髓源抑制性细胞免疫抑制功能及其在寄生虫感染领域的研究进展

doi:10.12140/j.issn.1000-7423.2021.04.014

中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (4): 505-513.doi: 10.12140/j.issn.1000-7423.2021.04.014

髓源抑制性细胞免疫抑制功能及其在寄生虫感染领域的研究进展

孙叶挺(), 曹建平, 沈玉娟^*()

中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）,国家卫生健康委员会寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心,国家级热带病国际联合研究中心,上海 200025

收稿日期:2020-10-16 修回日期:2021-01-22 出版日期:2021-08-30 发布日期:2021-08-11
通讯作者: 沈玉娟
作者简介:孙叶挺(1997-),男,硕士研究生,从事寄生虫感染免疫研究。E-mail： 18863665089@163.com
基金资助:
国家自然科学基金(81772224);国家自然科学基金(82072307);国家科技重大专项(2018ZX10713001-004)

Research progress on immunosuppressive function of myeloid-derived suppressor cells and its role in parasitic infection

SUN Ye-ting(), CAO Jian-ping, SHEN Yu-juan^*()

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China

Received:2020-10-16 Revised:2021-01-22 Online:2021-08-30 Published:2021-08-11
Contact: SHEN Yu-juan
Supported by:
National Natural Science Foundation of China(81772224);National Natural Science Foundation of China(82072307);National Major Science and Technology Projects of China(2018ZX10713001-004)

摘要/Abstract

摘要：

髓源抑制性细胞(MDSC)是一群未成熟的异质性髓系细胞,是树突状细胞、巨噬细胞、粒细胞的前体。这些前体细胞在病理条件下可被募集到如淋巴结、脾脏、外周血及肿瘤微环境中,并进一步诱导活化。活化后的MDSC可以通过各种机制抑制T细胞免疫反应,广泛存在于寄生虫感染的各阶段。本文就MDSC在寄生虫感染领域免疫抑制功能的研究进展作一综述。

关键词: 髓源抑制性细胞, 免疫抑制, 寄生虫感染

Abstract:

Myeloid-derived suppressor cells (MDSCs) are a group of immature heterogeneous myeloid cells, which are the precursors of dendritic cells, macrophages, and granulocytes. These precursor cells can be recruited to microenvironments, such as lymph nodes, spleen, peripheral blood and tumor, under pathological conditions, where they are further activated. After activation, MDSCs can suppress T cell immune response through various mechanisms, which are widely involved in different stages of parasitic infection. This review summarizes the research progress on the immunosuppressive function of MDSCs in the field of parasitic infection.

Key words: Myeloid-derived suppressor cells, Immunosuppression, Parasitic infection

中图分类号:

孙叶挺, 曹建平, 沈玉娟. 髓源抑制性细胞免疫抑制功能及其在寄生虫感染领域的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(4): 505-513.

SUN Ye-ting, CAO Jian-ping, SHEN Yu-juan. Research progress on immunosuppressive function of myeloid-derived suppressor cells and its role in parasitic infection[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2021, 39(4): 505-513.

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髓源抑制性细胞免疫抑制功能及其在寄生虫感染领域的研究进展

Research progress on immunosuppressive function of myeloid-derived suppressor cells and its role in parasitic infection

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