01）， followed by the FP/BJ combination group ［（314.7±6.7) pg/ml， 22.9%±0.9%）（P<0.05）］， and BJ group ［（285.4±6.1) pg/ml， 20.7%±1.0%）（P<0.05）］. Chinese herbs Fructus psoraleae and Brucea javanica show an immune regulatory action on the PCP rats.

Key words: Pneumocystis carinii pneumonia, Fructus psoraleae, Brucea javanica, IL-2, NK cell