关键词: 吡喹酮, 埃及血吸虫病, 药物副作用

Abstract: A total of 1 627 cases of scmstosomiasis haematobium had been treated with praziquan-tel of different dosages by the Chinese Medical Team in Mali.The patients were all con-firmed by egg detection in urine examination and were divided into three groups.Group A,1187 cases,were each given a single dose of 40 mg/kg of praziquantel.In Group B,321 cas-es,were each treated with 10 mg/kg of praziquantel,t.i.d.for two days.In Group C,119cases,were each administered with one dose of 50 mg/kg of praziquantel.Three months af-ter treatment,the urine egg negative conversion rates were 88.5%,96.6% and 89.1%,re-spectively.It was showed that Group B gave the best efficacy and produced fewer side ef-fects,suggesting that the regime of praziquantel treatment given in divided doses is betterthan that given at a single dose.