中国寄生虫学与寄生虫病杂志 ›› 2000, Vol. 18 ›› Issue (3): 15-175.

• 实验研究 • 上一篇    下一篇

日本血吸虫感染对小鼠雄性激素水平的影响(英文)

贺宏斌1,Nobuo Ohta2,Hitoshi Kawaguchi 2
  

  1. 湖南省寄生虫病防治研究所!岳阳414000;DepartmentofMedicalZoology!NagoyaCityUniversityMedicalSchool;Nagoya;Japan;DepartmentofMedicalZoology!NagoyaCityUniversityMedicalSchool;Nagoya;Japan
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2000-06-30 发布日期:2000-06-30

EFFECT OF SCHISTOSOMA JAPONICUM INFECTION ON SERUM TESTOSTERONE LEVELS IN MICE

HE Hong bin 1;Nobuo Ohta 2;Hitoshi Kawaguchi 2   

  1. 1 Hunan Institute of Parasitic Diseases;Yueyang 414000 WHO Collaborating Center for Research and Control on Schistosomiasis in Lake Regions; 2 Department of Medical Zoology;Nagoya City University Medical School,Nagoya,Japan
  • Received:1900-01-01 Revised:1900-01-01 Online:2000-06-30 Published:2000-06-30

摘要:   [目的 ]研究日本血吸虫感染对 C5 7BL/ 6小鼠雄性激素的影响。[方法 ]应用放射免疫测定法检测实验感染日本血吸虫动物血清中雄性激素睾酮的水平。 [结果 ]感染日本血吸虫 45 d小鼠血清中睾酮的水平明显低于对照组。 [结论 ]日本血吸虫感染可导致小鼠宿主雄性激素睾酮水平显著降低。

关键词: 日本血吸虫, 雄性激素, 小鼠, 放射免疫

Abstract:  Objective] To determine the effect of Schistosoma japonicum infection on the testoterone level in the sera from male C57BL/6 mice. [Methods] Radioimmunoassay was used to examine testosterone levels in sera of 9 male mice experimentally infected with Schistosoma japonicum . [Results] The serum testosterone levels reduced significantly in all experimentally infected animals 45 days after infection, as compared with the uninfected controls. [Conclusion] Infection with Schistosoma japonicum decreases testosterone levels in the mouse host.

Key words: Schistosoma japonicum, testosterone, mouse, radioimmunoassay.