综述

细粒棘球绦虫基因多态性的研究进展

  • 魏玉环 ,
  • 胡媛 ,
  • 曹建平
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  • 中国疾病预防控制中心寄生虫病预防控制所,国家热带病研究中心,世界卫生组织热带病合作中心,科技部国家级热带病国际联合研究中心,卫生部寄生虫病原与媒介生物学重点实验室,上海 200025

作者简介:魏玉环(1993-),女,硕士研究生,从事寄生虫病防控研究。E-mail:weiyh688@126.com

收稿日期: 2019-07-02

  网络出版日期: 2019-09-05

基金资助

国家科技重大专项(No. 2018ZX10102001-002-004);上海市自然科学基金(No. 19ZR1462600);国家自然科学基金(No. 81772225)

Advances in the genetic polymorphism of Echinococcus granulosus

  • Yu-huan WEI ,
  • Yuan HU ,
  • Jian-ping CAO
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  • National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention;Chinese Center for Tropical Diseases Research;WHO Collaborating Centre for Tropical Diseases;National Center for International Research on Tropical Diseases, Ministry of Science and Technology;Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai 200025, China

Received date: 2019-07-02

  Online published: 2019-09-05

Supported by

Supported by the National Science and Technology Major Project of China(No. 2018ZX10102001-002-004), the Shanghai Natural Science Foundation (No. 19ZR1462600)and the National Natural Science Foundation of China(No. 81772225)

摘要

细粒棘球绦虫的幼虫寄生于中间宿主(人、牛、羊等)肝、肺等脏器后发展成包囊,压迫、刺激宿主脏器,引起细粒棘球蚴病,严重危害人体健康和畜牧业发展。全球患细粒棘球蚴病的人数超过100万,被世界卫生组织列为要求重点关注的热带病之一。随着分子生物学技术的发展,目前把细粒棘球绦虫分为9个基因型(G1、G3~G8、G10和狮株),每种基因型的地区分布、宿主种类、致病性等不尽相同。该综述主要对全球细粒棘球绦虫基因多态性的研究进展进行综述,并对发展方向进行展望,为进一步开展细粒棘球蚴病防治研究提供数据支撑。

本文引用格式

魏玉环 , 胡媛 , 曹建平 . 细粒棘球绦虫基因多态性的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2019 , 37(4) : 481 -485 . DOI: 10.12140/j.issn.1000-7423.2019.04.019

Abstract

The larvae of Echinococcus granulosus parasitize in the liver and lungs of the intermediate host (human, cattle, sheep, etc.) and develop into cysts that damage the organs and cause hydatidosis. The disease is still a seriously public health problem that threats the health of people and hurdles the animal husbandry in the endemic areas. It is estimated that more than 1 million people are suffering from hydatidosis, listed as one of serious tropical diseases by the World Health Organization. Based on the genetic variation E. granulosus has been classified into 9 genotypes (G1, G3-G8, G10 and E. felidis) that differ in the regional distribution, host species and pathogenicity. This review focuses on the research progress on the genetic polymorphism of E. granulosus and research direction, providing supporting data for better understanding and control of hydatidosis.

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