中国寄生虫学与寄生虫病杂志 ›› 2022, Vol. 40 ›› Issue (6): 780-785.doi: 10.12140/j.issn.1000-7423.2022.06.014

• 综述 • 上一篇    下一篇

细胞焦亡在人体寄生虫病中的研究进展

乜茹1,2,3(), 李文登1,2, 冶赓博1,2,3, 尹凤娇1,2,3, 庞明泉1,2, 王志鑫1,2, 樊海宁1,2,*()   

  1. 1.青海大学附属医院肝胆胰外科,西宁 810001
    2.青海省包虫病研究重点实验室,西宁810001
    3.青海大学研究生院,西宁 810001
  • 收稿日期:2022-05-29 修回日期:2022-08-29 出版日期:2022-12-30 发布日期:2022-12-26
  • 通讯作者: 樊海宁
  • 作者简介:乜茹(1987-),女,硕士研究生,从事棘球蚴免疫研究工作。E-mail:zzzsruru@163.com
  • 基金资助:
    青海省科技厅重点实验室项目(2020-ZJ-Y01);青海大学附属医院中青年科研基金一般项目(ASRF-2019-YB-04)

Research progress on the role of pyroptosis in human parasitic diseases

NIE Ru1,2,3(), LI Wen-deng1,2, YE Geng-bo1,2,3, YIN Feng-jiao1,2,3, PANG Ming-quan1,2, WANG Zhi-xin1,2, FAN Hai-ning1,2,*()   

  1. 1. Department of Hepatopancreatobiliary Surgery, the Affiliated Hospital of Qinghai University, Xining 810001, China
    2. Qinghai Province Key Laboratory of Hydatid Disease Research, Xining 810001, China
    3. Graduate School of Qinghai University, Xining 810001, China
  • Received:2022-05-29 Revised:2022-08-29 Online:2022-12-30 Published:2022-12-26
  • Contact: FAN Hai-ning
  • Supported by:
    Key Laboratory Project of Qinghai Provincial Science and Technology Department(2020-ZJ-Y01);Qinghai University Affiliated Hospital, General Project of Young and Middle-aged Research Fund(ASRF-2019-YB-04)

摘要:

细胞焦亡是近年发现的一种依赖半胱氨酸天冬氨酸蛋白酶(caspase)的新型细胞死亡方式,活化后的caspase以剪切消皮素(GSDM)蛋白家族为途径,使细胞膜发生破裂,同时释放炎性细胞因子及其内容物,最终导致细胞死亡,其发生、形态学特征及调控机制与凋亡、坏死、自噬、铁死亡等细胞死亡方式有明显不同。细胞焦亡信号通路可分为经典途径、非经典途径和其他途径。目前大量研究证实,细胞焦亡参与寄生虫病的发展历程。本文就细胞焦亡的定义、不同途径机制及其在多种人体寄生虫病中发挥的作用作一综述,以期为开拓细胞焦亡与寄生虫疾病之间的作用提供依据。

关键词: 细胞焦亡, 消皮素, 半胱氨酸天冬氨酸蛋白酶, Nod样受体蛋白3, 人体寄生虫病

Abstract:

Pyroptosis is a new type of death mode found in recent years, which depends on caspase. Activated caspase breaks the cell membrane by cutting gasdermin protein, and at the same time, it releases pro-inflammatory cytokines and their contents, eventually leading to cell death. Its occurrence, morphological characteristics and regulatory mechanism are different from cell death modes such as apoptosis, necrosis, autophagy and iron death. Pyroptosis signal pathways include classical pathway, non-classical pathway and other pathways. At present, many studies have confirmed that pyroptosis is involved in the development of parasitic diseases. This article reviews the definition of pyroptosis, different pathways and mechanisms, and their roles in various Human parasitic diseases, hoping to provide a basis for developing the research between pyroptosis and parasitic diseases.

Key words: Pyroptosis, Gasdermin protein, Caspase, Nod-like receptor protein 3, Human parasitic disease

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