收稿日期: 2020-11-12
修回日期: 2020-12-02
网络出版日期: 2021-06-04
基金资助
国家自然科学基金面上项目(81971955);国家自然科学基金面上项目(81873218);广东省自然科学基金面上项目(2019A1515011667);广东省自然科学基金面上项目(2021A1515012115)
The interactions between malaria and gut microbiota
Received date: 2020-11-12
Revised date: 2020-12-02
Online published: 2021-06-04
Supported by
Grants from the National Natural Science Foundation of China(81971955);Grants from the National Natural Science Foundation of China(81873218);Natural Science Foundation of Guangdong Province(2019A1515011667);Natural Science Foundation of Guangdong Province(2021A1515012115)
钟秋婷 , 宋健平 , 吕芳丽 . 疟疾和肠道菌群的相互影响[J]. 中国寄生虫学与寄生虫病杂志, 2021 , 39(4) : 520 -525 . DOI: 10.12140/j.issn.1000-7423.2021.04.016
Intestine is the largest and most important micro-ecosystem in the human body, and gut microbiota is closely related to human health and various diseases. This review summarizes the relationship between gut microbiota and diseases, the impact of malaria on gut microbiota, including damage of gastrointestinal type malaria to the intestine, and alterations of the composition, constitution, and function of gut microbiota caused by malaria; and the impact of gut microbiota on malaria, including the impact of gut microbiota on the risk of malaria and the outcome of malaria. Exploring the interactions between malaria and gut microbiota may provide clues for prevention and control of malaria.
Key words： Malaria; Gut microbiota; Interaction
| [1] | World Health Organization. World malaria report 2020[R]. Geneva: World Health Organization, 2020. |
| [2] | LYU FL. The interaction between the COVID-19 pandemic and malaria[J/OL]. J Trop Med, 1-6. [2021-05-13]. http://kns.cnki.net/kcms/detail/44.1503.R.20210305.2024.002.html.(in Chinese) |
| [2] | (吕芳丽. 新型冠状病毒肺炎疫情与疟疾的相互影响[J/OL]. 热带医学杂志: 1-6. [2021-05-13]. http://kns.cnki.net/kcms/detail/44.1503.R.20210305.2024.002.html.) |
| [3] | Lozupone CA, Stombaugh JI, Gordon JI, et al. Diversity, stability and resilience of the human gut microbiota[J]. Nature, 2012, 489(7415):220-230. |
| [4] | Gomaa EZ. Human gut microbiota/microbiome in health and diseases: a review[J]. Antonie van Leeuwenhoek, 2020, 113(12):2019-2040. |
| [5] | Xu M, Shen YJ. Progress of research on the interplay between helminth and intestinal protozoa and gut microbiota[J]. Chin J Schisto Control, 2019, 31(1):77-85, 93. (in Chinese) |
| [5] | (徐梦, 沈玉娟. 蠕虫及肠道原虫感染与肠道菌群关系研究进展[J]. 中国血吸虫病防治杂志, 2019, 31(1):77-85, 93.) |
| [6] | Wang YY, Liu F, Urban JF Jr, et al. Ascaris suum infection was associated with a worm-independent reduction in microbial diversity and altered metabolic potential in the porcine gut microbiome[J]. Int J Parasitol, 2019, 49(3/4):247-256. |
| [7] | White EC, Houlden A, Bancroft AJ, et al. Manipulation of host and parasite microbiotas: survival strategies during chronic nematode infection[J]. Sci Adv, 2018, 4(3):eaap7399. |
| [8] | Beatty JK, Akierman SV, Motta JP, et al. Giardia duodenalis induces pathogenic dysbiosis of human intestinal microbiota biofilms[J]. Int J Parasitol, 2017, 47(6):311-326. |
| [9] | Ippolto MM, Denny JE, Langelier C, et al. Malaria and the microbiome: a systematic review[J]. Clin Infect Dis, 2018, 67(12):1831-1839. |
| [10] | Yilmaz B, Portugal S, Tran TM, et al. Gut microbiota elicits a protective immune response against malaria transmission[J]. Cell, 2014, 159(6):1277-1289. |
| [11] | Villarino NF, LeCleir GR, Denny JE, et al. Composition of the gut microbiota modulates the severity of malaria[J]. Proc Natl Acad Sci USA, 2016, 113(8):2235-2240. |
| [12] | Chinese Society of Microecology, Chinese Preventive Medicine Association. Chinese expert consensus on clinical application of microecological agent in digestive tract (2020 version)[J]. Chin J Microecol, 2020, 32(8):953-965. (in Chinese) |
| [12] | (中华预防医学会微生态学分会. 中国微生态调节剂临床应用专家共识(2020版)[J]. 中国微生态学杂志, 2020, 32(8):953-965.) |
| [13] | Weiss GA, Hennet T. Mechanisms and consequences of intestinal dysbiosis[J]. Cell Mol Life Sci, 2017, 74(16):2959-2977. |
| [14] | Pascale A, Marchesi N, Marelli C, et al. Microbiota and metabolic diseases[J]. Endocrine, 2018, 61(3):357-371. |
| [15] | Ma QQ, Xing CS, Long WY, et al. Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis[J]. J Neuroinflammation, 2019, 16(1):53. |
| [16] | Quigley EMM. Microbiota-brain-gut axis and neurodegenerative diseases[J]. Curr Neurol Neurosci Rep, 2017, 17(12):94. |
| [17] | Halverson T, Alagiakrishnan K. Gut microbes in neurocognitive and mental health disorders[J]. Ann Med, 2020, 52(8):423-443. |
| [18] | Kobliner V, Mumper E, Baker SM. Reduction in obsessive compulsive disorder and self-injurious behavior with Saccharomyces boulardii in a child with autism: a case report[J]. Integr Med (Encinitas), 2018, 17(6):38-41. |
| [19] | Liu YW, Liong MT, Chung YE, et al. Effects of Lactobacillus plantarum PS128 on children with autism spectrum disorder in Taiwan: a randomized, double-blind, placebo-controlled trial[J]. Nutrients, 2019, 11(4):E820. |
| [20] | Mesripour A, Meshkati A, Hajhashemi V. A synbiotic mixture augmented the efficacy of doxepin, venlafaxine, and fluvoxamine in a mouse model of depression[J]. Turk J Pharm Sci, 2020, 17(3):293-298. |
| [21] | Kantak PA, Bobrow DN, Nyby JG. Obsessive-compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG)[J]. Behav Pharmacol, 2014, 25(1):71-79. |
| [22] | Sanikhani NS, Modarressi MH, Jafari P, et al. The effect of Lactobacillus casei consumption in improvement of obsessive-compulsive disorder: an animal study[J]. Probiotics Antimicrob Proteins, 2020, 12(4):1409-1419. |
| [23] | Pandey KR, Naik SR, Vakil BV. Probiotics, prebiotics and synbiotics: a review[J]. J Food Sci Technol, 2015, 52(12):7577-7587. |
| [24] | Mantziaris V, Kolios G. Gut microbiota, atherosclerosis, and therapeutic targets[J]. Crit Pathw Cardiol, 2019, 18(3):139-142. |
| [25] | Cheng WY, Wu CY, Yu J. The role of gut microbiota in cancer treatment: friend or foe?[J]. Gut, 2020, 69(10):1867-1876. |
| [26] | Huang YF, Liu XH, Wu H, et al. The relationship between intestinal mucosal barrier and intestinal microflora[J]. Chin J Microecol, 2019, 31(12):1465-1469, 1474. (in Chinese) |
| [26] | (黄艳芬, 刘湘红, 伍浩, 等. 肠黏膜屏障与肠道菌群的相互关系[J]. 中国微生态学杂志, 2019, 31(12):1465-1469, 1474.) |
| [27] | Zhu XP, Su C. Human parasitology[M]. 9 ed. Beijing: People’s Medical Publishing House, 2018. (in Chinese). |
| [27] | (诸欣平, 苏川. 人体寄生虫学[M]. 9版. 北京: 人民卫生出版社, 2018.) |
| [28] | Wilairatana P, Meddings JB, Ho M, et al. Increased gastrointestinal permeability in patients with Plasmodium falciparum malaria[J]. Clin Infect Dis, 1997, 24(3):430-435. |
| [29] | Milner DA, Lee JJ, Frantzreb C, et al. Quantitative assessment of multiorgan sequestration of parasites in fatal pediatric cerebral malaria[J]. J Infect Dis, 2015, 212(8):1317-1321. |
| [30] | Sowunmi A, Ogundahunsi OAT, Falade CO, et al. Gastrointestinal manifestations of acute falciparum malaria in children[J]. Acta Trop, 2000, 74(1):73-76. |
| [31] | Shimada M, Hirose Y, Shimizu K, et al. Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection[J]. Trop Med Health, 2019, 47:18. |
| [32] | Taniguchi T, Miyauchi E, Nakamura S, et al. Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis[J]. Sci Rep, 2015, 5:15699. |
| [33] | Lupp C, Robertson ML, Wickham ME, et al. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of enterobacteriaceae[J]. Cell Host Microbe, 2007, 2(3):204. |
| [34] | Ouwerkerk JP, de Vos WM, Belzer C. Glycobiome: bacteria and mucus at the epithelial interface[J]. Best Pract Res Clin Gastroenterol, 2013, 27(1):25-38. |
| [35] | Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species[J]. Science, 2011, 331(6015):337-341. |
| [36] | Haque A, Best SE, Amante FH, et al. CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo[J]. PLoS Pathog, 2010, 6(12):e1001221. |
| [37] | Fan ZG, Li X, Fu HY, et al. Gut microbiota reconstruction following host infection with blood-stage Plasmodium berghei ANKA strain in a murine model[J]. Curr Med Sci, 2019, 39(6):883-889. |
| [38] | Denny JE, Powers JB, Castro HF, et al. Differential sensitivity to Plasmodium yoelii infection in C57BL/6 mice impacts gut-liver axis homeostasis[J]. Sci Rep, 2019, 9(1):3472. |
| [39] | Lorenzo-Zúñiga V, Bartolí R, Planas R, et al. Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats[J]. Hepatology, 2003, 37(3):551-557. |
| [40] | Fan ZG. Changes of intestinal microflora and cellular immune and its mechanism in malaria mice in early erythrocytic stage[D]. Wuhan: Huazhong University of Science and Technology, 2019. (in Chinese) |
| [40] | (范志刚. 红内期早期疟鼠肠道菌群和细胞免疫改变及其机制[D]. 武汉: 华中科技大学, 2019.) |
| [41] | Mandal RK, Crane RJ, Berkley JA, et al. Longitudinal analysis of infant stool bacteria communities before and after acute febrile malaria and artemether-lumefantrine treatment[J]. J Infect Dis, 2019, 220(4):687-698. |
| [42] | Denny JE, Schmidt NW. Oral administration of clinically relevant antimalarial drugs does not modify the murine gut microbiota[J]. Sci Rep, 2019, 9(1):11952. |
| [43] | Takem EN, Roca A, Cunnington A. The association between malaria and non-typhoid Salmonella bacteraemia in children in sub-Saharan Africa: a literature review[J]. Malar J, 2014, 13(1):1-13. |
| [44] | Potts RA, Tiffany CM, Pakpour N, et al. Mast cells and histamine alter intestinal permeability during malaria parasite infection[J]. Immunobiology, 2016, 221(3):468-474. |
| [45] | Chau JY, Tiffany CM, Nimishakavi S, et al. Malaria-associated L-arginine deficiency induces mast cell-associated disruption to intestinal barrier defenses against nontyphoidal Salmonella bacteremia[J]. Infect Immun, 2013, 81(10):3515-3526. |
| [46] | Mooney JP, Butler BP, Lokken KL, et al. The mucosal inflammatory response to non-typhoidal Salmonella in the intestine is blunted by IL-10 during concurrent malaria parasite infection[J]. Mucosal Immunol, 2014, 7(6):1302-1311. |
| [47] | Mooney JP, Lokken KL, Byndloss MX, et al. Inflammation-associated alterations to the intestinal microbiota reduce colonization resistance against non-typhoidal Salmonella during concurrent malaria parasite infection[J]. Sci Rep, 2015, 5:14603. |
| [48] | Alamer E, Carpio VH, Ibitokou SA, et al. Dissemination of non-typhoidal Salmonella during Plasmodium chabaudi infection affects anti-malarial immunity[J]. Parasitol Res, 2019, 118(7):2277-2285. |
| [49] | Yooseph S, Kirkness EF, Tran TM, et al. Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection[J]. BMC Genomics, 2015, 16:631. |
| [50] | Ngwa CJ, Pradel G. Coming soon: probiotics-based malaria vaccines[J]. Trends Parasitol, 2015, 31(1):2-4. |
| [51] | Aguilar R, Ubillos I, Vidal M, et al. Antibody responses to α-Gal in African children vary with age and site and are associated with malaria protection[J]. Sci Rep, 2018, 8(1):9999. |
| [52] | Cabezas-Cruz A, Mateos-Hernández L, Alberdi P, et al. Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases[J]. Exp Mol Med, 2017, 49(3):e301. |
| [53] | de Kivit S, Tobin MC, Forsyth CB, et al. Regulation of intestinal immune responses through TLR activation: implications for pro- and prebiotics[J]. Front Immunol, 2014, 5:60. |
| [54] | Kumar H, Salminen S, Verhagen H, et al. Novel probiotics and prebiotics: road to the market[J]. Curr Opin Biotechnol, 2015, 32:99-103. |
| [55] | Pérez-Mazliah D, Ng DH, Freitas do Rosário AP, et al. Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria[J]. PLoS Pathog, 2015, 11(3):e1004715. |
| [56] | Butler NS, Moebius J, Pewe LL, et al. Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection[J]. Nat Immunol, 2011, 13(2):188-195. |
| [57] | Curd RD, Birdsall B, Kadekoppala M, et al. The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design[J]. Open Biol, 2014, 4:130091. |
| [58] | Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity[J]. Nat Rev Immunol, 2016, 16(6):341-352. |
| [59] | Chakravarty S, Mandal RK, Duff ML, et al. Intestinal short-chain fatty acid composition does not explain gut microbiota-mediated effects on malaria severity[J]. PLoS One, 2019, 14(3):e0214449. |
| [60] | Stough JM, Dearth SP, Denny JE, et al. Functional characteristics of the gut microbiome in C57BL/6 mice differentially susceptible to Plasmodium yoelii[J]. Front Microbiol, 2016, 7:1520. |
| [61] | Morffy Smith CD, Gong MH, Andrew AK, et al. Composition of the gut microbiota transcends genetic determinants of malaria infection severity and influences pregnancy outcome[J]. EBio Medicine, 2019, 44:639-655. |
| [62] | Koren O, Goodrich JK, Cullender TC, et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy[J]. Cell, 2012, 150(3):470-480. |
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