关键词: 日本血吸虫, 吡喹酮, 酶活力, 对硝基苯胺, 谷氨酰, 转肽酶, 氨基酸, 寄生虫病研究所, 中国预防医学科学院, 体内试验

Abstract: γ-glutamyltranspeptidase(γ-GTP) was found to exist in the tegument of S. japonicum, as revealed by Oaks method. Praziquantel at the concentration of 1 × 10-2 mM could inhibit in vitro the tegumental γ-GTP of male worm by 23%. By using intact worms, it was found that the activity of γ-GTP was higher than that of the tegument. The in vitro inhibitory effect of praziquantel on γ-GTP of female schistosomes was higher than that of the male worms. The authors have only measured the in vivo enzymatic activity of male worms, and the significant inhibitory effect of γ-GTP by praziquantel was found. At the same dosage, praziquantel did not show any inhibitory effect on the γ-GTP of the host kidney.