收稿日期: 2024-06-06
修回日期: 2024-08-04
网络出版日期: 2025-02-26
基金资助
国家重点研发计划(2021YFC2300800);国家重点研发计划(2021YFC2300801);广东省自然科学基金(2022A1515012560);广东省自然科学基金(2023A1515010955)
Research progress on the mechanism of Clonorchis sinensis miRNAs in the initiation and progression of cholangiocarcinoma
Received date: 2024-06-06
Revised date: 2024-08-04
Online published: 2025-02-26
Supported by
National Key Research and Development Program of China(2021YFC2300800);National Key Research and Development Program of China(2021YFC2300801);Guangdong Natural Science Foundation(2022A1515012560);Guangdong Natural Science Foundation(2023A1515010955)
武奥迅 , 钟籽丰 , 徐安远 , 潘筱雯 , 易雪晴 , 吴银娟 , 李学荣 . 华支睾吸虫miRNA在胆管癌发生发展中作用机制的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025 , 43(2) : 269 -273 . DOI: 10.12140/j.issn.1000-7423.2025.02.018
Clonorchis sinensis is a food-borne parasite. T he adult worms parasitize in the hepatic bile ducts of the host, which could cause pathological changes and induce cholangiocarcinoma. The International Agency for Research on Cancer of the World Health Organization classified C. sinensis as a Class Ⅰ carcinogen in 2009. As a class of endogenous non-coding RNA, micro RNA (miRNA) has a variety of important regulatory roles in cells. MiRNAs secreted by C. sinensis play a relatively important role in the initiation and progression of cholangiocarcinoma. This review summarized the roles of C. sinensis-derived miRNAs in cholangiocarcinoma, aiming to provide novel strategies for preventing and treating cholangiocarcinoma induced by C. sinensis infection.
Key words： Clonorchis sinensis; miRNA; Cholangiocarcinoma; Immune regulation
| [1] | 陈颖丹, 周长海, 朱慧慧, 等. 2015年全国人体重点寄生虫病现状调查分析[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(1): 5-16. |
| Chen YD, Zhou CH, Zhu HH, et al. National survey on the current status of important human parasitic diseases in China in 2015[J]. Chin J Parasitol Parasit Dis, 2020, 38(1): 5-16. (in Chinese) | |
| [2] | Na BK, Pak JH, Hong SJ. Clonorchis sinensis and clonorchiasis[J]. Acta Trop, 2020, 203: 105309. |
| [3] | Bouvard V, Baan R, Straif K, et al. A review of human carcinogens―Part B: Biological agents[J]. Lancet Oncol, 2009, 10(4): 321-322. |
| [4] | Khan SA, Tavolari S, Brandi G. Cholangiocarcinoma: Epidemiology and risk factors[J]. Liver Int, 2019, 39(Suppl 1): 19-31. |
| [5] | Vithayathil M, Khan SA. Current epidemiology of cholangiocarcinoma in western countries[J]. J Hepatol, 2022, 77(6): 1690-1698. |
| [6] | Yoo WG, Sohn WM, Na BK. Current status of Clonorchis sinensis and clonorchiasis in Korea: Epidemiological perspectives integrating the data from human and intermediate hosts[J]. Parasitology, 2022, 149(10): 1296-1305. |
| [7] | Brindley PJ, Bachini M, Ilyas SI, et al. Cholangiocarcinoma[J]. Nat Rev Dis Primers, 2021, 7: 65. |
| [8] | Kim TS, Pak JH, Kim JB, et al. Clonorchis sinensis, an oriental liver fluke, as a human biological agent of cholangiocarcinoma: A brief review[J]. BMB Rep, 2016, 49(11): 590-597. |
| [9] | Yan C, Li XY, Li B, et al. Expression of Toll-like receptor (TLR) 2 and TLR4 in the livers of mice infected by Clonorchis sinensis[J]. J Infect Dev Ctries, 2015, 9(10): 1147-1155. |
| [10] | Zheng SH, Zhu Y, Zhao ZJ, et al. Liver fluke infection and cholangiocarcinoma: A review[J]. Parasitol Res, 2017, 116(1): 11-19. |
| [11] | van Tong H, Brindley PJ, Meyer CG, et al. Parasite infection, carcinogenesis and human malignancy[J]. EBio Medicine, 2017, 15: 12-23. |
| [12] | Nam JH, Moon JH, Kim IK, et al. Free radicals enzymatically triggered by Clonorchis sinensis excretory-secretory products cause NF-κB-mediated inflammation in human cholangiocarcinoma cells[J]. Int J Parasitol, 2012, 42(1): 103-113. |
| [13] | Won J, Ju JW, Kim SM, et al. Clonorchis sinensis infestation promotes three-dimensional aggregation and invasion of cholangiocarcinoma cells[J]. PLoS One, 2014, 9(10): e110705. |
| [14] | Lala PK, Chakraborty C. Role of nitric oxide in carcinogenesis and tumour progression[J]. Lancet Oncol, 2001, 2(3): 149-156. |
| [15] | Albiach-Delgado A, Pinilla-González A, Cascant-Vilaplana MM, et al. The effect of inhaled nitric oxide treatment on biomarkers of oxidative/nitrosative damage to proteins and DNA/RNA[J]. Free Radic Biol Med, 2025, 228: 350-359. |
| [16] | Kim DW, Kim JY, Moon JH, et al. Transcriptional induction of minichromosome maintenance protein 7 (Mcm7) in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory―secretory products[J]. Mol Biochem Parasitol, 2010, 173(1): 10-16. |
| [17] | Yan C, Zhou QY, Wu J, et al. Csi-let-7a-5p delivered by extracellular vesicles from a liver fluke activates M1-like macrophages and exacerbates biliary injuries[J]. Proc Natl Acad Sci USA, 2021, 118(46): e2102206118. |
| [18] | Xu MJ, Liu Q, Nisbet AJ, et al. Identification and characterization of microRNAs in Clonorchis sinensis of human health significance[J]. BMC Genomics, 2010, 11: 521. |
| [19] | Ovchinnikov VY, Afonnikov DA, Vasiliev GV, et al. Identification of microRNA genes in three opisthorchiids[J]. PLoS Negl Trop Dis, 2015, 9(4): e0003680. |
| [20] | Ovchinnikov VY, Mordvinov VA, Fromm B. Extreme conservation of miRNA complements in opisthorchiids[J]. Parasitol Int, 2017, 66(6): 773-776. |
| [21] | Stark VA, Facey COB, Viswanathan V, et al. The role of miRNAs, miRNA clusters, and isomiRs in development of cancer stem cell populations in colorectal cancer[J]. Int J Mol Sci, 2021, 22(3): 1424. |
| [22] | Bahrami A, Jafari A, Ferns GA. The dual role of microRNA-9 in gastrointestinal cancers: OncomiR or tumor suppressor?[J]. Biomed Pharmacother, 2022, 145: 112394. |
| [23] | 魏伟, 孙云异, 毛瑞锋, 等. 华支睾吸虫细胞外囊泡中miRNAs调控宿主靶基因的预测及生物信息学分析[J]. 黑龙江畜牧兽医, 2023(17): 1-6, 12, 139. |
| Wei W, Sun YY, Mao RF, et al. Prediction and bioinformatic analysis of host target genes regulated by miRNAs in the extracellular membrane vesicles of Clonorchis sinensis[J]. Heilongjiang Anim Sci Vet Med, 2023(17): 1-6, 12, 139. (in Chinese) | |
| [24] | Ge QY, Chen J, Li GX, et al. GRAMD 4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma[J]. Clin Transl Med, 2021, 11(11): e635. |
| [25] | 刘清波, 王卫东, 陈小伍, 等. 华支睾吸虫感染的肝内胆管癌上皮组织miR-215与PTEN表达的关系[J]. 中华肿瘤防治杂志, 2016, 23(8): 515-519. |
| Liu QB, Wang WD, Chen XW, et al. Expression of miR-215 and PTEN in intrahepatic cholangiocarcinoma tissue with Clonorchis sinensis infection[J]. Chin J Cancer Prev Treat, 2016, 23(8): 515-519. (in Chinese) | |
| [26] | Hu CH, Huang FZ, Deng G, et al. miR-31 promotes oncogenesis in intrahepatic cholangiocarcinoma cells via the direct suppression of RASA1[J]. Exp Ther Med, 2013, 6(5): 1265-1270. |
| [27] | Pak JH, Kim IK, Kim SM, et al. Induction of cancer-related microRNA expression profiling using excretory-secretory products of Clonorchis sinensis[J]. Parasitol Res, 2014, 113(12): 4447-4455. |
| [28] | Yin XL, Chai ZT, Sun XT, et al. Overexpression of microRNA-96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1[J]. Exp Ther Med, 2020, 19(4): 2757-2765. |
| [29] | Tang CF, Yuan P, Wang J, et al. miR-192-5p regulates the proliferation and apoptosis of cholangiocarcinoma cells by activating MEK/ERK pathway[J]. 3 Biotech, 2021, 11(2): 99. |
| [30] | Wan PQ, Chi X, Du Q, et al. miR-383 promotes cholangiocarcinoma cell proliferation, migration, and invasion through targeting IRF1[J]. J Cell Biochem, 2018, 119(12): 9720-9729. |
| [31] | Tian F, Chen J, Zheng SG, et al. miR-124 targets GATA6 to suppress cholangiocarcinoma cell invasion and metastasis[J]. BMC Cancer, 2017, 17(1): 175. |
| [32] | 汪正广, 徐阿曼, 朱亮, 等. miR125a对胆管癌细胞株QBC939增殖、凋亡影响及可能机制[J]. 中国药理学通报, 2012, 28(10): 1428-1431. |
| Wang ZG, Xu AM, Zhu L, et al. Effects of miR125a on cell cycle and apoptosis of cholangiocarcinoma cell line QBC939 and its mechanism[J]. Chin Pharmacol Bull, 2012, 28(10): 1428-1431. (in Chinese) | |
| [33] | Chen C, Jiang JQ, Fang M, et al. microRNA-129-2-3p directly targets Wip1 to suppress the proliferation and invasion of intrahepatic cholangiocarcinoma[J]. J Cancer, 2020, 11(11): 3216-3224. |
| [34] | Tang Y, Tang ZY, Yang JR, et al. microRNA-7-5p inhibits migration, invasion and metastasis of intrahepatic cholangiocarcinoma by inhibiting MyD88[J]. J Clin Transl Hepatol, 2021, 9(6): 809-817. |
| [35] | 潘超, 许蔚, 刘子君, 等. miR-200c/ZEB1/E-cadherin轴在胆管癌转移侵袭中的作用及对胆管癌预后评估的价值[J]. 现代肿瘤医学, 2024, 32(7): 1287-1294. |
| Pan C, Xu W, Liu ZJ, et al. Value of miR-200c/ZEB1/E-cadherin axis in the metastasis and invasion of cholangiocarcinoma and its implications for the prognosis evaluation of cholangiocarcinoma[J]. J Mod Oncol, 2024, 32(7): 1287-1294. (in Chinese) |
/
| 〈 |
|
〉 |