人血清锥虫溶解因子与锥虫抗血清相关蛋白

中国寄生虫学与寄生虫病杂志 ›› 2008, Vol. 26 ›› Issue (2): 13-140,.

人血清锥虫溶解因子与锥虫抗血清相关蛋白

李志,伦照荣

中山大学生命科学学院，寄生生物研究中心，广州 510275

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2008-04-30 发布日期:2008-04-30
通讯作者: 伦照荣

Human Serum Trypanosome Lytic Factor and Serum Resistance-Associated Protein of Trypanosome

LI Zhi,LUN Zhao-rong*

Center for Parasitic Organisms，School of Life Sciences，Sun Yat-sen（Zhongshan）University，Guangzhou 510275，China

Received:1900-01-01 Revised:1900-01-01 Online:2008-04-30 Published:2008-04-30
Contact: LUN Zhao-rong

摘要/Abstract

摘要： 分布于非洲的锥虫亚属布氏锥虫罗得西亚亚种和冈比亚亚种可感染人，引起人的非洲锥虫病，而布氏锥虫指名亚种、伊氏锥虫和马媾疫锥虫却不能感染人。人血清中的锥虫溶解因子和锥虫抗血清相关蛋白在其中起着关键作用。本文对人血清锥虫溶解因子和锥虫抗血清相关蛋白的研究进展进行了综述。

关键词: 锥虫亚属, 锥虫溶解因子, 抗血清相关蛋白

Abstract: Human African trypanosomiasis is caused by the infection of Trypanosoma brucei gambiense or T.b. rhodesiense， while another morphologically identical subspecies， T.b.brucei， and other closely related species， T.equiperdum and T.evansi， are considered not infectious to human. This is highly related to the trypanosome lytic factor （TLF） found in normal human serum （NHS） and the serum resistance-associated （SRA） protein of trypanosomes infectious to human. We reviewed the research progress in TLF and its role in trypanosome lysis as well as the mechanism of SRA against the TLF.

Key words: Trypanozoon, Trypanosome lytic factor （TLF）, Serum resistance-associated protein

李志;伦照荣. 人血清锥虫溶解因子与锥虫抗血清相关蛋白[J]. 中国寄生虫学与寄生虫病杂志, 2008, 26(2): 13-140,.

LIZhi;LUNZhao-rong*. Human Serum Trypanosome Lytic Factor and Serum Resistance-Associated Protein of Trypanosome[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2008, 26(2): 13-140,.