罕见肝棘球蚴病伴德氏根霉DNA序列检出1例

doi:10.12140/j.issn.1000-7423.2026.04.026

中国寄生虫学与寄生虫病杂志 ›› 2026, Vol. 44 ›› Issue (4): 626-628.doi: 10.12140/j.issn.1000-7423.2026.04.026

罕见肝棘球蚴病伴德氏根霉DNA序列检出1例

王丹璞¹(), 程喻力², 孙磊³, 张宏伟¹, 张珂¹, 贾哲¹, 宋蕊⁴^,^*()

¹ 首都医科大学附属北京地坛医院普通外科，北京 100015
² 首都医科大学基础医学院病原生物学系，北京 100069
³ 首都医科大学附属北京地坛医院病理科，北京 100015
⁴ 首都医科大学附属北京地坛医院感染性疾病诊疗中心，北京 100015。

收稿日期:2026-01-15 修回日期:2026-04-18 出版日期:2026-08-30 发布日期:2026-08-26
通讯作者: * 宋蕊，女，博士，主任医师，从事感染性疾病研究。E-mail：13126595640@163.com
作者简介:王丹璞，男，硕士，住院医师，从事普外科研究。E-mail：1729875148@qq.com
作者贡献
王丹璞、程喻力、孙磊、张宏伟负责患者影像、实验室检查、病理等相关数据的采集，文献搜索及论文撰写；张珂、贾哲负责手术相关数据的采集；宋蕊负责论文修改和审核。
基金资助:
国家科技重大专项(2025ZD01900802);朝阳区临床重点专科建设项目

A case report of rare hepatic echinococcosis with detection of Rhizopus delemar DNA sequences

WANG Danpu¹(), CHENG Yuli², SUN Lei³, ZHANG Hongwei¹, ZHANG Ke¹, JIA Zhe¹, SONG Rui⁴^,^*()

¹ Department of General Surgery, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
² Department of Pathogen Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
³ Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
⁴ Center for Diagnosis and Treatment of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China

Received:2026-01-15 Revised:2026-04-18 Online:2026-08-30 Published:2026-08-26
Contact: * E-mail: 13126595640@163.com
Supported by:
National Science and Technology Major Project(2025ZD01900802);Chaoyang District Clinical Key Specialty Construction Project

摘要/Abstract

摘要：

本文报道一例罕见的肝棘球蚴病伴德氏根霉（Rhizopus delemar）DNA序列检出的病例。患者，女，35岁，因发现肝占位入院。血清免疫学检测显示肝棘球蚴IgG抗体阳性。术后病理显示肝内多发囊性病变，内含灰黄色豆渣样坏死物，镜下可见球形孢子样物残影及钙化。宏基因组检测进一步明确病原体为加拿大棘球绦虫（Echinococcus canadensis），且基因分型证实棘球蚴为在中国相对少见的G7基因型（猪株）；同时检测到德氏根霉DNA序列。患者行机器人辅助肝右后叶及S8段切除术，术后予以抗炎、保肝等对症治疗，术后患者痊愈出院。

关键词: 肝棘球蚴病, 加拿大棘球绦虫, 德氏根霉, 病理病原宏基因组探针捕获测序

Abstract:

This paper reports a rare case of hepatic echinococcosis with detection of Rhizopus delemar DNA sequences. The patient was a 35-year-old female who was admitted to the hospital due to the detection of a space-occupying lesion in the liver. Serum immunological tests indicated positive results for anti-Echinococcus IgG antibody. Postoperative pathological examination revealed multiple cystic lesions in the liver, which contained grayish-yellow tofu-like necrotic materials. Microscopic observation showed residual shadows of spherical spore-like structures and calcification. Metagenomics Capture on Pathology further identified the pathogen as Echinococcus canadensis and detected Rhizopus delemar DNA sequences. Moreover, genotyping confirmed that the hydatid cyst was of the G7 genotype (porcine strain), which is relatively rare in China. The patient underwent robot-assisted resection of the right posterior lobe and segment S8 of the liver, and received symptomatic treatments including anti-infection and liver-protective therapy postoperatively. The patient recovered completely and was discharged after surgery.

Key words: Hepatic echinococcosis, Echinococcus canadensis, Rhizopus delemar, Metagenomics capture on pathology

中图分类号:

R532.32

王丹璞, 程喻力, 孙磊, 张宏伟, 张珂, 贾哲, 宋蕊. 罕见肝棘球蚴病伴德氏根霉DNA序列检出1例[J]. 中国寄生虫学与寄生虫病杂志, 2026, 44(4): 626-628.

WANG Danpu, CHENG Yuli, SUN Lei, ZHANG Hongwei, ZHANG Ke, JIA Zhe, SONG Rui. A case report of rare hepatic echinococcosis with detection of Rhizopus delemar DNA sequences[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2026, 44(4): 626-628.

图/表 3

参考文献 14

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罕见肝棘球蚴病伴德氏根霉DNA序列检出1例

A case report of rare hepatic echinococcosis with detection of Rhizopus delemar DNA sequences

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