十二烷基苯磺酸钠治疗蠕形螨病的实验和临床研究

中国寄生虫学与寄生虫病杂志 ›› 2005, Vol. 23 ›› Issue (4): 8-224.

十二烷基苯磺酸钠治疗蠕形螨病的实验和临床研究

臧运书¹,吴大军²,宋建波²

1 青岛大学医学院附属医院皮肤科,青岛 266003;2 即墨市人民医院皮肤科,即墨 266200

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2005-08-30 发布日期:2005-08-30

Experimental and Clinical Studies on the Effect of Sodium Dodecylbenzene Sulfonate in in vitro Killing Demodex and in Treating Demodicidosis

ZANG Yun-shu¹，WU Da-jun²，SONG Jian-bo²

Department of Dermatology,Affiliated Hospital of Medical College of Qingdao University,Qingdao 266003,China

Received:1900-01-01 Revised:1900-01-01 Online:2005-08-30 Published:2005-08-30

摘要/Abstract

摘要： 目的观察十二烷基苯磺酸钠(SDBS)体外杀螨效果、治疗蠕形螨病的疗效及其安全性。方法①观察1%及2%SDBS体外杀螨效果。②临床观察2%SDBS软膏和2%甲硝唑软膏对蠕形螨病的疗效。确诊面部蠕形螨病患者62例,随机分为试验组和对照组(各31例),每天早、晚各1次将药物涂于患处,连续用药8周。用药前、后计数面部炎性损害、蠕形螨感染度及红斑评分,以评价疗效。③治疗8周后随访两个月,观察疗效及副作用。结果①体外杀螨试验,用药5 h,2%SDBS组的螨全部死亡,与2%甲硝唑组(69.4%)及花生油组(9.1%)比较,其差异均有显著性(P<0.05)。2%SDBS杀灭毛囊与皮脂蠕形螨效果,两者间差异无显著性(P>0.05)。②临床试验结果表明,炎性损害、蠕形螨感染度及红斑评分,2%SDBS组治疗前、后差异具有显著性(P<0.05)。治疗后,2%SDBS组(87.1%)与2%甲硝唑组(65.5%)有效率,差异具有显著性(P<0.05)。随访结果无变化。③副作用:2%SDBS治疗皮脂蠕形螨病,3例局部有轻微烧灼感。结论SDBS具有体外杀螨作用,治疗蠕形螨病安全有效。

关键词: 蠕形螨病, 十二烷基苯磺酸钠, 治疗结果

Abstract: Objective To observe the effect of sodium dodecylbenzene sulfonate (SDBS) in killing Demodex in vitro and in the treatment of demodicidosis. Methods ① The experiment of in vitro killing Demodex with 1% and 2% SDBS was conducted. ② A clinical trial was carried out to evaluate the therapeutic effect in the treatment of demodicidosis with 2% SDBS and 2% metronidazole emulsion. Patients with demodicidosis were randomly divided into trial and control groups (31 cases each). They were treated with 2% SDBS ointment and 2% metronidazole ointment twice a day in the early morning and evening respectively for eight weeks consecutively. Inflammatory lesions of face, Demodex infestation and scores of erythema were measured to evaluate the effect before and after treatment. ③ Follow-up was carried out for two months to evaluate the effect and side-effects after 8 weeks' treatment. Results ① 2% SDBS killed all Demodex in vitro after 5h, there was significant difference between the 2% SDBS and 2% metronidazole (69.4%), or between SDBS and peanut oil (9^1%)(P<0.05). There was no significant difference in killing Demodex folliculorum and Demodex brevis with 2% SDBS. ② Clinical observation showed that there was a significant difference in facial inflammatory lesions, Demodex infestation and scores of erythema before and after treatment with 2% SDBS(P<0.05). The effective rate was 87^1%, 65^5% in 2% SDBS group and 2% metronidazole group respectively, with a significant difference between the two groups (P<0.05). Follow-up showed same results. ③ A slight burning sensation was the only side-effect in 3 cases with 2% SDBS ointment. Conclusion Sodium dodecylbenzene sulfonate has the effect of in vitro killing Demodex and is highly effective in the treatment of demodicidosis.

Key words: Demodicidosis, Sodium dodecylbenzene sulfonate, Treatment outcame

臧运书;吴大军;宋建波. 十二烷基苯磺酸钠治疗蠕形螨病的实验和临床研究[J]. 中国寄生虫学与寄生虫病杂志, 2005, 23(4): 8-224.

ZANGYun-shu;WUDa-jun;SONGJian-bo. Experimental and Clinical Studies on the Effect of Sodium Dodecylbenzene Sulfonate in in vitro Killing Demodex and in Treating Demodicidosis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2005, 23(4): 8-224.

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