中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (3): 393-402.doi: 10.12140/j.issn.1000-7423.2021.03.016

• 综述 • 上一篇    下一篇

青蒿素及其衍生物治疗疟疾的研究进展

杨博(), 孙毅凡, 雷瑶, 程洋*()   

  1. 江南大学无锡医学院病原感染与免疫研究室,无锡 214000
  • 收稿日期:2020-08-20 修回日期:2020-09-25 出版日期:2021-06-30 发布日期:2021-07-05
  • 通讯作者: 程洋
  • 作者简介:杨博(1996-),女,硕士研究生,从事病原感染与免疫研究。E-mail: 15546656573@163.com
  • 基金资助:
    国家自然科学基金(81871681);江南大学研究生科研与实践创新计划项目(1282050205198168)

Research progress on the treatment of malaria with artemisinin and its derivatives

YANG Bo(), SUN Yi-fan, LEI Yao, CHENG Yang*()   

  1. Laboratory of Pathogen Infection and Immunity, Wuxi School of Medicine, Jiangnan University, Wuxi 214000, China
  • Received:2020-08-20 Revised:2020-09-25 Online:2021-06-30 Published:2021-07-05
  • Contact: CHENG Yang
  • Supported by:
    National Natural Science Foundation of China(81871681);Research and Practice Innovation Program for University-level postgraduates of Jiangnan University(1282050205198168)

摘要:

青蒿素是一种安全性良好的抗疟药物,以青蒿素为基础的联合用药已被世界卫生组织推荐为治疗恶性疟的一线方法。然而,青蒿素在治疗疟疾的过程中已产生耐药性,并已逐渐成为疟疾控制的主要威胁。青蒿素类药物以其速效、低毒等特点备受关注。近年来,青蒿素及其衍生物的研究和临床应用正在不断开展与深入,本文对近年来青蒿素类药物的抗疟机制、耐药现象及机制、临床应用等方面的研究进展进行了综述,以期对青蒿素及其衍生物的进一步研究和应用提供有价值的参考。

关键词: 青蒿素, 青蒿素类衍生物, 青蒿素耐药性, 疟疾

Abstract:

Artemisinin is a safe antimalarial drug. Artemisinin-based drug combinations have been recommended by the World Health Organization as the first-line treatment for falciparum malaria. However, artemisinin resistance is emerging in the treatment of malaria, and has gradually become a major threat to malaria control. Artemisinin drugs have attracted much attention due to the quick effect and low toxicity. In recent years, research and clinical application of artemisinin and its derivatives have been continuously carried out in depth. This paper reviews the antimalarial mechanism, drug resistance phenomenon and mechanism and clinical application of artemisinin drugs, in order to provide valuable reference of further research and application of artemisinin and its derivatives.

Key words: Artemisinin, Artemisinin derivatives, Artemisinin resistance, Malaria

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