Nod样受体蛋白3炎症小体在寄生虫病中的研究进展

doi:10.12140/j.issn.1000-7423.2020.03.021

摘要/Abstract

摘要：

炎症小体作为固有免疫系统的感受器,活化后可以参与抵抗病原生物体的应激反应。本文总结归纳了Nod样受体蛋白3（NLRP3）炎症小体的基本结构、功能及其在疟疾、溶组织内阿米巴病、克氏锥虫病、利什曼原虫病、血吸虫病、阴道毛滴虫病中的相关研究,旨在分析NLRP3炎症小体在寄生虫病中的作用及机制,为干预与治疗手段优化提供思路。

关键词: 寄生虫病, Nod样受体蛋白3炎症小体, 炎症, 免疫反应

Abstract:

Inflammatory corpuscles are receptors of the innate immune system and participate in the stress responses against pathogenic organisms after activated. This review summarizes the basic structure and functions of Nod-like receptor protein 3 (NLRP3) inflammasome as well as the related researches on malaria, amoebic disease, trypanosomiasis, leishmaniasis, schistosomiasis, and vaginal trichomoniasis, aiming to analyze the role and mechanism of NLRP3 inflammasome in parasitic diseases and provide ideas for better interventions and treatment.

Key words: Parasitic disease, Nod-like receptor protein 3 inflammasome, Inflammation, Immune response

中图分类号:

陈蔡松, 张耀刚, 王志鑫, 樊海宁. Nod样受体蛋白3炎症小体在寄生虫病中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(3): 390-394.

CHEN Cai-song, ZHANG Yao-gang, WANG Zhi-xin, FAN Hai-ning. Advances in research on Nod-like receptor protein 3 inflammasome in parasitic diseases[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2020, 38(3): 390-394.

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