收稿日期: 2019-11-26
网络出版日期: 2020-09-09
基金资助
国家自然科学基金(U1602223);云南省科技重大专项(2017ZF007);澜湄合作专项基金(2020399)
Advances in methods for detecting drug-resistance molecular markers of Plasmodium falciparum
Received date: 2019-11-26
Online published: 2020-09-09
Supported by
National Natural Science Foundation of China(U1602223);Science and Technology Major Project of Yunnan Province(2017ZF007);Special Project for Lancang-Mekong Cooperation(2020399)
叶升玉 , 成依依 , 李曼 , 周红宁 . 恶性疟原虫抗药性分子标记检测方法研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020 , 38(4) : 490 -495 . DOI: 10.12140/j.issn.1000-7423.2020.04.016
Malaria is a major tropical disease prevalent in Africa and Southeast Asia, which seriously threatens the health of local residents. The emergence and spread of Plasmodium falciparum resistance to anti-malaria drugs has challenged the realization of global malaria elimination goal. Current monitoring methods for P. falciparum drug resistance mainly include in vivo pharmacodynamic test, in vitro drug sensitivity test, and method of molecular markers of drug-resistance, of which the detection of molecular markers is widely used. This paper reviews research progress in the detection method using molecular markers for drug-resistance of P. falciparum resistance.
Key words： Plasmodium falciparum; Anti-malarial drugs; Molecular marker
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