收稿日期: 2022-10-12
修回日期: 2023-04-24
网络出版日期: 2023-05-30
基金资助
国家重点研发计划(2018YFE0121600)
Research progress on transcription regulation of rif gene in Plasmodium falciparum
Received date: 2022-10-12
Revised date: 2023-04-24
Online published: 2023-05-30
Supported by
National Key Research and Development Program of China(2018YFE0121600)
徐少杰 , 陈绅波 , 陈军虎 . 恶性疟原虫重复散布家族基因转录调控的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023 , 41(3) : 374 -379 . DOI: 10.12140/j.issn.1000-7423.2023.03.017
Plasmodium falciparum-infected erythrocytes express multiple polymorphic proteins known as variant surface antigens, which are associated with symptomatic and severe malaria. The repetitive interspersed family (rif) gene is one of the largest gene families of the P. falciparum multicopy gene families which potentially encode variant antigens. Studying the regulation of rif genes, such as histone modification, repressor element regulation and the involvement of expressed proteins in immune evasion, is of great significance. Based on the current research, we made a comprehensive summary of the rif gene expression regulation mechanisms to understand the pathogenic mechanism of P. falciparum.
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