免疫检查点分子调控在疟原虫感染与免疫中的研究进展

doi:10.12140/j.issn.1000-7423.2019.04.018

摘要/Abstract

摘要：

疟疾是严重威胁人类健康的头号虫媒传染病。宿主促炎和抑炎反应需要精细调控,以达到在快速清除病原体的同时避免免疫病理损伤的目的。近年来免疫检查点分子（ICM）在抗肿瘤、抗自身免疫性疾病等领域取得了突破性进展,给疟疾抗感染免疫研究,包括疟疾慢性感染和重症疟疾的免疫辅助治疗带来了新的启示。研究表明,在疟原虫慢性感染过程中,阻断ICM信号有助于恢复宿主免疫应答,加速清除疟原虫;在疟原虫急性感染导致的重症疟疾中,适度强化ICM信号,可降低宿主免疫应答,有助于缓解宿主体内免疫病理损伤。本文就ICM调控在不同原虫虫感染中的作用做一简要综述。

关键词: 疟疾, 脑型疟, 免疫检查点分子, 免疫辅助治疗

Abstract:

Malaria is still a life-threatening infectious disease transmitted by mosquito worldwide. It is necessary for host to maintain a delicate balance between pro-and anti-inflammatory immune responses to efficiently eliminate pathogens without inducing immunopathology. In recent years, breakthroughs in immune checkpoint molecules involved in anti-tumor and anti-autoimmune diseases have brought new enlightenment to the anti-malaria immunotherapy in chronic and severe infections. Studies have shown that blocking the immune checkpoint signaling in the chronic malaria infections could restore host immune response and accelerate the elimination of Plasmodium infection. In severe malaria caused by the acute infection of Plasmodium, moderately enhancing the signal of immune checkpoint molecules could reduce the immune response and alleviate the immunopathology caused by Plasmodium infection. This paper provides a brief review of the current progress in immune checkpoint molecules in Plasmodium infection and immunity.

Key words: Malaria, Cerebral malaria, Immune checkpoint molecules, Adjunctive immunotherapy

中图分类号:

R531.3

王军, 沈燕, 李悦, 赵亚. 免疫检查点分子调控在疟原虫感染与免疫中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(4): 472-480.

Jun WANG, Yan SHEN, Yue LI, Ya ZHAO. Recent progress in immune checkpoint molecules in Plasmodium infection and immunity[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2019, 37(4): 472-480.

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