收稿日期: 2023-05-12
修回日期: 2023-07-17
网络出版日期: 2023-09-06
基金资助
北京市自然科学基金面上项目(7222007);首都医科大学长学制导师项目(CXZDS2022010)
Research progress on the immune evasion mechanism in Trichinella spiralis infection
Received date: 2023-05-12
Revised date: 2023-07-17
Online published: 2023-09-06
Supported by
Beijing Natural Science Foundation of China(7222007);Capital Medical University Division Project(CXZDS2022010)
张旭 , 孙希萌 . 旋毛虫感染免疫逃逸机制研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023 , 41(4) : 492 -496 . DOI: 10.12140/j.issn.1000-7423.2023.04.016
Trichinella spiralis infection can cause zoonotic trichinellosis that seriously endangers human health. During the entire T. spiralis life cycle stages, the parasite can manipulate the host's immune responses. The immune evasion mechanism, as a common natural selection mechanism, is an adaptation of pathogens to the immune system under natural selection. It enables the pathogens to relieve or alleviate the host's immune responses, avoid attacking from the immune system, and ensure that they can survive and reproduce. This paper reviewed the research advance of T. spiralis immune evasion mechanism in disturbing complement response, innate immune response, humoral immune response, and T cell immune response. Further research of the immune evasion mechanism of T. spiralis is of great significance for the prevention and control of trichinosis, the treatment of human autoimmune diseases, and allergic diseases.
Key words： Trichinella spiralis; Immune evasion; Immune response; Immunotherapy
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