目的 评价广东省华支睾吸虫病高流行区（中山市和江门市新会区）实施的综合防治措施，为其他地区提供可复制、可推广的综合防控经验。方法 2019—2023年中山市和江门市新会区实施华支睾吸虫病综合防治措施。采用线上线下结合的方式开展健康教育；结合新农村建设进行环境改造，普及卫生厕所和安全用水；对阳性感染者派发阿苯达唑进行药物治疗；通过培训和实操提升专业能力进行防治队伍建设。2个项目点在综合防治措施干预后，分别选取东、西、南、北、中5个方位各1个乡（镇、街道）的1个行政村（社区），整群抽取3周岁以上居民200人开展华支睾吸虫病人群感染调查，并以项目开始前的最近一次人群感染调查结果作为基线数据进行对比。在2019年防治项目开始前和2023年终期评估时，分别从调查人群中随机抽取150人进行人群健康行为问卷调查。结果 2019—2023年，中山市和新会区开展华支睾吸虫防治健康教育的行政村分别为277个和224个，覆盖率均达100%。2023年中山市和新会区的人群防治知识知晓率分别达96.0%（261/272）和98.0%（245/250），分别比2019年项目开展前的60.0%（150/250）和70.0%（105/150）升高了60.0%和40.0%。环境改造方面，中山市新建卫生厕所89 850所，新增安全卫生用水户数89 850户；新会区新建卫生厕所17 094所，新增安全卫生用水户数16 968户，两地卫生厕所和安全用水覆盖率均达100%。中山市和新会区通过社区人群感染调查和医疗机构的规范门诊分别发现华支睾吸虫阳性感染者10 424人和22 427人，派发药物10 185人和16 821人，驱虫覆盖率达97.71%和75.00%。专业人员培训率显著提升，中山市从91.67%（66/72）上升至100%（103/103），新会区从52.94%（90/170）上升至98.05%（201/205）。经过5年防治，中山市和新会区的华支睾吸虫感染率分别从基线调查的37.28%（400/1 073）和34.18%（499/1 460）下降至终期评估调查的11.52%（131/1 137）和10.20%（102/1 000），差异有统计学意义（χ² = 625.24、188.35，均P < 0.05）。结论 广东省中山市和江门市新会区通过实施包括健康教育、环境改造、药物治疗、防治队伍建设在内的综合防治措施，显著降低了人群华支睾吸虫感染率，提高了防治知识知晓率和环境卫生水平，可向其他地区进行推广。

Objective To investigate the effectiveness of the integrated clonorchiasis control programme in hyperendemic areas of Guangdong Province (Zhongshan City and Xinhui District of Jiangmen City), so as to provide reproducible and scalable integrated control experiences in other disease-affected regions. Methdos Integrated clonorchiasis control measures were implemented in Zhongshan City and Xinhui District of Jiangmen City during the period from 2019 to 2023, including online and offline health education, environmental improvements focusing on construction of sanitary toilets and provision of safe water in the text of new rural construction, albendazole given to Clonorchis sinensis-infected individuals, improvements of professional capabilities among disease control teams by means of training and hands-on practices. An administrative village (community) was selected from each township (street) in eastern, western, southern, northern and central parts according to geographical locations in two implementation areas after implementation of the integrated control measures. A total of 200 residents at ages of over 3 years were sampled using the cluster sampling method for detection of the prevalence of human clonorchiasis. And use the findings from the most recent population infection survey conducted prior to the project’s initiation as baseline data for comparison. In addition, a total of 150 individuals were randomly sampled from residents subjected to surveys of the prevalence of C. sinensis human infections in 2019 prior to the programme and 2023 at the final evaluation for questionnaire surveys of healthy human behaviors. Results There were 227 administrative villages received health education pertaining to clonorchiasis control knowledge in Zhongshan City, and 224 in Xinhui District, with a coverage rate of 100% in both areas from 2019 to 2023. The awareness of human clonorchiasis control knowledge was 96.0% (261/272) in Zhongshan City and 98.0% (245/250) in Xinhui District in 2023, which increased by 60.0% and 40.0% relative to 2019 before implementation of the programme [60.0% (150/250) and 70.0% (105/150)], respectively. In terms of environmental improvements, 89 850 new sanitary toilets were built and 89 850 households with access to safe water were provided in Zhongshan City, and 17 094 new sanitary toilets were built and 16 968 households with access to safe water were provided in Xinhui District, with 100% coverage rates of sanitary toilets and safe water supply in both areas. There were 10 424 and 22 427 C. sinensis-infected individuals identified through community-based surveys on human infections and standardized clonorchiasis clinics in medical institutions in Zhongshan City and Xinhui District, and 10 185 and 16 821 individuals given deworming chemicals, with deworming coverage rates of 97.71% and 75.00%, respectively. The proportion of professionals receiving training increased from 91.67% (66/72) to 100% (103/103) in Zhongshan City and from 52.94% (90/170) to 98.05% (201/205) in Xinhui District. The prevalence of C. sinensis infections reduced from 37.28% (400/1 073) at baseline to 11.52% (131/1 137) at the final evaluation in Zhongshan City (χ² = 625.24, P < 0.05) and from 34.18% (499/1 460) to 10.20% (102/1 000) in Xinhui District following implementation of 5-year integrated control programmes (χ² = 188.35, P < 0.05), respectively. Conclusion Through systematic interventions, Zhongshan City and Xinhui District in Guangdong Province significantly reduced the infection rate of C. sinensis, enhanced public awareness of prevention knowledge, and improved environmental sanitation, providing replicable and scalable experiences for comprehensive control in other regions.