中国寄生虫学与寄生虫病杂志

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过继转移在蠕虫调控过敏性和自身免疫性疾病的研究进展

丁忆晗1,周瑞2,杨小迪1*,张莉莉1   

  1. 1蚌埠医学院病原生物学教研室,安徽省感染与免疫重点实验室,蚌埠 233030;2蚌埠医学院第一附属医院儿科,蚌埠 233030
  • 出版日期:2015-08-30 发布日期:2015-09-10

The Role of Adoptive Transfer of Immune Cells in Helminth-induced Regulation of Allergy and Autoimmune Diseases

DING Yi-han1,ZHOU rui2,YANG Xiao-di1*,ZHANG Li-li1   

  1. 1 Department of Microbiology and Parasitology,Anhui Key Laboratory of Infection and Immunity,Bengbu Medical College,Bengbu 233030,China;2 Department of Pediatrics,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China
  • Online:2015-08-30 Published:2015-09-10

摘要:

寄生蠕虫或其衍生物可通过诱导免疫细胞的活化,释放调节性细胞因子,从而抑制过敏性及自身免疫性疾病。目前大量的动物实验表明过继回输活化的淋巴细胞对免疫失调性疾病具有保护作用,体现出潜在的临床应用价值。本文对过继转移在蠕虫调控过敏性和自身免疫性疾病方面的进展进行综述。

关键词: 蠕虫, 过继转移, 过敏性和自身免疫性疾病

Abstract:

Parasitic worms(helminth) or their derivates can inhibit allergy and autoimmune diseases by inducing the activation of immune cells and thus the release of regulatory factors. A large number of animal experiments have shown that adoptive transfer of lymphocytes can protect against immune deregulation and have potential clinical applications. In this review, we discuss the research progress on the role of adoptive transfer of immune cells in worm-induced regulation of allergy and autoimmune diseases.

Key words:  , Helminth;Adoptive transfer;Allergy and autoimmune diseases