中国寄生虫学与寄生虫病杂志 ›› 2010, Vol. 28 ›› Issue (1): 15-66.

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寄生性蠕虫过氧化物氧还蛋白研究进展

李永光, 付宝权*   

  1. 中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室,农业部兽医公共卫生重点开放实验室,甘肃省动物寄生虫病重点实验室,兰州 730046
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-02-28 发布日期:2010-02-28

Research Progress on Peroxiredoxin in Parasitic Helminthes

LI Yong-guang,FU Bao-quan*   

  1. Key Laboratory of Animal Parasitology of Gansu Province;Key Laboratory of Veterinary Public Health of the Ministry of Agriculture;State Key Laboratory of Veterinary Etiological Biology;Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences,Lanzhou 730046,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-02-28 Published:2010-02-28

摘要: 过氧化物氧还蛋白为广泛存在于需氧生物体的过氧化物酶家族抗氧化蛋白。寄生性蠕虫过氧化物氧还蛋白不仅可以清除虫体自身代谢产生的活性氧族分子(reactive oxygen species,ROS)和活性氮族分子(reactive nitrogen species, RNS),而且在抗御宿主免疫细胞产生的ROS和RNS的潜在损伤中起着至关重要的作用。本文综述了过氧化物氧还蛋白的分类、作用机制以及寄生性蠕虫(包括吸虫、绦虫和线虫)过氧化物氧还蛋白的研究进展。

关键词: 寄生性蠕虫, 过氧化物氧还蛋白, 活性氧族, 活性氮族

Abstract: Peroxiredoxin (Prx) belongs to a peroxidase family of antioxidant enzymes distributed ubiquitously in aerobic organisms. It plays an important role in the defense of reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by parasite itself and the host immune cells. The classification, mechanism of Prx and the research progress on Prx in parasitic helminthes including trematode, cestode and nematode have been briefly reviewed in this article.

Key words: Parasitic helminth, Peroxiredoxin, Reactive oxygen species, Reactive nitrogen species