作者简介：王军（1988-）,博士研究生,助教,从事疟原虫感染与免疫相关研究。E-mail:
收稿日期: 2018-11-30
网络出版日期: 2019-09-05
基金资助
国家自然科学基金（No. 81572013,No. 81702019）
Recent progress in immune checkpoint molecules in Plasmodium infection and immunity
Received date: 2018-11-30
Online published: 2019-09-05
Supported by
Supported by the National Natural Science Foundation of China (No. 81572013, No. 81702019)
王军 , 沈燕 , 李悦 , 赵亚 . 免疫检查点分子调控在疟原虫感染与免疫中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2019 , 37(4) : 472 -480 . DOI: 10.12140/j.issn.1000-7423.2019.04.018
Malaria is still a life-threatening infectious disease transmitted by mosquito worldwide. It is necessary for host to maintain a delicate balance between pro-and anti-inflammatory immune responses to efficiently eliminate pathogens without inducing immunopathology. In recent years, breakthroughs in immune checkpoint molecules involved in anti-tumor and anti-autoimmune diseases have brought new enlightenment to the anti-malaria immunotherapy in chronic and severe infections. Studies have shown that blocking the immune checkpoint signaling in the chronic malaria infections could restore host immune response and accelerate the elimination of Plasmodium infection. In severe malaria caused by the acute infection of Plasmodium, moderately enhancing the signal of immune checkpoint molecules could reduce the immune response and alleviate the immunopathology caused by Plasmodium infection. This paper provides a brief review of the current progress in immune checkpoint molecules in Plasmodium infection and immunity.
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