中国寄生虫学与寄生虫病杂志 ›› 2007, Vol. 25 ›› Issue (5): 13-414.

• 实验研究 • 上一篇    下一篇

氯代水杨胺灭螺效果的实验研究

金伟1;杜金奎1;元艺2;魏凤华2;刘伟1;王辉1;李桂玲1;徐兴建2   

  1. 1 华中科技大学,武汉 430030;2 湖北省疾病预防控制中 心血吸虫病防治研究所,武汉 430079
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-10-30 发布日期:2007-10-30
  • 通讯作者: 李桂玲

Study on Molluscicidal Effect of Chlorosalicylicamide

JIN Wei1;DU Jin-kui1;YUAN Yi2;WEI Feng-hua2; LIU Wei1;
WANG Hui1;LI Gui-ling 1;XU Xing-jian2
  

  1. 1 Department of Chemistry and Chemical Industry, Huazhong University of Science and Technology, Wuhan 430030,China; 2 Institute of Schistosomiasis Control, Hubei Provincial Center for Disease Control and Prevention,Wuhan 430079,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-10-30 Published:2007-10-30
  • Contact: LI Gui-ling

摘要: 目的 观察氯代水杨胺的灭螺效果和对鱼苗的毒性。 方法 配制不同浓度的氯代水杨胺,用浸泡法、喷洒法观察不同浓度和不同作用时间的灭螺效果,并进行鱼苗毒性实验。氯硝柳胺乙醇胺盐作对照。 结果 氯代水杨胺的浓度为0.25和0.5 mg/L,浸泡48 h,钉螺死亡率分别为97.8%、100%,半数有效致死浓度(LC50)为0.067 4 mg/L;氯硝柳胺乙醇胺盐浓度为0.25和0.5 mg/L,浸泡48 h,钉螺死亡率分别为22.2%、66.7%,LC50为0.3976 mg/L。药物浓度为0.4 mg/L喷洒1、3、7和15 d,氯代水杨胺的灭螺率分别为90%、100%、100%和100%;氯硝柳胺乙醇胺盐的灭螺率分别为60%、70%、70%和50%。0.25 mg/L浸泡48 h,氯代水杨胺和氯硝柳胺乙醇胺盐刺激钉螺离水上爬率分别为32.2%和46.7%。0.4 mg/L药物作用72 h,氯代水杨胺和氯硝柳胺乙醇胺盐的鱼苗死亡率分别为50.0%和100%。 结论 氯代水杨胺有灭钉螺作用,对鱼苗毒性比氯硝柳胺乙醇胺盐略低,并有抑制钉螺上爬作用。

关键词: 氯代水杨胺, 氯硝柳胺乙醇胺盐, 钉螺, 灭螺药物

Abstract: Objective To observe the molluscicidal effect of chlorosalicylicamide on Oncomelania hupensis and toxicity on fishes. Methods Different concentrations of chlorosalicylicamide were prepared, and immersion and spraying methods were used to test its molluscicidal effect and toxicity to fishes. Niclosamide ethanolamine salt was used as control. Results Under water temperature of 28 ℃ with the dose of chlorosalicylicamide at 0.25 mg/L and 0.4 mg/L, the mortality rate of snails by immersion was 97.8% and 100% respectively after 48 h, and the LC50 was 0.067 4 mg/L. While for niclosamide at the same doses, the mortality rate of snails was 22.2% and 66.7% respectively, and the LC50 was 0.397 6 mg/L. With the concentration of 0.4 mg/L for 72 h, the fish death rate in chlorosalicylicamide and niclosamide was 50.0% and 100% respectively. Conclusion Chlorosalicylicamide shows a molluscicidal effect on Oncomelania snails and a lower toxicity to fishes than that of niclosamide.

Key words: Chlorosalicylicamide, Niclosamide, Oncomelania hupensis, Molluscicide