收稿日期: 2019-10-21
网络出版日期: 2020-07-07
基金资助
国家自然科学基金(31725025);遗传工程国家重点实验室开放课题(SKLGE1904)
Advances in research on schistosome-host interactions mediated by extracellular vesicles
Received date: 2019-10-21
Online published: 2020-07-07
Supported by
National Natural Science Foundation of China(31725025);Open Research Fund of State Key Laboratory of Genetic Engineering, Fudan University(SKLGE1904)
孙成松 , 胡薇 , 汪天平 . 胞外囊泡介导血吸虫与宿主相互作用的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020 , 38(3) : 378 -382 . DOI: 10.12140/j.issn.1000-7423.2020.03.019
Extracellular vesicles are lipid-bilayer vesicles that are released by cells into the extracellular space. They contain bioactive molecules such as proteins, lipids, DNA and RNA, and can transfer effector molecules via binding to receptors of target cells or by direct fusing to, thus exerting biological function. Extracellular vesicles as a new type of intercellular signal transduction mechanism, play a critical role in regulating interaction between schistosome and host. This review underlines the researches advance on extracellular vesicles in regard to the classification, origin, structure and functions, and the role to mediate the parasite-host interactions upon secreted from schistosomes at different developmental stages, thus providing new ideas for researches on the prevention and control of schistosomiasis.
Key words： Schistosome; Extracellular vesicle; Host; Interaction mechanism
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