收稿日期: 2022-05-11
修回日期: 2022-06-21
网络出版日期: 2023-04-19
基金资助
广西自然科学基金面上项目(20191JA140480);国家自然科学基金地区项目(8196080417)
Research progress on the cellular signal pathways associated in alveolar echinococcosis
Received date: 2022-05-11
Revised date: 2022-06-21
Online published: 2023-04-19
Supported by
Guangxi Natural Science Foundation(20191JA140480);National Natural Science Foundation of China(8196080417)
马慧 , 种世桂 , 陈根 , 张伶慧 , 秦俊梅 , 赵玉敏 . 多房棘球蚴病相关细胞信号通路的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023 , 41(2) : 223 -227 . DOI: 10.12140/j.issn.1000-7423.2023.02.016
Alveolar echinococcosis (AE) is a highly harmful zoonotic parasitic disease, which is prevalent in the high latitudes of the northern hemisphere. AE usually occurs in liver tissue and Echinococcus grows infiltratively in patients. It can cause serious damage to the morphology and physiological function of the involved organs. In this process, the cellular signaling pathway is closely related to the course of AE. Cell signaling pathways, such as the mitogen-activated protein kinases (MAPK) pathway, insulin (Ins) pathway, programmed cell death protein 1 (PD-1) pathway and transforming growth factor β (TGF-β) pathway, are closely related to proliferation of Echinococcus, body immune response and differentiation of immune cells. This article has reviewed the role of related cellular signaling pathways in the immune regulation of alveolar echinococcosis and host in the process of AE infection.
| [1] | Ni XW, Yan HB, Lou ZZ, et al. The signaling systems in Echinococcus multilocularis[J]. Chin J Parasitol Parasit Dis, 2012, 30(3): 233-237. (in Chinese) |
| (倪兴维, 闫鸿斌, 娄忠子, 等. 多房棘球绦虫信号转导体系[J]. 中国寄生虫学与寄生虫病杂志, 2012, 30(3): 233-237.) | |
| [2] | Woolsey ID, Miller AL. Echinococcus granulosus sensulato and Echinococcus multilocularis: a review[J]. Res Vet Sci, 2021, 135: 517-522. |
| [3] | Zhang LH, Chen G, Chong SG, et al. Research progress on the immune regulation mechanism in alveolar echinococcosis[J]. Chin J Parasitol Parasit Dis, 2022, 40(1): 109-113, 120. (in Chinese) |
| (张伶慧, 陈根, 种世桂, 等. 多房棘球蚴病中免疫细胞调控机制的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(1): 109-113, 120.) | |
| [4] | Casulli A, Barth TFE, Tamarozzi F. Echinococcus multilocularis[J]. Trends Parasitol, 2019, 35(9): 738-739. |
| [5] | Hemphill A, Stadelmann B, Rufener R, et al. Treatment of echinococcosis: albendazole and mebendazole--what else?[J]. Parasite, 2014, 21: 70. |
| [6] | Wang J, Gottstein B. Immunoregulation in larval Echinococcus multilocularis infection[J]. Parasite Immunol, 2016, 38(3): 182-192. |
| [7] | Chong SG, Chen G, Dang ZS, et al. Echinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis[J]. Bioengineered, 2022, 13(4): 8747-8758. |
| [8] | Liang YJ, Yang WX. Kinesins in MAPK cascade: how kinesin motors are involved in the MAPK pathway?[J]. Gene, 2019, 684: 1-9. |
| [9] | Sun Y, Liu WZ, Liu T, et al. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis[J]. J Recept Signal Transduct, 2015, 35(6): 600-604. |
| [10] | Wang CH, Lv HL, Jiang YF, et al. Advances in research on the MAPK signal transduction pathway of Echinococcus[J]. Chin J Parasitol Parasit Dis, 2013, 31(1): 60-63. (in Chinese) |
| (王成华, 吕海龙, 姜玉峰, 等. 棘球蚴MAPK信号转导通路的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2013, 31(1): 60-63.) | |
| [11] | Zhao YM, Gui WF, Chong SG. Advances in parasitology research on the role of the MAPK signal transduction pathway[J]. J Pathog Biol, 2017, 12(5): 480-483. (in Chinese) |
| (赵玉敏, 桂炜峰, 种世桂. MAPK在寄生虫领域的研究进展[J]. 中国病原生物学杂志, 2017, 12(5): 480-483.) | |
| [12] | Weiss JM, Davies LC, Karwan M, et al. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors[J]. J Clin Invest, 2018, 128(9): 3794-3805. |
| [13] | Gaire BP, Song MR, Choi JW. Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization[J]. J Neuroinflammation, 2018, 15(1): 284. |
| [14] | Moore MP, Cunningham RP, Davis RAH, et al. A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice[J]. Am J Physiol Gastrointest Liver Physiol, 2021, 320(4): G564-G572. |
| [15] | Luo Y, Shao LJ, Chang JH, et al. M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion[J]. Blood Adv, 2018, 2(8): 859-870. |
| [16] | Gui WF, Xu S, Dang ZS, et al. In vitro and in vivo effect of MAPK signal transduction pathway inhibitors on Echinococcus multilocularis[J]. J Parasitol, 2019, 105(1): 146-154. |
| [17] | Dang ZS, Oku Y, Zhou XN, et al. In vitro inhibitive effect of the anticancer drug sorafenib on Echinococcus multilocularis larvae[J]. Chin J Parasitol Parasit Dis, 2017, 35(5): 417-422. |
| (党志胜, 奥祐三郎, 周晓农, 等. 抗癌药物索拉非尼体外抗多房棘球蚴的效果评价(英文)[J]. 中国寄生虫学与寄生虫病杂志, 2017, 35(5): 417-422.) | |
| [18] | Sun ZM, Qi YJ. Insulin signaling pathway and insulin resistance[J]. World Latest Med Inf, 2019, 19(52): 62-63. (in Chinese) |
| (孙志梅, 齐亚娟. 胰岛素信号通路与胰岛素抵抗[J]. 世界最新医学信息文摘, 2019, 19(52): 62-63.) | |
| [19] | Das D, Arur S. Conserved insulin signaling in the regulation of oocyte growth, development, and maturation[J]. Mol Reprod Dev, 2017, 84(6): 444-459. |
| [20] | Hemer S, Konrad C, Spiliotis M, et al. Host insulin stimulates Echinococcus multilocularis insulin signalling pathways and larval development[J]. BMC Biol, 2014, 12: 5. |
| [21] | Brehm K, Spiliotis M. The influence of host hormones and cytokines on Echinococcus multilocularis signalling and development[J]. Parasite, 2008, 15(3): 286-290. |
| [22] | Brehm K. The role of evolutionarily conserved signalling systems in Echinococcus multilocularis development and host-parasite interaction[J]. Med Microbiol Immunol, 2010, 199(3): 247-259. |
| [23] | Brehm K. Echinococcus multilocularis as an experimental model in stem cell research and molecular host-parasite interaction[J]. Parasitology, 2010, 137(3): 537-555. |
| [24] | Konrad C, Kroner A, Spiliotis M, et al. Identification and molecular characterisation of a gene encoding a member of the insulin receptor family in Echinococcus multilocularis[J]. Int J Parasitol, 2003, 33(3): 301-312. |
| [25] | Ahier A, Khayath N, Vicogne J, et al. Insulin receptors and glucose uptake in the human parasite Schistosoma mansoni[J]. Parasite, 2008, 15(4): 573-579. |
| [26] | Miller CM, Newmark PA. An insulin-like peptide regulates size and adult stem cells in planarians[J]. Int J Dev Biol, 2012, 56(1/2/3): 75-82. |
| [27] | Ai LY, Xu AT, Xu J. Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond[J]. Adv Exp Med Biol, 2020, 1248: 33-59. |
| [28] | Ghosh C, Luong G, Sun Y. A snapshot of the PD-1/PD-L1 pathway[J]. J Cancer, 2021, 12(9): 2735-2746. |
| [29] | Hafalla JCR, Claser C, Couper KN, et al. The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology[J]. PLoS Pathog, 2012, 8(2): e1002504. |
| [30] | Bhadra R, Gigley JP, Weiss LM, et al. Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade[J]. Proc Natl Acad Sci USA, 2011, 108(22): 9196-9201. |
| [31] | Roy S, Gupta P, Palit S, et al. The role of PD-1 in regulation of macrophage apoptosis and its subversion by Leishmania donovani[J]. Clin Transl Immunol, 2017, 6(5): e137. |
| [32] | Zhang YM, Wu YL, Liu H, et al. Granulocytic myeloid-derived suppressor cells inhibit T follicular helper cells during experimental Schistosoma japonicum infection[J]. Parasit Vectors, 2021, 14(1): 497. |
| [33] | Vuitton DA, Zhang SL, Yang YR, et al. Survival strategy of Echinococcus multilocularis in the human host[J]. Parasitol Int, 2006, 55: S51-S55. |
| [34] | La XL, Zhang FB, Li YH, et al. Upregulation of PD-1 on CD4+CD25+T cells is associated with immunosuppression in liver of mice infected with Echinococcus multilocularis[J]. Int Immunopharmacol, 2015, 26(2): 357-366. |
| [35] | Jebbawi F, Bellanger AP, Lunstr?m-Stadelmann B, et al. Innate and adaptive immune responses following PD-L1 blockade in treating chronic murine alveolar echinococcosis[J]. Parasite Immunol, 2021, 43(8): e12834. |
| [36] | Wang JH, Jebbawi F, Bellanger AP, et al. Immunotherapy of alveolar echinococcosis via PD-1/PD-L1 immune checkpoint blockade in mice[J]. Parasite Immunol, 2018, 40(12): e12596. |
| [37] | Derynck R, Budi EH. Specificity, versatility, and control of TGF-β family signaling[J]. Sci Signal, 2019, 12(570): eaav5183. |
| [38] | Zhang Y, Alexander PB, Wang XF. TGF-β family signaling in the control of cell proliferation and survival[J]. Cold Spring Harb Perspect Biol, 2017, 9(4): a022145. |
| [39] | Morikawa M, Derynck R, Miyazono K. TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology[J]. Cold Spring Harb Perspect Biol, 2016, 8(5): a021873. |
| [40] | Xu FY, Liu CW, Zhou DD, et al. TGF-β/SMAD pathway and its regulation in hepatic fibrosis[J]. J Histochem Cytochem, 2016, 64(3): 157-167. |
| [41] | Syed V. TGF-β signaling in cancer[J]. J Cell Biochem, 2016, 117(6): 1279-1287. |
| [42] | Zhang SL, Hüe S, Sène D, et al. Expression of major histocompatibility complex class Ⅰ chain-related molecule A, NKG2D, and transforming growth factor-beta in the liver of humans with alveolar echinococcosis: new actors in the tolerance to parasites?[J]. J Infect Dis, 2008, 197(9): 1341-1349. |
| [43] | Nono JK, Lutz MB, Brehm K. Expansion of host regulatory T cells by secreted products of the tapeworm Echinococcus multilocularis[J]. Front Immunol, 2020, 11: 798. |
| [44] | Wang JH, Zhang CS, Wei XF, et al. TGF-β and TGF-β/Smad signaling in the interactions between Echinococcus multilocularis and its hosts[J]. PLoS One, 2013, 8(2): e55379. |
| [45] | Pang NN, Zhang FB, Ma XM, et al. TGF-β/Smad signaling pathway regulates Th17/Treg balance during Echinococcus multilocularis infection[J]. Int Immunopharmacol, 2014, 20(1): 248-257. |
| [46] | Yan C, Wang L, Li B, et al. The expression dynamics of transforming growth factor-β/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis[J]. Parasit Vectors, 2015, 8(1): 70. |
| [47] | Chen BL, Peng J, Li QF, et al. Exogenous bone morphogenetic protein-7 reduces hepatic fibrosis in Schistosoma japonicum-infected mice via transforming growth factor-β/Smad signaling[J]. World J Gastroenterol, 2013, 19(9): 1405-1415. |
| [48] | Yin S, Chen X, Zhang J, et al. The effect of Echinococcus granulosus on spleen cells and TGF-β expression in the peripheral blood of BALB/c mice[J]. Parasite Immunol, 2017, 39(3): e12415. |
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