关键词: 四川并殖吸虫病, 临床分析, 皮下包块, 肺吸虫抗原, 硫双二氯酚, 卫氏肺吸虫, 远期随访, 四川肺吸虫病, 中枢神经系统, 嗜酸粒细胞

Abstract: Paragonimiasis szchuanensis is endemic in more than 30 counties and cities in Sichuan. The cerebral type is particularly dangerous. We analysed 119 cases of parago-nimiasis observed over the last 22 years. 95% were infected by ingesting raw or ina dequately cooked crabs. Clinical manifestations were characterized by viseral and subcutaneous larva migrans and thus ova could not be detected in sputum and feces. This was strikingly different from paragonimiasis westermani. 4 clinical types could be distinguished. Pulmonary type consisted of 36 cases (30%), subcutaneous type consisted of 19 cases (16%), both lung and subcutaneous types 53 cases (44.5%), and cerebral type 11 cases (9.2%). Patients were treated with bithionol.The dosage schedule was 20mg/kg t.i.d daily (78 cases) or every other day (41 cases)for 20 days duration. The immedate cure rates were 96.1% and 92.3% respectively (P0.05). 59 cases were followed 1-17 years after treatment. The long term cure rate was 98.3%. Side effects of the drug consisted of abdominal pain, diarrhea, nausea, vomiting and rash. The total rate of side effect was 40%.