间日疟原虫入侵网织红细胞相关蛋白的研究进展

doi:10.12140/j.issn.1000-7423.2022.03.018

中国寄生虫学与寄生虫病杂志 ›› 2022, Vol. 40 ›› Issue (3): 396-401.doi: 10.12140/j.issn.1000-7423.2022.03.018

间日疟原虫入侵网织红细胞相关蛋白的研究进展

石天琪(), 陈军虎()

中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）,世界卫生组织热带病合作中心,科技部国家级热带病国际联合研究中心,卫生部寄生虫病原与媒介生物学重点实验室,上海 200025

收稿日期:2021-12-27 修回日期:2022-03-13 出版日期:2022-06-30 发布日期:2022-07-06
通讯作者: 陈军虎
作者简介:石天琪（1997-）,女,硕士研究生,从事寄生虫病防治研究。E-mail： 761561107@qq.com
基金资助:
上海市公共卫生体系建设三年行动计划(2020-2022)重点学科(GWV-10.1-XK13);上海市国际科技合作基金(18490741100)

Research progress on reticulocyte binding proteins associated with Plasmodium vivax invasion of reticulocytes

SHI Tian-qi(), CHEN Jun-hu()

National Institute of Plarasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China

Received:2021-12-27 Revised:2022-03-13 Online:2022-06-30 Published:2022-07-06
Contact: CHEN Jun-hu
Supported by:
Fifth Round of Three-Year Public Health Action Plan of Shanghai(GWV-10.1-XK13);Project of Shanghai Science and Technology Commission(18490741100)

摘要/Abstract

摘要：

间日疟原虫是世界上分布最广泛的疟原虫,也是造成非洲以外地区人群感染疟疾的主要原因。间日疟原虫优先入侵网织红细胞,呈现高度的种特异性。间日疟原虫网织红细胞结合蛋白（PvRBP）家族作为入侵配体,介导了间日疟原虫入侵网织红细胞的新途径,是重要的免疫靶点。其中PvRBP2b与转铁蛋白受体1（TfR1）,PvRBP2a与CD98的相互作用对间日疟原虫入侵网织红细胞至关重要。Pvrbp家族具有高度多态性并且可产生免疫逃避,能够增加间日疟入侵的效率和致病的严重程度。随着对间日疟原虫入侵分子机制研究的日益加深,研究产生高滴度抗体的疟疾疫苗将成为有效预防和控制疟疾的关键方法。本文就网织红细胞在间日疟原虫感染中的作用,以及PvRBP家族在人群产生免疫应答的研究进展作一综述。

关键词: 间日疟原虫, 入侵, 网织红细胞结合蛋白, 自然获得性免疫

Abstract:

Plasmodium vivax is the most geographically widespread malaria parasite that causes most malaria infection cases outside the most malarious continent, sub-Saharan Africa. P. vivax preferentially invades reticulocytes, with a high species specificity. P. vivax reticulocyte binding protein (PvRBP) family has been implicated in roles in reticulocyte invasion and severity of P. vivax infections. The members of PvRBP family act as invasion ligands that mediate new pathways for the parasites to invade reticulocytes, and therefore, are considered important immune targets. Importantly, PvRBP2a-CD98 and PvRBP2b-TfR1 have been identified as two major ligand-receptor pairs implicated in the invasion of reticulocytes by P. vivax. The Pvrbp family is highly polymorphic and can generate immune evasion, which can increase the efficiency of vivax malaria invasion and the severity of the disease. With the advances in research on the molecular mechanisms of P. vivax invasion, insights have been provided on members of this protein family as promising antimalarial vaccine candidates, able to generate high titer antibodies for effective prevention and control of vivax malaria. This review summarizes the role of reticulocytes in P. vivax infection and the function of the PvRBP proteins family as immune targets in the human population.

Key words: Plasmodium vivax, Reticulocyte binding protein, Invasion, Natural acquired immunity

中图分类号:

R382.311

石天琪, 陈军虎. 间日疟原虫入侵网织红细胞相关蛋白的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(3): 396-401.

SHI Tian-qi, CHEN Jun-hu. Research progress on reticulocyte binding proteins associated with Plasmodium vivax invasion of reticulocytes[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2022, 40(3): 396-401.

图/表 1

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间日疟原虫入侵网织红细胞相关蛋白的研究进展

Research progress on reticulocyte binding proteins associated with Plasmodium vivax invasion of reticulocytes

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