收稿日期: 2024-01-29
修回日期: 2024-05-23
网络出版日期: 2024-07-16
基金资助
辽宁省科技厅课题(2022-MS-239)
Research advances on transmission-blocking vaccines targeting Plasmodium sexual stage
Received date: 2024-01-29
Revised date: 2024-05-23
Online published: 2024-07-16
Supported by
Liaoning Provincial Department of Science and Technology Project(2022-MS-239)
王蓉 , 徐洁 , 朱晓彤 . 疟原虫有性生殖传播阻断疫苗的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2024 , 42(3) : 399 -406 . DOI: 10.12140/j.issn.1000-7423.2024.03.017
Malaria remains a major global health challenge. At present, due to the application of drugs and related technologies, the burden of disease has been reduced to a certain extent, but morbidity and mortality remain very high. With the widespread emergence of drug resistance, it is urgent to explore and develop new anti-malarial strategies to effectively control and block the spread of malaria. The transmission-blocking vaccine (TBV), which targets the sexual stage, is a good option to control the transmission of Plasmodium from human hosts to mosquito vectors. The development of TBV has attracted attention domestically and internationally. It is considered to be one of the new technologies for malaria control. This article summarizes the research and development of TBV, as well as the discovery and progress of candidate antigens, and provides a theoretical reference for further research on TBV.
Key words： Malaria; Plasmodium; Transmission-blocking vaccine; Candidate antigen
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