急性血吸虫病治疗后循环抗原的检测

中国寄生虫学与寄生虫病杂志 ›› 1997, Vol. 15 ›› Issue (2): 18-110.

急性血吸虫病治疗后循环抗原的检测

吴桂兰,吴小兰

武汉交通科技大学医院　武汉　430063

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1997-04-30 发布日期:1997-04-30

DETECTION OF CIRCULATING ANTIGENSIN ACUTE SCHISTOSOMIASIS PATIENTS AFTER TREATMENT

Wu Guilan, Wu Xiaolan

Wuhan Transportation Technology University Hospital, Wuhan 430063

Received:1900-01-01 Revised:1900-01-01 Online:1997-04-30 Published:1997-04-30

摘要/Abstract

摘要：

目的: 正确评价吡喹酮治疗血吸虫病的疗效, 为复治提供依据。方法: 循环抗原(CAg)检测法和病原检查法。结果: 190 例急性血吸虫病患者治疗后半年、1.5 年、3 年和4 年常规粪孵法的阴转率分别是83.7%、87.4%、99.5%和98.0%。治疗5 年后, 采用检测CAg 考核疗效, 检查164例, 阳性22 例, 阳性率为13.4%。用病原学方法核查, 阳性符合率为68.2% (15/22)。结论: 检测CAg 可减少漏诊, 且省时省力。表明在血吸虫病防治后期, 检测CAg 能考核吡喹酮的疗效和确定需要复治的病人。

关键词: 急性血吸虫病, 循环抗原检测, 疗效追踪

Abstract:

AIM: To assess the therapeutic effect of praziquantel in treating acute schistosomiasis and provide evidence for further treatment. METHODS: Circulating antigens (CAg) detection method and etiological detection method. RESULTS: One hundred and ninety acute schistosomiasis patients were treated with praziquntel. After 0.5, 1.5, 3 and 4 years, their negative rate was 83.7%, 87.4%, 99.5% and 98.0%, respectively by fecal hatching method. Five years after treatment, the therapeutic efficacy was evaluated by CAg detection method. Of 164 schistosomiasis patients, 22 were positive (13.4%). As compared with etiological detection method, the coincident positive rate was 68.2%. CONCLUSION: The CAg detection method can reduce the diagnosis-missing rate and save time and labor. Especially, during the late period of the schistosomiasis prevention and treatment, this method can be used to evaluate the therapeutic effect of praziquantel and provide evidence for further treatment of patients.

Key words: Acute schistosomiasis japonica, detection of circulating antigens, follow-up of therapeutic efficacy

吴桂兰;吴小兰. 急性血吸虫病治疗后循环抗原的检测[J]. 中国寄生虫学与寄生虫病杂志, 1997, 15(2): 18-110.

WuGuilan;WuXiaolan. DETECTION OF CIRCULATING ANTIGENSIN ACUTE SCHISTOSOMIASIS PATIENTS AFTER TREATMENT[J]. Chinese Journal of Parasitology and Parasitic Diseases, 1997, 15(2): 18-110.

[1]	柯兆明. 铜陵县1990～1999年急性血吸虫病调查分析[J]. 中国寄生虫学与寄生虫病杂志, 2001, 19(4): 18-249.
[2]	陈德基. 大山区急性血吸虫病防治对策的探讨[J]. 中国寄生虫学与寄生虫病杂志, 2000, 18(6): 19-377.
[3]	裘丽姝;冯正;张永红;李浩. 多克隆与单克隆抗体夹心ELISA法检测日本血吸虫病患者血清循环抗原[J]. 中国寄生虫学与寄生虫病杂志, 2000, 18(2): 8-93.
[4]	谢艳辉;薛纯良;娄文娴. 浸棒-夹心-胶体染料免疫试验检测血吸虫病患者循环抗原方法的建立及应用[J]. 中国寄生虫学与寄生虫病杂志, 1999, 17(3): 1-131.
[5]	薛纯良;娄文娴;吴琛耘;张恩英;谢艳辉. 检测日本血吸虫感染兔尿中循环抗原的研究[J]. 中国寄生虫学与寄生虫病杂志, 1999, 17(1): 2-8.
[6]	胡国才;王厚成. 急性血吸虫病患者治疗前后循环抗原水平的动态观察[J]. 中国寄生虫学与寄生虫病杂志, 1997, 15(2): 25-120.
[7]	肖树华; 王家龙; 王存志; 杨忠; 褚波; 杨慧; 刘榆华; 郑江; 陈名刚. 在云南大理血吸虫病流行区用蒿甲醚预防血吸虫感染的观察[J]. 中国寄生虫学与寄生虫病杂志, 1996, 14(1): 11-14.
[8]	肖树华,尤纪青,梅静艳,焦佩英,郭惠芳,杨元清. 蒿甲醚预防血吸虫感染的实验研究[J]. 中国寄生虫学与寄生虫病杂志, 1995, 13(4): 241-248.
[9]	汪少荣,程龙,周丛立,孙开俊,万安新. 湖北省汉川县1985-1993年急性血吸虫病920例分析[J]. 中国寄生虫学与寄生虫病杂志, 1995, 13(3): 169-169.
[10]	向杨，胡盛清，李毅，何永康，李岳生，余冬保. 血吸虫病患者血清前白蛋白测定的临床意义[J]. 中国寄生虫学与寄生虫病杂志, 1994, 12(4): 309-309.
[11]	秦风根. 江西省九江县新洲垦殖场急性血吸虫感染的调查[J]. 中国寄生虫学与寄生虫病杂志, 1994, 12(2): 128-128.
[12]	何世友,袁乃明. 吡喹酮治疗急性血吸虫病110例临床观察[J]. 中国寄生虫学与寄生虫病杂志, 1994, 12(1): 69-69.
[13]	钟久河,张绍基,刘志德. 鄱阳湖区急性血吸虫病与易感地带的关系[J]. 中国寄生虫学与寄生虫病杂志, 1994, 12(1): 70-71.
[14]	王以泽,李涛,程兴君,唐清华,阮方伟,王勇. 四川省南充县血吸虫病调查[J]. 中国寄生虫学与寄生虫病杂志, 1994, 12(1): 81-81.
[15]	钟克强,郭梅西. 急性血吸虫病肝脏超声显像60例观察[J]. 中国寄生虫学与寄生虫病杂志, 1993, 11(3): 235-235.