收稿日期: 2023-03-21
修回日期: 2023-05-29
网络出版日期: 2023-11-06
基金资助
国家自然科学基金(32000445);湖南省自然科学基金(2022JJ40368)
Research advances on transcriptional regulation in plasmodium sexual stages
Received date: 2023-03-21
Revised date: 2023-05-29
Online published: 2023-11-06
Supported by
National Natural Science Foundation of China(32000445);Provincial Natural Science Foundation of Hunan(2022JJ40368)
疟疾是由疟原虫感染所致的传染性疾病。疟疾的传播依赖于疟原虫在脊椎动物和按蚊两个宿主内的交替发育。疟原虫有性配子体阶段是其从脊椎动物传递至按蚊的唯一阶段。疟原虫的有性转化、有性发育和配子发生对疟原虫的传播起重要作用。深入了解疟原虫有性阶段的基因表达及相关调控机制，有助于筛选新的抗疟药物或疫苗靶点。本文对疟原虫有性阶段基因表达转录调控的研究进展进行综述，以期为阻断疟疾传播提供参考。
关键词： 疟原虫; 配子体; 转录调控; ApiAP2转录因子
梁柯嘉 , 刘聪 , 李彦霖 , 李小鸽 , 刘彦 , 李贞魁 . 疟原虫有性阶段转录调控的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023 , 41(5) : 619 -624 . DOI: 10.12140/j.issn.1000-7423.2023.05.014
Malaria is a worldwide infectious disease caused by the Plasmodium spp. Malaria transmission depends on the alternate development of malaria parasites in both vertebrate and anopheles hosts. The sexual stage, consisting of male and female gametocytes, is the only infectious stage in which Plasmodium is transmitted from their vertebrates host to Anopheles mosquitoes. The gametocyte-related processes, including sexual commitment, gametocytogenesis, and subsequent gametogenesis, are critical for Plasmodium transmission. An in-depth understanding of gene expression and regulatory mechanisms in the sexual stage of malaria parasites contributes to the identification of targets for new antimalarial drugs or vaccines. In this review, recent research focusing on transcriptional regulation in the sexual stages was reviewed to provide a comprehensive understanding of gene expression and transcriptional regulation.
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