作者简介：秦飞宇（1998-）,女,本科生,从事寄生虫感染与免疫研究。E-mail:
收稿日期: 2019-07-06
网络出版日期: 2019-12-31
基金资助
江苏省自然科学基金青年基金项目（No. BK20180994）;江苏省高校自然科学研究基金面上项目（No. 17KJB310017）;中国博士后第63批面上资助（No. 2018M632382）;大学生创新创业训练计划项目 (No. 201910313062Y)
Research progress in the role of profilin in parasitic infection and immunity
Received date: 2019-07-06
Online published: 2019-12-31
Supported by
Supported by Natural Science Foundation of Jiangsu (No. BK20180994), Natural Science Fund of the Jiangsu Higher Education Institutions (No. 17KJB310017), the Fund for Postdoctoral Research in China (No. 2018M632382), Training Programs of Innovation and Entrepreneurship for College Students in Jiangsu Province (No. 201910313062Y)
秦飞宇 , 宋海桐 , 张昕 , 李雨迪 , 原飞 , 何成 , 刘转转 . 抑制蛋白在寄生虫感染与免疫中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2019 , 37(6) : 709 -712 . DOI: 10.12140/j.issn.1000-7423.2019.06.017
Profilin is an actin-binding protein highly conserved in all eukaryotes. It regulates the polymerization and depolymerization of actin, therefore affecting parasite movement and invasion in the host and inducing specific immune responses during parasite infection. Here we reviewed the structure and function of profilin, its role during parasite infection and immune responses in the host and its potential as a vaccine candidate and adjuvant, in order to provide reference for the better prevention and treatment of parasitic diseases.
Key words： Profilin; Parasite; Infection and immunity; Vaccine
| [1] | Daoud H, Dobrzeniecka S, Camu W, et al. Mutation analysis of PFN1 in familial amyotrophic lateral sclerosis patients[J]. Neurobiol Aging, 2013, 34(4): 1311. |
| [2] | Di Nardo A, Gareus R, Kwiatkowski D, et al. Alternative splicing of the mouse profilin Ⅱ gene generates functionally different profilin isoforms[J]. J Cell Sci, 2000, 113(21): 3795-3803. |
| [3] | Obermann H, Raabe I, Balvers M, et al. Novel testis-expressed profilin Ⅳ associated with acrosome biogenesis and spermatid elongation[J]. Mol Hum Reprod, 2005, 11(1): 53-64. |
| [4] | Mansilla FC, Capozzo AV.Apicomplexan profilins in vaccine development applied to bovine neosporosis[J]. Exp Parasitol, 2017, 183: 64-68. |
| [5] | Denkers EY, Striepen B.Deploying parasite profilin on a mission of invasion and danger[J]. Cell Host Microbe, 2008, 3(2): 61-63. |
| [6] | Olshina MA, Wong W, Baum J.Holding back the microfilament-structural insights into actin and the actin-monomer-binding proteins of apicomplexan parasites[J]. IUBMB Life, 2012, 64(5): 370-377. |
| [7] | 高琦, 张念章, 胡玲英, 等. 弓形虫profilin蛋白基因的克隆表达及序列分析[J]. 中国兽医科学, 2015, 45(1): 1-7. |
| [8] | 刘转转, 原飞, 张波, 等. 刚地弓形虫抑制蛋白主要特性分析与抗原表位预测[J]. 国际医学寄生虫病杂志, 2015, 42(6): 352-355. |
| [9] | Kadirvel P, Anishetty S.Potential role of salt-bridges in the hinge-like movement of apicomplexa specific β-hairpin of Plasmodium and Toxoplasma profilins: a molecular dynamics simulation study[J]. J Cell Biochem, 2018, 119(4): 3683-3696. |
| [10] | Moreau CA, Bhargav SP, Kumar H, et al. A unique profilin-actin interface is important for malaria parasite motility[J]. PLoS Pathog, 2017, 13(5): e1006412. |
| [11] | Denkers EY, Striepen B.Deploying parasite profilin on a mission of invasion and danger[J]. Cell Host Microbe, 2008, 3(2): 61-63. |
| [12] | Subauste CS.Interplay between Toxoplasma gondii, autophagy, and autophagy proteins[J]. Front Cell Infect Microbiol, 2019, 9: 139. |
| [13] | Yarmola EG, Bubb MR.How depolymerization can promote polymerization: the case of actin and profilin[J]. Bioessays, 2009, 31(11): 1150-1160. |
| [14] | Skruber K, Read TA, Vitriol EAK. Reconsidering an active role for G-actin in cytoskeletal regulation[J]. J Cell Sci, 2018, 131(1): jcs203760. |
| [15] | Salazar Gonzalez RM, Shehata H, O’Connell MJ, et al. Toxoplasma gondii-derived profilin triggers human Toll-like receptor 5-dependent cytokine production[J]. J Innate Immun, 2014, 6(5): 685-694. |
| [16] | Tosh KW, Mittereder L, Bonne-Annee S, et al. The IL-12 response of primary human dendritic cells and monocytes to Toxoplasma gondii is stimulated by phagocytosis of live parasites rather than host cell invasion[J]. J Immunol, 2016, 196(1): 345-356. |
| [17] | Hatai H, Lepelley A, Zeng W, et al. Toll-Like receptor 11 (TLR11) interacts with flagellin and profilin through disparate mechanisms[J]. PLoS One, 2016, 11(2): e0148987. |
| [18] | Pifer R, Benson A, Sturge CR, et al. UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii[J]. J Biol Chem, 2011, 286(5): 3307-3314. |
| [19] | Andrade WA, Souza MC, Ramos-Martinez E, et al. Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice[J]. Cell Host Microbe, 2013, 13(1): 42-53. |
| [20] | Raetz M, Kibardin A, Sturge CR, et al. Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin[J]. J Immunol, 2013, 191(9): 4818-4827. |
| [21] | Denkers EY, Striepen B.Deploying parasite profilin on a mission of invasion and danger[J]. Cell Host Microbe, 2008, 3(2): 61-63. |
| [22] | Kucera K, Koblansky AA, Saunders LP, et al. Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11[J]. J Mol Biol, 2010, 403(4): 616-629. |
| [23] | Tombácz K, Burgess G, Holder A, et al. Toxoplasma gondii profilin does not stimulate an innate immune response through bovine or human TLR5[J]. Innate Immun, 2018, 24(7): 422-429. |
| [24] | Shukla D, Chandel HS, Srivastava S, et al. TLR11 or TLR12 silencing reduces Leishmania major infection[J]. Cytokine, 2018, 104: 110-113. |
| [25] | dos Remedios CG, Chhabra D, Kekic M, et al. Actin binding proteins: regulation of cytoskeletal microfilaments[J]. Physiol Rev, 2003, 83(2): 433-473. |
| [26] | Osorio-Méndez JF, Vizcaíno-Castillo A, Manning-Cela R, et al. Expression of profilin in Trypanosoma cruzi and identification of some of its ligands[J]. Biochem Biophys Res Commun, 2016, 480(4): 709-714. |
| [27] | Gao Q, Zhang NZ, Zhang FK, et al. Immune response and protective effect against chronic Toxoplasma gondii infection induced by vaccination with a DNA vaccine encoding profilin[J]. BMC Infect Dis, 2018, 18(1): 117. |
| [28] | Tanaka S, Kuroda Y, Ihara F, et al. Vaccination with profilin encapsulated in oligomannose-coated liposomes induces significant protective immunity against Toxoplasma gondii[J]. Vaccine, 2014, 32(16): 1781-1785. |
| [29] | 刘转转, 张波, 原飞, 等. 重组刚地弓形虫抑制蛋白滴鼻免疫小鼠诱导的脾淋巴细胞免疫应答[J]. 中国血吸虫病防治杂志, 2016, 28(6): 674-677. |
| [30] | 原飞, 刘转转, 张波, 等. 刚地弓形虫抑制蛋白的原核表达与免疫反应性分析[J]. 中国寄生虫学与寄生虫病杂志, 2015, 33(1): 21-24. |
| [31] | Hedhli D, Moiré N, Akbar H, et al. The antigen-specific response to Toxoplasma gondii profilin, a TLR11/12 ligand, depends on its intrinsic adjuvant properties[J]. Med Microbiol Immunol, 2016, 205(4): 345-352. |
| [32] | Pyo KH, Lee YW, Lim SM, et al. Immune adjuvant effect of a Toxoplasma gondii profilin-like protein in autologous whole-tumor-cell vaccination in mice[J]. Oncotarget, 2016, 7(45): 74107-74119. |
| [33] | Zhang SM, Lv ZY, Zhou HJ, et al. Characterization of a profilin-like protein from Schistosoma japonicum, a potential new vaccine candidate[J]. Parasitol Res, 2008, 102(6): 1367-1374. |
| [34] | Jang SI, Kim DK, Lillehoj HS, et al. Evaluation of MontanideTM ISA 71 VG adjuvant during profilin vaccination against experimental coccidiosis[J]. PLoS One, 2013, 8(4): e59786. |
| [35] | Tang X, Suo J, Li C,et al.Transgenic Eimeria tenella expressing profilin of Eimeria maxima elicits enhanced protective immunity and alters gut microbiome of chickens[J]. Infect Immun, 2018, 86(9): e00888-17. |
/
| 〈 |
|
〉 |