作者简介：刘欣（1992-）,女,硕士研究生,从事寄生虫病研究。E-mail：
收稿日期: 2018-08-29
网络出版日期: 2019-05-13
基金资助
国家自然科学基金（No. 30901247）
Effects of soluble egg antigens on hepatic stellate cells in the progression of schistosomiasis-associated liver fibrosis
Received date: 2018-08-29
Online published: 2019-05-13
Supported by
Supported by the National Natural Science Foundation of China(No. 30901247)
刘欣 , 齐永芬 , 鱼艳荣 . 血吸虫病肝纤维化中可溶性虫卵抗原对肝星状细胞的作用[J]. 中国寄生虫学与寄生虫病杂志, 2019 , 37(2) : 218 -222 . DOI: 10.12140/j.issn.1000-7423.2019.02.018
Schistosomiasis is a zoonotic parasitic disease worldwide caused by the infections of Schistosoma haematobium, S. mansoni and S. japonicum. The schistosomiasis endemic in China is only caused by S. japonicum infection that results in the deposition of eggs in the liver and causes the egg granuloma and eventually the liver fibrosis. The soluble egg antigens secreted by the miracidium induce host strong immune responses that contribute to the egg granuloma and liver fibrosis. Hepatic stellate cells are the central part of liver fibrosis. The regulation of soluble egg antigens on hepatic stellate cells plays important roles in the development of the fibrosis. This article reviews the research progress in the roles of soluble egg antigens on hepatic stellate cells in the progression of schistosomiasis-associated liver fibrosis.
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