收稿日期: 2021-05-18
修回日期: 2021-07-02
网络出版日期: 2022-01-06
基金资助
上海市自然科学基金(19ZR1462600);国家科技重大专项(2018ZX10102001);国家自然科学基金面上项目(81971969);国家自然科学基金面上项目(81772225)
Research progress on the role of immune cells in liver fibrosis due to schistosomiasis
Received date: 2021-05-18
Revised date: 2021-07-02
Online published: 2022-01-06
Supported by
Natural Science Foundation of Shanghai(19ZR1462600);National Science and Technology Major Project of the Ministry of Science and Technology of China(2018ZX10102001);National Natural Science Foundation of China(81971969);National Natural Science Foundation of China(81772225)
高元 , 胡媛 , 曹建平 . 免疫细胞对血吸虫病肝纤维化作用的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022 , 40(1) : 88 -93 . DOI: 10.12140/j.issn.1000-7423.2022.01.013
Schistosomiasis is a widespread zoonotic parasitic disease. After infected, Schistosoma japonicum deposit eggs in the host liver, forming granulomatous, and consequently leading to liver fibrosis, and even cirrhosis in severe cases. Recent studies have reported that immune cells play critical roles in liver fibrosis. Helper T 17 cells, γδ T cells and dendritic cells may advance schistosomiasis liver fibrosis, while regulatory T cells and natural killer cells suppress the liver fibrosis, and B cells, macrophages and natural killer T cells may play dual roles. Here we reviewed the action mechanisms of different types of immune cells in liver fibrosis of schistosomiasis.
Key words： Schistosomiasis; Liver fibrosis; Immune cell; Cytokine
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